Antimetabolites: all 7,305 studies that test it

Page 31 of 74. Open to participants first (1,098), then studies with results posted, then the rest; newest registration first within each.

• ALLOPURINOL AND LISINOPRIL FOR DIABETIC KIDNEY PROTECTION: A COMPARATIVE STUDY IN NORMOURICEMIC TYPE 2 DIABETICSCompletedNCT07177898Not applicable
• Pilot Study of Reduced Venetoclax ExposureActive, not recruitingNCT07163793Phase 2
• UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune DiseasesActive, not recruitingNCT07155369Not applicable
• Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract CancerSuspendedNCT07146646Phase 2
• Capecitabine as Maintenance Therapy vs Observation in Early-stage Triple-negative Breast CancerCompletedNCT07143097Phase 2
• Maintenance Therapy With Selinexor and Azacitidine in TP53 Mutant AML/MDS After TransplantationActive, not recruitingNCT07094464Phase 1
• Efficacy of Oral Tofacitinib in Combination of Narrow Band UVB in Treatment of VitiligoActive, not recruitingNCT07044141Phase 1
• Allopurinol and Pathogenesis of CirrhosisCompletedNCT07033533Phase 1/2
• Comparing 177Lu-Dotatate/Capecitabine Combination Treatment With 177Lu-Dotatate in Neuroendocrine Tumor PatientsTerminatedNCT07012330Phase 2
• Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular CarcinomaSuspendedNCT06968195Phase 1
• Impact of Selenium on Methotrexate Induced Spermatotoxicity; A Comparative StudyCompletedNCT06951282Phase 1/2
• Evaluating the Effectiveness of Decitabine With Gemcitabine, Oxaliplatin for Relapsed/Refractory Peripheral T-cell LymphomaTerminatedNCT06941688Phase 2
• A Single-arm, Multicenter Exploratory Clinical Trial of Anlotinib Combined With TQB2450 and the SOX Regimen as First-line Treatment for Advanced Gastric Cancer With Low PD-L1 ExpressionActive, not recruitingNCT06939452Phase 2
• Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction AdenocarcinomaActive, not recruitingNCT06914687Phase 2
• A Study of Azacitidine and Venetoclax Versus a Stem Cell Transplant in People 65 Years and Older With Acute Myeloid LeukemiaWithdrawnNCT06903702Phase 2
• FCN-338 in Combination With Azacitidine or Chemotherapy in Myeloid NeoplasmsActive, not recruitingNCT06858618Phase 2
• Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal MetastasisActive, not recruitingNCT06809530Phase 1/2
• To Compare the Efficacy of Weekly Azathioprine Pulse Versus Betamethasone Oral Mini-Pulse in the Treatment of Moderate to Severe Alopecia AreataCompletedNCT06786689Phase 2
• DPD Guided 5-FU Precision Treatment in Gastro-intestinal Cancer PatientsCompletedNCT06782022Phase 2
• Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal MetastasisActive, not recruitingNCT06762080Phase 1/2
• Intraoperative 5-fluorouracil Augmentation of TrabeculectomyCompletedNCT06745856Phase 3
• Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCATerminatedNCT06739252Phase 2
• Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepatic Biliary Tract CancerActive, not recruitingNCT06717464Phase 2
• Carac & PDT Combination in the Treatment Of Actinic KeratosesCompletedNCT06712381Phase 1/2
• UF-KURE-BCMA CAR-T Cells in Patients With Relapsed or Refractory Multiple MyelomaWithdrawnNCT06698744Phase 1
• Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)SuspendedNCT06694454Phase 1/2
• A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal MalignanciesWithdrawnNCT06690281Phase 2
• A Study of BEBT-209 in Combination With Chemotherapy for the Treatment of Advanced Triple-Negative Breast CancerCompletedNCT06685796Phase 2
• Bemarituzumab in FGFR2b+ Patients With Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction, Who Failed at Least One Prior Line of Palliative ChemotherapyActive, not recruitingNCT06680622Phase 2
• Venetoclax + Azacitidine in Patients With Acute Myeloid LeukemiaActive, not recruitingNCT06668558Phase 2
• ALLG AMLM26 INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal Evolution as Pre-emptive Therapy in AML): A Multi-arm, Precision-based, Recursive, Platform TrialActive, not recruitingNCT06664879Phase 1/2
• AK112 and Cadonilimab Combined With Chemotherapy for 1L Treatment of Metastatic Pancreatic CancerActive, not recruitingNCT06646055Phase 1/2
• A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at HomeSuspendedNCT06639958Not applicable
• Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)Active, not recruitingNCT06632951Phase 2
• Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung CancerActive, not recruitingNCT06632327Phase 3
• STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and MelanomaWithdrawnNCT06626256Phase 1
• A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell LymphomaActive, not recruitingNCT06624085Phase 1
• A Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT06624059Phase 3
• 5-Azacytidine With Steroids for Gastrointestinal GVHD (5-AZA FOR GVHD)WithdrawnNCT06598332Early Phase 1
• AK112 Combined With Chemotherapy Versus Durvalumab Combined With Chemotherapy in Advanced Biliary Tract CancerActive, not recruitingNCT06591520Phase 3
• Local Methotrexate Injections for the Treatment of Nail PsoriasisTerminatedNCT06578728Phase 4
• Efficacy and Safety of Serplulimab Combined With Chemotherapy as Neoadjuvant Treatment for Locally Advanced Gastric Cancer or Adenocarcinoma of Esophagogastric JunctionActive, not recruitingNCT06576921Phase 2
• Extension Study, Pilot, Compassionate Use of Azacitidine 300 mg Film Coated Tablets for Acute Myeloid Leukaemia (AML) PatientsActive, not recruitingNCT06572982Not applicable
• Multi-antigen Specific CD8+ T Cells With Decitabine and Lymphodepleting Chemotherapy for the Treatment of Patients With Relapsed or Refractory AML or MDS Following an Allogeneic Hematopoietic Cell Transplantation From a Matched DonorWithdrawnNCT06572631Phase 1
• A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast CancerTerminatedNCT06568692Phase 2
• Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell CarcinomasActive, not recruitingNCT06557889Phase 2
• Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie IntakeCompletedNCT06556277Not applicable
• ALPP CAR-T Cells for ALPP-Positive Advanced Solid TumorsCompletedNCT06556108Phase 1/2
• Safety and Efficacy of Anti-CD20/CD30 CAR-T Cells in Subjects with Relapsed/Refractory LymphomaStatus unknownNCT06532643Early Phase 1
• A PhaseⅠStudy of ONO-7475 in Combination With ONO-4538 and Gemcitabine Plus Nab-paclitaxel (GnP), the Standard of Care, and ONO-7475 in Combination With GnP in Patients With Pancreatic CancerActive, not recruitingNCT06532331Phase 1
• First-line Gemcitabine Plus Cisplatin in Locally Advanced (IIIC Stage) Breast Cancer PatientsActive, not recruitingNCT06531447Phase 2
• Testing the Combination of an Anti-Cancer Drug, Iadademstat, With Other Anti-Cancer Drugs (Venetoclax and Azacitidine) for Treating AMLSuspendedNCT06514261Phase 1
• A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell LymphomaActive, not recruitingNCT06508658Phase 3
• Obinutuzumab, Zanubrutinib, and Lenalidomide Followed Short-Cycle of Obinutuzumab and Cytarabine in Newly Diagnosed Mantle Cell LymphomaActive, not recruitingNCT06504199Phase 2
• Comparison of the Effectiveness of Single-Dose Methotrexate Protocol With Letrozole + Single-Dose Methotrexate in the Medical Treatment of Patients Diagnosed With Ectopic PregnancyCompletedNCT06504082Not applicable
• Study of 5-fluorouracil (5-FU) in Patients With Metastatic Colorectal CancerWithdrawnNCT06501989Phase 2
• A Trial of Gemcitabine, Pembrolizumab and IMM-101 as First Line Treatment in Patients With Metastatic Pancreatic CancerWithdrawnNCT06498518Phase 2
• Lonsurf® (Trifluridine/Tipiracil) Plus Chemotherapy in Metastatic Colorectal Cancer Prospective Study in TaiwanCompletedNCT06495463Not applicable
• Chiauranib in Patients With Locally Advanced or Metastatic Pancreatic Ductal AdenocarcinomaActive, not recruitingNCT06492915Phase 2
• Long Term Beta Thalassemia Treatment: Findings From The Extension PeriodActive, not recruitingNCT06490601Phase 2
• A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute LeukemiasWithdrawnNCT06474663Phase 1
• Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS MalignanciesWithdrawnNCT06466798Phase 1
• Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic CancerCompletedNCT06464965Phase 1
• Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid TumorsActive, not recruitingNCT06462222Phase 1/2
• Utidelone Capsule Plus Capecitabine (CAP) for Metastatic Breast CancerActive, not recruitingNCT06458413Phase 2
