Cytochrome P-450 CYP3A Inhibitors: all 906 studies that test it

Page 4 of 10. Open to participants first (60), then studies with results posted, then the rest; newest registration first within each.

• Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular ResponseCompletedNCT06262932Phase 4
• Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy SubjectsCompletedNCT06255951Phase 1
• Drug Interaction StudyCompletedNCT06194864Phase 1
• A Study to Assess the Effects of Itraconazole, Food, and pH on the Drug Levels of BMS-986368 in Healthy ParticipantsCompletedNCT06170723Phase 1
• Food Effects of GST-HG171 Tablets Combined With Ritonavir in Healthy Chinese ParticipantsActive, not recruitingNCT06084507Phase 1
• Drug Interaction Study Between Tegoprazan, Bismuth, Amoxicillin and ClarithromycinCompletedNCT05915871Phase 1
• Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis VersicolorCompletedNCT05862714Phase 1
• Electrophysiological Effects of Potential QT Prolonging DrugsCompletedNCT05716854Phase 1
• A Study of PBI-200 With Ritonavir or Cobicistat in Healthy VolunteersCompletedNCT05692570Phase 1
• A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer PatientsTerminatedNCT05679388Phase 1
• Study to Evaluate Itraconazole Administered as Inhaled Dry Powder in Adults With Asthma and ABPATerminatedNCT05667662Phase 2
• Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous LeukemiaStatus unknownNCT05638763Phase 2
• Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or ItraconazoleCompletedNCT05631678Phase 1
• HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPICompletedNCT05602597Phase 1
• Itraconazole in Advanced Ovarian CancerStatus unknownNCT05591560Not applicable
• Comparative Study Between Pulse Therapy With Oral Itraconazole Versus Continuous Oral Terbinafine Therapy for Treatment of OnychomycosisCompletedNCT05578950Phase 1
• Comparative Study Between Pulsed and Continuous Itraconazole for the Treatment of OnychomycosisCompletedNCT05567484Phase 1
• A Trial of Cobicistat and Gemcitabine and Nab-Paclitaxel in Patients with Advanced Stage or Metastatic Pancreatic Ductal AdenocarcinomaTerminatedNCT05494866Phase 1
• Refralon Versus Amiodarone for Cardioversion of Paroxysmal Fibrillation and Atrial FlutterCompletedNCT05445297Phase 4
• A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19TerminatedNCT05386472Phase 1
• A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Compared to the Co-administration of the Separate Available Formulations of Darunavir and Cobicistat Under Fed Conditions in Healthy ParticipantsCompletedNCT05378906Phase 1
• PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.CompletedNCT05255276Phase 1
• Susceptibility-Guided Therapy for Helicobacter Pylori Infection TreatmentWithdrawnNCT05250050Phase 4
• A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed ConditionsCompletedNCT05236738Phase 1
• Once Daily Dosing of Lonafarnib Co-administered With Ritonavir for Treatment of Chronic Hepatitis D Virus InfectionCompletedNCT05229991Phase 3
• 14-day PCAB-based High-dose Dual Therapy and14-day PCAB-based Triple Therapy vs 14-day PPI-based Reverse Hybrid TherapyStatus unknownNCT05191888Phase 4
• A Drug-Drug Interaction Study Between ATI-2173 and Midazolam or Clarithromycin in Healthy SubjectsCompletedNCT05137600Phase 1
• A Prospective Study on Optimizing Treatment for ABPAStatus unknownNCT05129033Not applicable
• Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter AblationStatus unknownNCT05125042Not applicable
• A Study to Evaluate Drug-Drug Interaction of Larotinib With Itraconazole and Rifampin in Healthy Adult ParticipantsCompletedNCT05057949Phase 1
• Bismuth-containing Quadruple Therapy for Helicobacter Pylori EradicationCompletedNCT05049902Phase 4
• Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's DiseaseTerminatedNCT05049525Phase 2
• Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic PatientsStatus unknownNCT05023577Phase 4
