Drug
Chlorambucil clinical trials
- studies test it
- 22
- open now
- 0
- in phase 3
- 10
- first study started
- 1993
How studies write it
Studies that test it under each name
Development codes
Studies by the year they started
22 studies that test it; most in 2013 (3)
| Year | Studies |
|---|---|
| 1993 | 1 |
| 1995 | 1 |
| 1999 | 1 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 1 |
| 2004 | 1 |
| 2005 | 1 |
| 2006 | 1 |
| 2007 | 1 |
| 2008 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 3 |
| 2014 | 3 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 10
- Phase 3
- 10
- Phase 4
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 10 · Other 12
Hoffmann-La Roche (4) · International Extranodal Lymphoma Study Group (IELSG) (2) · GlaxoSmithKline (2) · Pharmacyclics LLC. (1) · TG Therapeutics, Inc. (1) · Genentech, Inc. (1) · French Study Group on Chronic Lymphoid Leukemia (1) · Leukemia Research Fund (1)
Often tested with
Tested in the same studies.
Rituximab (4) · Fludarabine (3) · Obinutuzumab (2) · Fludarabine phosphate (2) · Venetoclax (1) · Ibrutinib (1) · Umbralisib (1) · Ofatumumab (1)
Studies
Open first, then newest update. How each study uses Chlorambucil is read from its arms, and is right about nine times in ten.
Testing it · 22
- Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT LymphomaActive, not recruitingPhase 2International Extranodal Lymphoma Study Group (IELSG)NCT01808599Written as Chlorambucil
- Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic LeukemiaCompletedPhase 3Hoffmann-La RocheNCT02242942Written as Chlorambucil
- Dose Escalation Study of Gleevec and Chlorambucil in Previously Treated Chronic Lymphocytic Leukemia PatientsTerminatedPhase 1/2Jewish General HospitalNCT00558961Written as Gleevec and Chlorambucil
- A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)CompletedPhase 3Pharmacyclics LLC.NCT02264574Written as Chlorambucil
- TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)CompletedPhase 1TG Therapeutics, Inc.NCT02100852Written as TGR-1202 + Obinutuzumab + Chlorambucil
- Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT LymphomaCompletedPhase 3International Extranodal Lymphoma Study Group (IELSG)NCT00210353Written as chlorambucil (drug)
- Chlorambucil + Lenalidomide and Lenalidomide Maintenance in Untreated Elderly With Chronic Lymphocytic Leukemia (CLL)TerminatedPhase 1/2Gruppo Italiano Malattie EMatologiche dell'AdultoNCT01403246Written as Lenalidomide; Chlorambucil
- A Study of MabThera (Rituximab) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia.CompletedPhase 2Hoffmann-La RocheNCT00738374Written as chlorambucil
- An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic LeukemiaCompletedPhase 2Genentech, Inc.NCT01868893Written as Chlorambucil
- A Study of MabThera (Rituximab) Plus Chlorambucil in Participants With Chronic Lymphocytic Leukemia.CompletedPhase 2Hoffmann-La RocheNCT00532129Written as Chlorambucil
- Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström MacroglobulinemiaCompletedPhase 3French Study Group on Chronic Lymphoid LeukemiaNCT00566332Written as Chlorambucil
- A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic LeukemiaCompletedPhase 2GlaxoSmithKlineNCT01563055Written as chlorambucil, tablets
- A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe)CompletedPhase 4Hoffmann-La RocheNCT01056510Written as chlorambucil
- A Phase II, Open Label, Single Arm, Multicenter Study of Chlorambucil in Japanese Previously Untreated Patients With Chronic Lymphocytic LeukemiaCompletedPhase 2GlaxoSmithKlineNCT01808326Written as chlorambucil, tablets
- Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic LeukemiaCompletedPhase 3Leukemia Research FundNCT00004218Written as chlorambucil
- Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the StomachStatus unknownPhase 3Lymphoma Trials OfficeNCT00003617Written as chlorambucil
- Chlorambucil Compared With Radiation Therapy in Treating Patients With Previously Untreated Stage III or Stage IV Follicular LymphomaStatus unknownPhase 3Commissie Voor Klinisch Toegepast OnderzoekNCT00028691Written as chlorambucil
- Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's LymphomaStatus unknownPhase 3Scotland and Newcastle Lymphoma GroupNCT00003639Written as chlorambucil
- Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic LymphomaCompletedPhase 3Taunton and Somerset HospitalNCT00608374Written as chlorambucil
- Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL)TerminatedPhase 2CephalonNCT00151736Written as Chlorambucil
See all 22 studies that test Chlorambucil →
Given in every arm · 7 — Chlorambucil is usual care beside what is tested
- A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and ComorbiditiesTerminatedPhase 1Hoffmann-La RocheNCT02336048Written as Chlorambucil
- Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic LeukemiaCompletedPhase 1Gilead SciencesNCT01088048Written as Chlorambucil
- A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic LeukemiaCompletedPhase 3Hoffmann-La RocheNCT01905943Written as Chlorambucil
- Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic LeukemiaTerminatedPhase 3Novartis PharmaceuticalsNCT00748189Written as chlorambucil, tablets
- CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)CompletedPhase 3Hoffmann-La RocheNCT01998880Written as chlorambucil
- CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2)CompletedPhase 3Hoffmann-La RocheNCT02053610Written as chlorambucil
- CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a)CompletedPhase 3Hoffmann-La RocheNCT01010061Written as chlorambucil
As the comparator · 15 — what is tested is compared with Chlorambucil
- A Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL.RecruitingPhase 3Ascentage Pharma Group Inc.NCT06319456Written as Chlorambucil
- ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLLRecruitingPhase 3Beijing InnoCare Pharma Tech Co., Ltd.NCT04578613Written as Chlorambucil
- A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Active, not recruitingPhase 3Janssen Research & Development, LLCNCT03462719Written as Chlorambucil
- Study of Acalabrutinib Versus Chlorambucil Plus Rituximab in Adult Subjects With Previously Untreated Chronic Lymphocytic LeukemiaActive, not recruitingPhase 3AstraZenecaNCT04075292Written as Chlorambucil
- Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLLActive, not recruitingPhase 3Acerta Pharma BVNCT02475681Written as Chlorambucil
- A Study of BGB-16673 Compared to Investigator's Choice in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Covalent Bruton Tyrosine Kinase (BTK) InhibitorsActive, not recruitingPhase 3BeOne MedicinesNCT06970743Written as Chlorambucil
- Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic LeukemiaTerminatedPhase 3TG Therapeutics, Inc.NCT02612311Written as Chlorambucil
- Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)CompletedPhase 3CelgeneNCT00910910Written as Chlorambucil
- Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic LeukemiaCompletedPhase 3German CLL Study GroupNCT00262795Written as Chlorambucil
- A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic StatusTerminatedPhase 4Hoffmann-La RocheNCT01283386Written as Chlorambucil
- Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic LeukemiaTerminatedPhase 3Gilead SciencesNCT01980875Written as Chlorambucil
- Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLLCompletedPhase 3Pharmacyclics LLC.NCT01722487Written as Chlorambucil
- Bendamustine Hydrochloride Injection for Initial Treatment of Chronic Lymphocytic LeukemiaCompletedPhase 2Jiangsu Simcere Pharmaceutical Co., Ltd.NCT01109264Written as Chlorambucil
- A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive TreatmentStatus unknownPhase 3University of LiverpoolNCT01678430Written as Chlorambucil
- Bendamustine Hydrochloride Injection for Previously Untreated Chronic Lymphocytic LeukemiaStatus unknownPhase 3Shandong Lanjin Pharmaceuticals Co.,LtdNCT01657955Written as Chlorambucil
Codes
What other systems call Chlorambucil · ClinicalTrials.gg INT007190
- MeSH (NLM) D002699ChlorambucilConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 18D0SL7309CHLORAMBUCILConfirmed FDA, NLM, Wikidata
- RxNorm 2346Confirmed FDA, Wikidata
- Wikidata Q415939chlorambucilConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C362ChlorambucilOne source FDA
- DrugBank DB00291One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002699 | Chlorambucil | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 18D0SL7309 | CHLORAMBUCIL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2346 | — | Confirmed FDA, Wikidata |
| Wikidata | Q415939 | chlorambucil | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C362 | Chlorambucil | One source FDA |
| DrugBank | DB00291 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.