Cytochrome P-450 CYP3A Inhibitors: all 906 studies that test it

Page 6 of 10. Open to participants first (60), then studies with results posted, then the rest; newest registration first within each.

• Concentrations of Voriconazole in Blood and BAL-fluid After Inhalation and Oral AdministrationTerminatedNCT02396225Not applicable
• First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCLStatus unknownNCT02388581Phase 2
• A Study to Evaluate the Absolute Bioavailability of Intranasal and Oral Esketamine and the Effects of Clarithromycin on the Pharmacokinetics of Intranasal Esketamine in Healthy ParticipantsCompletedNCT02343289Phase 1
• AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial FibrillationTerminatedNCT02341105Phase 4
• A Study to Investigate the Safety, Tolerability and Pharmacokinetics of RO6889678 and the Combination of RO6889678 With Ritonavir in Healthy ParticipantsTerminatedNCT02321384Phase 1
• Taste Properties of Atazanavir and CobicistatCompletedNCT02307656Phase 1
• Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)Status unknownNCT02294955Not applicable
• A Single Dose Pharmacokinetic (PK) and Safety Study of GSK2838232 With and Without Ritonavir (RTV) Conducted in Healthy SubjectsTerminatedNCT02289482Phase 1
• Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of DeflazacortCompletedNCT02286635Phase 1
• Amphotericin-B and Voriconazole for Pulmonary BlastomycosisTerminatedNCT02283905Phase 4
• A Phase 1 Antiretroviral Drug-Drug Interaction Study in Healthy Volunteers (DDI)CompletedNCT02277600Phase 1
• Study to Investigate the Effect of Ketoconazole Mediated CYP3A4 Inhibition on Pharmacokinetics of Tamsulosin in Healthy Male VolunteersCompletedNCT02264171Phase 1
• Effect of Cytochrome P 450 3A4 Inhibition by Itraconazole on the Single Oral Dose Pharmacokinetics of CilobradineCompletedNCT02264041Phase 1
• Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic ImpairmentCompletedNCT02259855Phase 1
• Hormonal Mechanisms of Sleep RestrictionCompletedNCT02256865Early Phase 1
• Study of Pharmacokinetic Interaction Between Kaletra® (LPV/r) and BILR 355 BS Plus Ritonavir in Healthy SubjectsCompletedNCT02256826Phase 1
• Study of Pharmacokinetic Interaction Between Combivir® (ZDV+3TC) and BILR 355 BS Plus Ritonavir in Healthy SubjectsCompletedNCT02256774Phase 1
• Pharmacokinetics of Single Doses of BILR 355 BS Given With Ritonavir in Healthy Male VolunteersCompletedNCT02253953Phase 1
• Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of BILR 355 BS Plus Low Dose Ritonavir in HIV-uninfected Male VolunteersCompletedNCT02253914Phase 1
• Pharmacokinetic Interaction Between TRUVADA™ and BILR 355 BS Plus Ritonavir in Healthy VolunteersCompletedNCT02253901Phase 1
• Study to Determine the Effects of Multiple-dose Omeprazole on the Single-dose Pharmacokinetics of Tipranavir (TPV) Coadministered With Ritonavir (RTV) in Healthy Adult VolunteersCompletedNCT02253875Phase 1
• Pharmacokinetic of Tadalafil Co-administered With Tipranavir/Ritonavir to Healthy Male VolunteersCompletedNCT02253862Phase 1
• Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of RitonavirCompletedNCT02253836Phase 1
• Pharmacokinetics of Tipranavir/Ritonavir and Its Metabolites in Healthy Male SubjectsCompletedNCT02253797Phase 1
• Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of TipranavirCompletedNCT02251769Phase 1
• Bioavailability of Tipranavir/Ritonavir Paediatric Solution Compared to Tipranavir/Ritonavir Capsules in Healthy Female and Male SubjectsCompletedNCT02251158Phase 1
• The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy VolunteersCompletedNCT02251119Phase 1
• Clarithromycin Plus CTd Regimen for Patients With Newly Diagnosed Multiple MyelomaStatus unknownNCT02248428Phase 3
• Study of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Methadone Administered in Healthy VolunteersCompletedNCT02245451Phase 1
• Pharmacokinetics of Atorvastatin With Tipranavir/Ritonavir and the Effect of Antacid on the Pharmacokinetics of Single-Dose Tipranavir/Ritonavir in Healthy VolunteersCompletedNCT02245269Phase 1
• Bioequivalence of Two Different Oral Solutions Tipranavir Administered in Combination With Ritonavir to Healthy VolunteersCompletedNCT02244190Phase 1