• A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive ChemotherapyActive, not recruitingNCT06456463Phase 2
• Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid LeukemiaSuspendedNCT06454409Phase 1
• Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic LeukemiaSuspendedNCT06447987Phase 1
• Nivolumab Plus Gemcitabine in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma-HN17-11CompletedNCT06440187Phase 2
• Fruquintinib Plus S-1 and Raltitrexed (RSF) for MCRCStatus unknownNCT06427005Phase 2
• A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerActive, not recruitingNCT06417814Phase 3
• Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal CancerActive, not recruitingNCT06417476Phase 2
• Irinotecan, TAS-102 Plus Bevacizumab as a Third-Line or Beyond Therapy in mCRC PatientsActive, not recruitingNCT06403709Phase 2
• Onvansertib in Combination With Gemcitabine and Nab-paclitaxel for the Treatment of Patients With Locally-advanced, Unresectable, or Metastatic Pancreatic Ductal AdenocarcinomaWithdrawnNCT06398587Phase 2
• EF-39 PANOVA-4: Study of Tumor Treating Fields Concomitant With Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-LineTreatment for Metastatic Pancreatic Ductal AdenocarcinomaCompletedNCT06390059Phase 2
• A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced or Metastatic Triple-Negative Breast Cancer(PANKU-Breast02)Active, not recruitingNCT06382142Phase 3
• A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy AdultsTerminatedNCT06375772Phase 2
• Optimizing Ocular Outcomes: A Dual-armed Study for Periorbital Burn ManagementWithdrawnNCT06362226Phase 1
• DEC-C and Thioguanine for R/R AMLWithdrawnNCT06351306Phase 2
• A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01)Active, not recruitingNCT06343948Phase 3
• Holmium-166 TARE in Liver Limited Unresectable Colorectal Cancer PatientsTerminatedNCT06332079Phase 2
• Bioequivalence of Azacitidine 300 mg Film-Coated Tablets in Adult Patients With Acute Myeloid Leukaemia (AML)CompletedNCT06326697Phase 1
• First-line Regimen With QL1706 Plus Chemo ± Bev in PDAC PatientsActive, not recruitingNCT06313970Phase 2
• A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or DeletionsActive, not recruitingNCT06308419Phase 1
• Efficacy of Combination of Hdroxyurea and Thalidomide Over Hydroxyurea or Thalidomide in the Treatment of Transfusion Dependent Thalassemia in ChildrenCompletedNCT06299670Phase 4
• A Clinical Study of AL2846 Capsule Combined With Gemzar Injection in the Treatment of Advanced Pancreatic CancerCompletedNCT06278493Phase 1/2
• Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal CancerActive, not recruitingNCT06269978Phase 1
• Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung CancerActive, not recruitingNCT06268210Phase 2
• Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic CancerActive, not recruitingNCT06253520Phase 1
• A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.Active, not recruitingNCT06247995Phase 1/2
• Study of SHR-8068 Combined With Adebrelimab and Platinum-containing Chemotherapy in the Treatment of Advanced Gastric and Esophageal CancerActive, not recruitingNCT06247956Phase 2
• The Therapeutic Effect of Different Doses of CapecitabineCompletedNCT06246461Not applicable
• Comparison Of Efficacy And Safety Of Thalidomide Vs Hydroxyurea In Thalassemia Patients: A Single-Centre Pilot Study.CompletedNCT06239389Phase 2
• Cladribine Venetoclax in Monocytic AMLActive, not recruitingNCT06232655Phase 2
• Phase 2 Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Levoleucovorin in Japanese Participants Not Previously Treated for Metastatic Adenocarcinoma of the PancreasCompletedNCT06225999Phase 2
• A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)Active, not recruitingNCT06211764Phase 3
• Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal CancerActive, not recruitingNCT06210971Phase 2
• Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)WithdrawnNCT06210750Phase 2
• 5-fluorouracil for Treatment of Stable VitiligoCompletedNCT06209138Not applicable
• Injection of SHR-A1811 Versus Physician Choiced Treatment in Patients With Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-fu, and IrinotecanActive, not recruitingNCT06199973Phase 3

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