Cyclooxygenase 2 Inhibitors: all 667 studies that test it

Page 1 of 7. Open to participants first (39), then studies with results posted, then the rest; newest registration first within each.

• Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric AdenotonsillectomyNot yet recruitingNCT07870447Phase 1/2
• Pre-Emptive Parecoxib Sodium for Pain Control During CT-Guided Lung Nodule LocalizationRecruitingNCT07675473Phase 4
• A Multicenter, Prospective, Randomized, Open-label Phase Ib/II Study of Celecoxib Plus Pembrolizumab and Gemcitabine/Cisplatin Versus Pembrolizumab and Gemcitabine/Cisplatin in Patients With CK5/6-High Unresectable Locally Advanced or Metastatic Intrahepatic CholangiocarcinomaNot yet recruitingNCT07632235Phase 1/2
• SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionNot yet recruitingNCT07597902Phase 2
• Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive CapsulitisRecruitingNCT07493226Not applicable
• Etoricoxib in Patients With Parkinsonian DiseaseRecruitingNCT07370532Phase 2
• Celecoxib in Parkinson Disease as Adjuvant TherapyRecruitingNCT07246278Phase 1/2
• Meloxicam in Mohs Micrographic SurgeryRecruitingNCT07200544Phase 4
• Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver CancerRecruitingNCT07174570Phase 2
• Efficacy of Methylprednisolone for Pain Control After ACL RepairRecruitingNCT07158476Phase 4
• TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin TherapyNot yet recruitingNCT07139405Phase 2
• Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection PainNot yet recruitingNCT07116304Not applicable
• Triple Negative Breast Cancer and Celecoxib. Pilot StudyRecruitingNCT07104266Phase 2
• QL1706 Plus Celecoxib in Advanced Esophageal Squamous Cell CarcinomaNot yet recruitingNCT07049185Phase 2
• Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States PopulationRecruitingNCT06997068Phase 2
• Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal CancerRecruitingNCT06903858Phase 2
• Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer ProgressionRecruitingNCT06839144Phase 2
• Celecoxib for Prevention of Progression in Peutz-Jeghers SyndromeRecruitingNCT06722534Not applicable
• Stony Brook Medicine Anti-Inflammatory TrialNot yet recruitingNCT06699966Phase 4
• Efficacy and Safety of Parecoxib vs. Indomethacin in Preventing Post-ERCP PancreatitisNot yet recruitingNCT06623513Phase 2
• Bioequivalence of Two Formulations of Parecoxib in Healthy Volunteers Under Fasting ConditionsNot yet recruitingNCT06600282Phase 4
• Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid HemorrhageRecruitingNCT06579274Phase 2
• Celecoxib for ENT Pain ManagementRecruitingNCT06505187Phase 2
• The Effect of Pregabalin and Etoricoxib on Pain Alone Versus in CombinationNot yet recruitingNCT06401499Phase 4
• Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic SurgeriesRecruitingNCT06379425Phase 4
• Bioequivalence Study of Generic Celecoxib 200 mg CapsulesNot yet recruitingNCT06337422Phase 1
• Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency DepartmentNot yet recruitingNCT06315920Phase 3
• Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee OsteoarthritisRecruitingNCT06245109Phase 4
• Efficacy, Safety and Tolerability Study of Meloxicam Injection in Subjects After Abdominal SurgeryNot yet recruitingNCT05950152Phase 2
• Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder ArthroscopyNot yet recruitingNCT05852093Early Phase 1
• The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple MyelomaRecruitingNCT05841550Phase 1/2
• Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal CancerRecruitingNCT05731726Phase 2
• Effects and Mechanisms of Celecoxib on Intracerebral HemorrhageRecruitingNCT05434065Phase 2
• A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)RecruitingNCT05429970Not applicable