• Voriconazole for IPA in Chinese Patients With COPDStatus unknownNCT02234739Phase 4
• Effect of Steady State TPV/r on Intracellular Concentrations of Zidovudine and Carbovir for Patients With HIVTerminatedNCT02229760Phase 1/2
• MT2013-37R: Voriconazole Monitoring in Pediatric Stem Cell Transplant PatientsCompletedNCT02227797Phase 1
• Effects of Steady-state Efavirenz 600 mg QD (Sustiva®) on Tipranavir Concentration at Steady-state in Healthy Adult VolunteersCompletedNCT02226991Phase 1
• Pharmacokinetic Interaction Study of Steady-state Tipranavir/Ritonavir (TPV/r) With Single-dose Valaciclovir (VAL) in Healthy VolunteersCompletedNCT02226978Phase 1
• SSAT061: PK of DTG and EVT/COBI in Healthy VolunteersCompletedNCT02219217Phase 1
• Comparison of Two Combinations in Antiretroviral Post-Exposure Prophylaxis for HIV-1: Tenofovir/Emtricitabine (Truvada ®) + Lopinavir/Ritonavir (Kaletra ®) vs Tenofovir/Emtricitabine/Cobicistat/Elvitegravir (Stribild ®). Prospective, Randomized, Open.CompletedNCT02198443Phase 4
• Effects of Single-dose and Steady-state TPV/RTV on the Steady-state Pharmacokinetics of Fluconazole in Healthy Adult VolunteersCompletedNCT02195466Phase 1
• Relative Bioavailability of Single Doses of Dabigatran Etexilate When Administered Alone or in Combination With a Single Dose of Ketoconazole or in Combination With q.d. Ketoconazole at Steady State in Healthy Male and Female VolunteersCompletedNCT02170675Phase 1
• Fenretinide Lym-X-Sorb + Ketoconazole + Vincristine for Recurrent or Resistant NeuroblastomaTerminatedNCT02163356Phase 1
• ITT-5 Mechanisms of Spermatogenesis in ManWithdrawnNCT02147964Phase 2
• Antiarrhythmic Drugs Assessment in Preventing Atrial FibrillationStatus unknownNCT02145546Phase 4
• Drug-drug Interaction (DDI) RifabutinCompletedNCT02138084Phase 1
• Effect Of Itraconazole On The Pharmacokinetics Of PalbociclibCompletedNCT02131298Phase 1
• Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy VolunteersWithdrawnNCT02130661Phase 1
• Topical Itraconazole in the Treatment of Basal Cell CarcinomaCompletedNCT02120677Early Phase 1
• Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal WomenCompletedNCT02100553Phase 1
• To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male VolunteersCompletedNCT02093728Phase 1
• A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of TMC647055 in Combination With Ritonavir (Part 1) and the Co-administration of TMC435, TMC647055 and Ritonavir (Part 2) in Healthy Japanese ParticipantsCompletedNCT02064842Phase 1
• DDI Study of BMS-663068 With Etravirine (ETR) and/or Darunavir (DVR) + Ritonavir (RTV)CompletedNCT02063360Phase 1
• A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or DonepezilCompletedNCT02055703Phase 1
• Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In Men With Castration-Resistant Prostate Cancer (CRPC)WithdrawnNCT02054793Phase 1/2
• Drug-Drug Interaction Study Between CJ-12420 and Clarithromycin in Healthy Male SubjectsCompletedNCT02052336Phase 1
• Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial HypertensionStatus unknownNCT02023450Early Phase 1
• Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIVActive, not recruitingNCT02016924Phase 2/3
• Atrial Fibrillation and By-pass SurgeryStatus unknownNCT01955759Early Phase 1
• Evaluation of Budesonide and How It Interacts With Antifungal Drugs in People With Gastrointestinal Graft-Versus-Host DiseaseTerminatedNCT01950507Phase 1
• LAAM-HAART PET ImagingCompletedNCT01935830Early Phase 1
• Concomitant Therapy of H. PyloriStatus unknownNCT01922765Phase 4
• The PK and PD Interaction Between YH4808, Amoxicillin and Clarithromycin in Healthy SubjectsCompletedNCT01921647Phase 1
• Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of NBI-98854 in Healthy SubjectsCompletedNCT01910480Phase 1
• Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to RaltegravirTerminatedNCT01902186Phase 4
• To Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of Olaparib, and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation to Patients With Advanced Solid TumoursCompletedNCT01900028Phase 1
• The Interaction of Two HIV Medications With Blood Clot Medications in Healthy VolunteersCompletedNCT01896622Phase 1
• A Study of Drug-drug Interaction Between Ritonavir and TMC435350 in Healthy VolunteersCompletedNCT01891851Phase 1