• A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult ParticipantsCompletedNCT04981704Phase 1
• A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of AdavosertibTerminatedNCT04959266Phase 1
• Study to Evaluate Effects of Food or Proton Pump Inhibitor on the Pharmacokinetics of Itraconazole in Healthy VolunteersCompletedNCT04942652Phase 1
• Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Randomized Clinical Trial of 10 and 14 DaysStatus unknownNCT04901117Phase 4
• Comparison of Efficacy of Double Dose Oral Terbinafine Vs Itraconazole in Treatment of Dermatophyte Infections of Skin.CompletedNCT04880980Phase 3
• Neuro-pharmacological Properties of Repurposed Ketoconazole in GlioblastomasTerminatedNCT04869449Early Phase 1
• Prophylactic Amiodarone for Shockable Cardiac ArrestStatus unknownNCT04845607Phase 3
• A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary AspergillosisCompletedNCT04824417Phase 3
• Study Evaluating the Efficacy and Safety of Miconazole Nitrate + Domiphen Bromide Vaginal Cream in the Treatment of Subjects With Acute Vulvovaginal CandidiasisStatus unknownNCT04813822Phase 2
• Comparison of Remdesivir Versus Lopinavir/ Ritonavir and Remdesivir Combination in COVID-19 PatientsStatus unknownNCT04738045Phase 4
• Anti-inflammatory Action of Oral Clarithromycin in Community-acquired PneumoniaCompletedNCT04724044Phase 3
• Comparison of Efficacy of Triple Regimen Based on Clarithromycin VS Metronidazole in ChildrenStatus unknownNCT04721704Not applicable
• A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Under Fed ConditionsCompletedNCT04718805Phase 1
• A Study to Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the BodyCompletedNCT04712396Phase 1
• Helicobacter Pylori Eradication in Functional DyspepsiaCompletedNCT04697641Not applicable
• A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat as Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared With Co-administration of the Separate AgentsCompletedNCT04661397Phase 1
• Effect of Long Term Clarithromycin for Prevention of Exacerbations in Non-cystic Fibrosis Bronchiectasis in Asian PopulationsStatus unknownNCT04658277Not applicable
• Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 InfectionCompletedNCT04622891Not applicable
• Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori InfectionCompletedNCT04621487Not applicable
• Comparing Different Regimens for Eradication of Helicobacter Pylori in KuwaitCompletedNCT04617613Phase 4
• Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation StudyTerminatedNCT04594746Phase 4
• Fruquintinib CYP3A Inhibitor and Inducer StudyCompletedNCT04557397Phase 1
• Evaluate Bioequivalence of Voriconazole(200mg/Vial) .CompletedNCT04552353Phase 4
• GLS4/RTV and TAF Drug-drug InteractionCompletedNCT04551261Phase 1
• Assessment and Management of Chronic Dyspepsia in Eastern UgandaCompletedNCT04525664Early Phase 1
• Australasian COVID-19 Trial (ASCOT) ADAptive Platform TrialActive, not recruitingNCT04483960Phase 3
• CCRT With Itraconazole in Locally Advanced Squamous Esophageal CancerStatus unknownNCT04481100Phase 2
• A Study of Combination Therapies to Treat COVID-19 InfectionWithdrawnNCT04459702Phase 2
• The Nitazoxanide Plus Atazanavir for COVID-19 StudyTerminatedNCT04459286Phase 2
• Pharmacokinetic Interactions of Quadruple Therapy With Anaprazole/Amoxicilin/Clarithromycin/BismuthStatus unknownNCT04444011Phase 1
• Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"Status unknownNCT04403100Phase 3
• Anti-inflammatory Clarithromycin for Improving COVID-19 Infection EarlyCompletedNCT04398004Phase 2
• Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial FibrillationStatus unknownNCT04392921Not applicable
• Rapid Reinitiation of a Single Tablet Antiretroviral Therapy Using Symtuza® in HIV-1 Infected Treatment-Experienced Patients Off Therapy. (ReSTART)CompletedNCT04388904Phase 4
• A Study to Assess the Effect of a Strong CYP3A Inhibitor, on Surufatinib in Healthy SubjectsCompletedNCT04372407Phase 1
• OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor OutcomeWithdrawnNCT04365582Phase 3
• Amiodarone or Verapamil in COVID-19 Hospitalized Patients With SymptomsCompletedNCT04351763Phase 2/3
• Efficacy and Safety of Ganovo (Danoprevir) Combined With Ritonavir in the Treatment of SARS-CoV-2 InfectionCompletedNCT04345276Phase 4
• Clinical Trial to Evaluate Pharmacological Interactions Between γ-hydroxybutyrate (GHB) and CobicistatCompletedNCT04322214Phase 1
• A Study to Examine the Acceptable Taste and to Estimate the Amount of Atazanavir and Cobicistat in the Body When Taken as a Combination Product Versus When Taken as Separate Products at the Same TimeCompletedNCT04263350Phase 1
• Evaluating and Comparing the Safety and Efficiency of ASC09/Ritonavir and Lopinavir/Ritonavir for Novel Coronavirus InfectionTerminatedNCT04261907Not applicable
• A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV PneumoniaStatus unknownNCT04261270Phase 3
• Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19Status unknownNCT04252274Phase 3
• Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Sofosbuvir in Treatment-naïve Patients With Chronic Hepatitis C Genotype 1CompletedNCT04246723Phase 2
• A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat When Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Co-administration of the Separate AgentsTerminatedNCT04236453Phase 1
• Prevention of Post-Operative Cardiac ArrhythmiasStatus unknownNCT04234906Phase 4
• Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac SurgeryStatus unknownNCT04223739Phase 4
• A Study of Darunavir in Combination With Cobicistat or Ritonavir, and Dabigatran Etexilate in Healthy ParticipantsCompletedNCT04208061Phase 1
• A Therapeutic Equivalence Study of Ketoconazole Cream 2%CompletedNCT04203342Phase 3
• Drug-drug Interaction (DDI) Study to Assess Effect of Itraconazole and Rifampicin Upon OlorofimCompletedNCT04171739Phase 1
• Evaluate the Safety, Tolerability, and Antiviral Activity of GLS4 With Ritonavir in Patients With Chronic HBV InfectionCompletedNCT04147208Phase 2
• The Epidemiology and Optimal Treatment of Helicobacter Pylori in MyanmarCompletedNCT04132479Phase 4
• Rapid Atrial Fibrillation Treatment StrategyStatus unknownNCT04092621Phase 4
• Three Induction Treatments on Cryptococcal MeningitisStatus unknownNCT04072640Early Phase 1
• RPV+DRV/Cobi Dual Therapy in Subjects With HIV Controlled InfectionStatus unknownNCT04064632Phase 4
• Prevention of New Onset AF After TAVI (PAF-TAVI Trial)CompletedNCT03991754Phase 3
• Use Of Oral Itraconazole In Patients With Locally Limited Basocellular Carcinoma Of Skin.Status unknownNCT03972748Not applicable
• A Study of Itraconazole in the Management of Superficial Fungal Infections in IndiaTerminatedNCT03923010Phase 4
• Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With CPACompletedNCT03920527Phase 3
• Prophylaxis Against Postoperative Atrial Fibrillation in Patients Undergoing On-pump CABGStatus unknownNCT03905759Phase 2/3
• Pharmacokinetic Boosting of OsimertinibCompletedNCT03858491Early Phase 1
• A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy VolunteersCompletedNCT03843060Phase 1
• A Pharmacokinetic Study of Narlaprevir as a Single Dose or With Ritonavir Combination in Patients With Hepatic Impairment and Healthy Matched VolunteersCompletedNCT03832426Phase 1
• Comparative Study of Human Immunodeficiency Virus Negative Host Talaromyces Between Voriconazole and Amphotericin Sequential Itraconazole TherapyStatus unknownNCT03827278Not applicable
• Immunomodulatory Effect of Macrolides in Naturally Occurring Influenza Virus Infections in the CommunitySuspendedNCT03824847Phase 4
• A Study to Assess the Drug-Drug Interaction Between Bedaquiline and Clarithromycin in Healthy Adult ParticipantsCompletedNCT03800550Phase 1
• Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain MetastasesTerminatedNCT03796273Early Phase 1

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