• Colorectal Metastasis Prevention International Trial 2RecruitingNCT03919461Phase 2
• Perioperative Intervention to Reduce Metastatic Processes in Pancreatic Cancer Patients Undergoing Curative SurgeryRecruitingNCT03838029Phase 2
• Nonopioid Analgesia After Labral SurgeryRecruitingNCT03825809Phase 2/3
• Timed Aspirin Chronobiome StudyNot yet recruitingNCT03590821Early Phase 1
• CELECOXIB Plasma and Cerebral Spinal Fluid Pharmacokinetics in ChildrenRecruitingNCT01344200Phase 2
• Phase II Study of Ovulation in Obese WomenCompletedNCT06306131Phase 2Results posted
• Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven DaysCompletedNCT05695352Phase 2Results posted
• Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse EventsCompletedNCT05476679Phase 1/2Results posted
• Safety and Pharmacokinetics of N1539 in Children 2 to <17 Years of Age Following SurgeryTerminatedNCT05315479Phase 4Results posted
• Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)CompletedNCT05291598Phase 3Results posted
• Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee ArthroplastyCompletedNCT05188053Phase 4Results posted
• Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 PatientsTerminatedNCT05077969Phase 2Results posted
• PET Imaging of Cyclooxygenase in Multiple SclerosisTerminatedNCT05062083Phase 2Results posted
• PROUD Study - Preventing Opioid Use DisordersTerminatedNCT04766996Phase 4Results posted
• Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID TreatmentCompletedNCT04765644Phase 4Results posted
• Multimodal Pain Management After Robotic-Assisted Total Laparoscopic HysterectomyCompletedNCT04429022Phase 3Results posted
• Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck CancerTerminatedNCT04162873Phase 2Results posted
• Individualizing Anti-Inflammatory Medications for Adults With Axial Spondyloarthritis: A Series of N-of 1 TrialsTerminatedNCT04115098Phase 2Results posted
• Polarized Dendritic Cell (aDC1) Based Treatment, Interferon Alpha-2, Rintatolimod, and Celecoxib for the Treatment of HLA-A2+ Refractory MelanomaTerminatedNCT04093323Phase 2Results posted
• Chemokine Modulation Therapy and Standard Chemotherapy Before Surgery for the Treatment of Early Stage Triple Negative Breast CancerCompletedNCT04081389Phase 1Results posted
• A Multimodal Analgesia Protocol Adapted for Ambulatory SurgeryCompletedNCT04015908Phase 4Results posted
• Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal ConditionsTerminatedNCT03912428Phase 1Results posted
• Study of Post-Herniorrhaphy Non-opioid MMA RegimensCompletedNCT03907176Phase 3Results posted
• Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing UrethroplastyCompletedNCT03859024Phase 4Results posted
• Nonopioid Analgesia After Anterior Cruciate Ligament ReconstructionCompletedNCT03818932Phase 2/3Results posted
• Nonopioid Analgesia After Rotator Cuff RepairCompletedNCT03818919Phase 2Results posted
• NSAIDs vs. Coxibs in the Presence of AspirinTerminatedNCT03699293Phase 4Results posted
• A Study to Compare the Amount of Meloxicam in the Blood When it is Taken as Capsules or as TabletsCompletedNCT03684265Phase 1Results posted
• Photodynamic Therapy-Induced Immune Modulation: Part IIITerminatedNCT03643744Phase 1Results posted
• A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness ScaleCompletedNCT03570554Phase 2Results posted
• Efficacy, Tolerability, Safety, and Pharmacokinetic Study of DFN-15CompletedNCT03554772Phase 2Results posted
• Opioid-Free Shoulder ArthroplastyCompletedNCT03540030Phase 4Results posted
• Non-Steroidal Anti-inflammatory Drugs in Axial SpondyloarthritisTerminatedNCT03473665Phase 4Results posted
• MAST Trial: Multi-modal Analgesic Strategies in TraumaCompletedNCT03472469Phase 4Results posted