• Individualisation of Voriconazole Antifungal Therapy Antifungal TherapySuspendedNCT01887457Phase 2
• 15-day Sequential Therapy for Helicobacter Pylori Infection in KoreaCompletedNCT01887249Phase 4
• Pharmacokinetic Study of Clarithromycin in Very Low Birth Weight (VLBW)TerminatedNCT01851954Phase 2
• Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot StudyStatus unknownNCT01850277Phase 4
• Safety and Efficacy of Oral Versus Intravenous Amiodarone in the Treatment of AFStatus unknownNCT01817439Phase 3
• To Evaluate the Effect of Ritonavir or Omeprazole on the Pharmacokinetics of Samatasvir (IDX719) in Healthy Participants (MK-1894-006)CompletedNCT01813552Phase 1
• A Phase 4 Study to Evaluate Pharmacokinetics and Safety of Darunavir Along With Ritonavir in Healthy Male Japanese ParticipantsCompletedNCT01810887Phase 4
• A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of VismodegibCompletedNCT01772290Phase 1
• A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic MelanomaWithdrawnNCT01765556Phase 1
• Identification and Evaluation of Endogenous Markers for the Assessment of CYP3A ActivityCompletedNCT01760642Phase 1
• A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.CompletedNCT01736761Phase 4
• DDI Potential: Dapivirine Vaginal Ring and Miconazole NitrateCompletedNCT01731574Phase 1
• Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of DeathStatus unknownNCT01722942Not applicable
• Early Access to Low-dose Ritonavir (TMC114/r) and Other Antiretrovirals (ARVs) for Treatment-naive or Early Treatment Experienced in HIV-1 PatientsCompletedNCT01702090Phase 4
• Pharmacokinetic Study of Super-boosted Lopinavir/Ritonavir Given With RifampinTerminatedNCT01700790Phase 4
• Clinical Trial of Hydroquinone Versus Miconazol in MelasmaStatus unknownNCT01661556Phase 4
• WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8CompletedNCT01659437Phase 2/3
• A Study of Ritonavir-Boosted Invirase (Saquinavir) in Treatment-Naïve HIV-1 Infected PatientsCompletedNCT01638650Phase 1
• ANNAPURNA: A Study of The Combination of RO5466731, RO5190591, Ritonavir and Copegus (Ribavirin) With or Without RO5024048 in Patients With Chronic Hepatitis C Who Are Either Treatment-Naïve or Have Previously Experienced a Null Response to Interferon-Based TreatmentCompletedNCT01628094Phase 2
• Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary AspergillosisCompletedNCT01621321Phase 2/3
• A Study to Assess the Bioequivalence of Darunavir When Co-Administrated With Cobicistat Under Fed and Fasted ConditionsCompletedNCT01619527Phase 1
• Atazanavir/r + Lamivudine Dual TherapyCompletedNCT01599364Phase 4
• A Study of The Relative Bioavailability of Ritonavir-Boosted Danoprevir Fixed Dose Combination Tablets in Healthy VolunteersCompletedNCT01592318Phase 1
• A Study of Drug-Drug Interaction Between Danoprevir Coadministered With Low-Dose Ritonavir and Tenofovir Disoproxil Fumarate or AtazanavirCompletedNCT01592305Phase 1
• A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy VolunteersCompletedNCT01591850Phase 1
• A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Abiraterone Following Administration of Abiraterone Acetate Tablets in Healthy Adult MenCompletedNCT01588782Phase 1
• A Study of Potential Drug-Drug Interaction Between Efavirenz and Danoprevir With Low Dose Ritonavir in Healthy VolunteersCompletedNCT01588002Phase 1
• Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of OvaryTerminatedNCT01584297Phase 2
• The Mochudi Prevention Project ART ProtocolTerminatedNCT01583439Not applicable
• ATCF (Azole Therapy in Cystic Fibrosis)CompletedNCT01576315Phase 2
• Assessment of Target Site Pharmacokinetics of Voriconazole in Healthy Volunteers During Sequence TherapyCompletedNCT01539330Phase 4
• A Study of Drug-Drug Interaction Between Danoprevir/Low-Dose Ritonavir and Raltegravir in Healthy VolunteersCompletedNCT01531647Phase 1
• A Study of Drug-Drug Interaction Between Darunavir and Danoprevir Administered Together With Low-Dose Ritonavir in Healthy VolunteersCompletedNCT01519336Phase 1
• Salvage Therapy With High Dose Oral Clarithromycin in Relapsed or Refractory Extranodal Marginal Zone LymphomaCompletedNCT01516606Phase 2

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