• Evaluation of Preoperative N1539 in Total Knee ArthroplastyCompletedNCT03434275Phase 3Results posted
• Celecoxib, Recombinant Interferon Alfa-2b, and Rintatolimod in Treating Patients With Colorectal Cancer Metastatic to the LiverCompletedNCT03403634Phase 2Results posted
• Toradol v. Celecoxib for Postoperative PainCompletedNCT03331315Phase 2Results posted
• Evaluation of Preoperative N1539 in Colorectal SurgeryCompletedNCT03323385Phase 3Results posted
• Bunionectomy Study for Postoperative Analgesia (EPOCH 1)CompletedNCT03295721Phase 3Results posted
• Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)CompletedNCT03237481Phase 3Results posted
• Total Knee Arthroplasty Infiltration Study for Postoperative AnalgesiaCompletedNCT03015532Phase 2Results posted
• Phase 2B Upper Extremity Nerve Block StudyCompletedNCT03011333Phase 2Results posted
• Celecoxib After TonsillectomyCompletedNCT02934191Phase 2Results posted
• Celecoxib for Thyroid Eye DiseaseTerminatedNCT02845336Phase 2Results posted
• Evaluation of Perioperative Celecoxib for Hip ArthroscopyCompletedNCT02779166Not applicableResults posted
• MUA to Treat Postoperative Stiffness After Total Knee ArthroplastyCompletedNCT02739035Phase 4Results posted
• Evaluation of N1539 Following Major SurgeryCompletedNCT02720692Phase 3Results posted
• Evaluation of N1539 Following Abdominoplasty SurgeryCompletedNCT02678286Phase 3Results posted
• Evaluation of N1539 Following Bunionectomy SurgeryCompletedNCT02675907Phase 3Results posted
• Eight Week Study of Treatment With DFD-07 for Actinic Keratosis of the Face and ScalpCompletedNCT02654717Phase 2Results posted
• Placebo-Controlled Evaluation of N1539 Following Bunionectomy SurgeryCompletedNCT02540265Phase 2Results posted
• Pilot Herniorrhaphy Study for Postoperative AnalgesiaCompletedNCT02504580Phase 2Results posted
• Variability in Response to Non-steroidal Anti-inflammatory DrugsTerminatedNCT02502006Phase 1Results posted
• COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSCCompletedNCT02484664Phase 2Results posted
• HTX-011 for Post-bunionectomy AnalgesiaCompletedNCT02471898Phase 2Results posted
• European Celecoxib Trial in Primary Breast CancerCompletedNCT02429427Phase 3Results posted
• Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part BCompletedNCT02413203Not applicableResults posted
• Stress and Inflammation in Late-Life DepressionCompletedNCT02389465Phase 4Results posted
• Antigen-specific Cancer Immunotherapy (TG01) and Gemcitabine as Adjuvant Therapy in Resected Pancreatic CancerCompletedNCT02261714Phase 1/2Results posted
• Study to Evaluate the Effect of Celecoxib on the Efficacy and Safety of Amlodipine in Subjects With Hypertension Requiring Antihypertensive TherapyCompletedNCT02172040Phase 3Results posted
• Effectiveness and Safety of Different Doses of BI 1026706 in Patients With Postoperative Dental PainCompletedNCT02084511Phase 1Results posted
• A Phase II Trial Using Meloxicam Plus Filgrastim in Patients With Multiple Myeloma and Non-Hodgkin's LymphomaCompletedNCT02078102Phase 2Results posted
• Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or MediastinumTerminatedNCT02054104Phase 1/2Results posted
• Effectiveness of Two Different Doses of BI 1026706 on the Overall Peak-to-Peak (PtP) N2/P2-component Amplitude of Laser (Somatosensory, Radiant-heat) Evoked Potentials (LEP) in UVB(Ultraviolet)-Irradiated Skin in Healthy Male VolunteersCompletedNCT02037165Phase 1Results posted
• Meloxicam vs Placebo for MobilizationCompletedNCT02003625Phase 2Results posted
• The Single Dose Pharmacokinetics of Two and Proof of Efficacy of One New Etoricoxib Gel Formulation in Participants With Osteoarthritis (MK-0663-168)CompletedNCT01980940Phase 1/2Results posted

← Cyclooxygenase 2 Inhibitors overview