Antimetabolites: all 7,305 studies that test it
Page 32 of 74. Open to participants first (1,098), then studies with results posted, then the rest; newest registration first within each.
- Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance for Adult Acute Myeloid Leukemia (AML) PatientsWithdrawnNCT06180863Phase 2
- Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic DacryocystitisCompletedNCT06175676Phase 1
- Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLCTerminatedNCT06173505Phase 1/2
- Realizing Effectiveness Across Continents With HydroxyureaActive, not recruitingNCT06171217Phase 2
- Venetoclax in Combination With Azacitidine (VEN/AZA) Followed by Donor Lymphocyte Infusion (DLI) for Patients With Very High-Risk Acute Myeloid Leukemia (AML) Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)TerminatedNCT06158100Phase 1
- Mitoxantrone Hydrochloride Liposome Combined With Capecitabine in Patients With HER-2 Negative Advanced Breast CancerStatus unknownNCT06156761Not applicable
- Thalidomide and Hydroxyurea Combination in β-Thalassemia PatientsCompletedNCT06153784Phase 2/3
- Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic MelanomaCompletedNCT06151847Phase 2
- Neoadjuvant Tislelizumab With Chemotherapy for the Treatment of MSS Colon CancerActive, not recruitingNCT06124378Phase 2
- A Study Comparing BL-B01D1 With Physician's Choice of Chemotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma(PANKU-NPC01)Active, not recruitingNCT06118333Phase 3
- CAPEcitabine eXtension of Adjuvant Therapy for Pancreatic Adenocarcinoma: (CAPE-X)WithdrawnNCT06110598Phase 2
- Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and BevacizumabActive, not recruitingNCT06107413Phase 2
- Metyrapone for Mild Autonomous Cortisol Secretion (MACS)Active, not recruitingNCT06106295Phase 2
- Autologous T Cells Lentivirally Transduced to Express L1CAM-Specific Chimeric Antigen Receptors in Treating Patients With Locally Advanced and Unresectable or Metastatic Small Cell Neuroendocrine Prostate CancerWithdrawnNCT06094842Phase 1
- NEO-adjuvant Chemo-immunotherapy in Pancreatic CancerActive, not recruitingNCT06094140Phase 2
- Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met ProteinWithdrawnNCT06093503Phase 3
- PK/Efficacy Bridging Study of ASTX727 in Chinese Subjects With Myelodysplastic SyndromesActive, not recruitingNCT06091267Phase 1/2
- Phase I/II Study of SY-1425 (Tamibarotene) in Combination With Azacitidine and Venetoclax for Patients With Chronic Myelomonocytic LeukemiaWithdrawnNCT06085638Phase 1/2
- The Seven Trial: Exploiting the Unfolded Protein ResponseTerminatedNCT06076837Phase 1
- To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCLActive, not recruitingNCT06072131Phase 3
- Venetoclax Plus CACAG Regimen for Newly Diagnosed Acute Myeloid LeukemiaCompletedNCT06068621Phase 2
- Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before SurgerySuspendedNCT06050252Phase 2
- Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)Active, not recruitingNCT06048133Phase 2
- Methotrexate Infusion and Intrasilicone Injection During Diabetic VitrectomyCompletedNCT06038968Early Phase 1
- Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast CancerActive, not recruitingNCT06027268Phase 2
- A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to Compare the Pharmacokinetics of Oral Cladribine With the Reference Listed Drug, Intravenous CladribineTerminatedNCT06021600Phase 1
- Neoadjuvant Tremelimumab and Durvalumab With Gem/Cis in Intrahepatic CholangiocarcinomaWithdrawnNCT06017297Phase 2
- Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for HypophosphatasiaWithdrawnNCT06015750Phase 4
- Methotrexate for Immune Related Arthritis or Arthralgias (IMPACT 2.1)TerminatedNCT06001125Phase 2
- Clinical Efficacy of Trastuzumab in Combination With Capecitabine and Oxaliplatin for the Treatment of HER2-positive Advanced Gastric Cancer.CompletedNCT05997524Phase 2
- Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserineCompletedNCT05994703Phase 2
- Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal CancerActive, not recruitingNCT05990543Phase 1/2
- A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic CancerActive, not recruitingNCT05984602Phase 1
- Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and ChemoradiationActive, not recruitingNCT05975307Phase 2
- CART-BCMA/CS1 in Treating Patients With Relapsed or Refractory Multiple MyelomaWithdrawnNCT05950113Phase 1
- Mitoxantrone Hydrochloride Liposome Combined With Chemotherapy in Untreated de Novo Acute Myeloid LeukemiaCompletedNCT05941585Not applicable
- Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic CancerActive, not recruitingNCT05922930Phase 1/2
- The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)CompletedNCT05919992Early Phase 1
- Assessment of the Efficacy of Letrozole in the Treatment of Ectopic PregnancyStatus unknownNCT05918718Phase 1/2
- Efficacy and Safety of Surufatinib Combined With Gemcitabine and Albumin-bound Paclitaxel in the Peri-operative Treatment of Pancreatic CancerCompletedNCT05908747Phase 2
- Cladribine Plus Homoharringtonine and Cytarabine Regimen (CHA) for de Novo Acute Myeloid LeukemiaCompletedNCT05906914Phase 2
- REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity MitigationActive, not recruitingNCT05902533Phase 2/3
- Effects of Oral Cladribine on Remyelination and Inflammation in Multiple Sclerosis PatientsActive, not recruitingNCT05902429Phase 4
- Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum DisorderCompletedNCT05896605Phase 4
- Allopurinol Improves Heart Function in African Americans With Resistant HypertensionCompletedNCT05888233Phase 2
- A Study Comparing Treatment Preference Between Oral Decitabine/Cedazuridine and Azacitidine in Myelodysplastic Syndrome, Low-Blast Acute Myeloid Leukemia, or Chronic Myelomonocytic LeukemiaActive, not recruitingNCT05883956Phase 3
- GEM+Nab-Paclitaxel Plus Losartan Followed by Stereotactic Radiotherapy for Locally Advanced Pancreatic CancerWithdrawnNCT05861336Phase 2
- Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM PredictorsTerminatedNCT05853458Phase 4
- Second Line ERIbulin Followed by CApecitabine or the Reverse Sequence in HER2-negative Metastatic Breast Cancer PatientsStatus unknownNCT05833919Phase 2
- Allopurinol and Quality of Life in Liver CirrhosisCompletedNCT05828836Phase 2/3
- Magrolimab in Combination with Azacitidine After Allogeneic HCTin Treating Patients with High-Risk AML or MDSWithdrawnNCT05823480Phase 1
- To Study the Oral Bioavailability of a New Combination Formation of Decitabine and Tetrahydrouridine in Healthy MalesCompletedNCT05816356Phase 1
- A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid MalignanciesActive, not recruitingNCT05796570Phase 2
- Lazertinib+Pemetrexed/Carboplatin in Patients With EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to Prior LazertinibCompletedNCT05786430Phase 2
- Oral Azacitidine Combined With Venetoclax in Previously Untreated Higher-risk Myelodysplastic SyndromesActive, not recruitingNCT05782127Phase 1/2
- Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance Treatment for KRAS/BRAF Wild-type Metastatic Colorectal CancerCompletedNCT05775900Phase 1/2
- Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary CancerActive, not recruitingNCT05775159Phase 2
- CAR- PRISM (PRecision Intervention Smoldering Myeloma)Active, not recruitingNCT05767359Phase 2
- Trial of Cladribine and Low-Dose Cytarabine (LoDAC) Alternating With Decitabine vs. Hypomethylating Agents (HMA) Plus Venetoclax as Frontline Therapy for AML or High-Grade MDS in Patients Unfit for Intensive InductionWithdrawnNCT05766514Phase 2
- Oral Vinorelbine and Capecitabine in Advanced HER2-negative Breast CancerStatus unknownNCT05747326Phase 2
- HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological MalignanciesWithdrawnNCT05740449Phase 1/2
- Magrolimab in Combination With Cytotoxic Chemotherapy in Advanced Urothelial CarcinomaWithdrawnNCT05738161Phase 1
- D-Cycloserine+iTBS PK StudyCompletedNCT05731323Phase 1
- Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and NeckActive, not recruitingNCT05721755Phase 3
- Perioperative Chemotherapy Plus Trastuzumab Plus Toripalimab in HER2 Positive Locally Advanced Gastric or Esophagogastric Junction AdenocarcinomaActive, not recruitingNCT05715931Phase 2
- Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With ImmunotherapyTerminatedNCT05715229Phase 2
- A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)Active, not recruitingNCT05714202Phase 3
- Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical SurgeryActive, not recruitingNCT05713838Phase 2
- A Phase 3 Clinical Study to Evaluate Lemzoparlimab for Injection in Combination With Azacitidine (AZA) Versus AZA Monotherapy in Treatment-naïve Patients With Higher-risk Myelodysplastic Syndrome (MDS)TerminatedNCT05709093Phase 3
- CD19-Car T Cell Therapy for the Treatment of Older Adults With Acute Lymphoblastic Leukemia in First RemissionActive, not recruitingNCT05707273Phase 1
- Galunisertib Combined With Capecitabine in Advanced CRC With PMActive, not recruitingNCT05700656Phase 1/2
- Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant RecipientsActive, not recruitingNCT05699603Phase 2
- CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic CancerSuspendedNCT05685602Phase 1
- Hydroxyurea Treatment for Adult Sickle Cell Anemia Patients in KinshasaCompletedNCT05681598Not applicable
- Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic SyndromeCompletedNCT05673057Phase 1
- Gemcitabine and Docetaxel Therapy in High-risk BCG-naive Patients With Non-muscle Invasive Bladder CancerActive, not recruitingNCT05671900Not applicable
- Alternative Dosing And Prevention of Transfusions (ADAPT)Active, not recruitingNCT05662098Early Phase 1
- Switch-Maintenance Gemcitabine After First-Line Chemotherapy In Patients With Malignant Pleural MesotheliomaCompletedNCT05660616Phase 2
- Intravesical Gem/Doce in Patients With NMIBCActive, not recruitingNCT05644041Phase 2
- Low Dose Decitabine in Combination With Tirelizumab Comparison of Tirelizumab in the First-line Treatment of Advanced Esophageal Squamous Cell CarcinomaStatus unknownNCT05638984Phase 2
- Concurrent Chemoradiotherapy Combined With Immunotherapy in Patients With Potentially Resectable Pancreatic CancerStatus unknownNCT05634564Phase 2
- Study of Novel Treatment Combinations in Patients With Lung CancerActive, not recruitingNCT05633667Phase 2
- Methotrexate as Remission Maintenance Therapy After Remission-Induction With Tocilizumab and Glucocorticoids in Giant Cell ArteritisActive, not recruitingNCT05623592Phase 2
- ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung CancersTerminatedNCT05616624Phase 1/2
- A Study Investigating Interactions Between BMS-986322 and Rosuvastatin, Metformin and Methotrexate in Healthy ParticipantsCompletedNCT05615012Phase 1
- Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C MutationActive, not recruitingNCT05609578Phase 2
- Leflunomide Treatment for MEN1 Patients - the LUMEN1 TrialTerminatedNCT05605587Not applicable
- Efficacy and Safety of SOX Regimen Combined With Camrelizumab as Neoadjuvant Treatment in Locally Advanced Gastric Cancer: a Phase II, Single-arm StudyActive, not recruitingNCT05602935Phase 2
- Effect of Allopurinol on Markers of Mineral and Bone MetabolismCompletedNCT05601271Not applicable
- A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)TerminatedNCT05600426Phase 3
- D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT)Active, not recruitingNCT05591677Phase 2
- Cladribine Combined With G-CSF and Cytarabine as a Salvage Treatment in R/R ALLStatus unknownNCT05578378Phase 2/3
- Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple MyelomaActive, not recruitingNCT05577000Phase 1
- A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin and Febuxostat on the Pharmacokinetics of Methotrexate in Healthy SubjectsCompletedNCT05575297Phase 1
- A Study Evaluating Maintenance Therapy After First Line Chemotherapy in Metastatic Cancer PancreasStatus unknownNCT05566743Phase 2
- Indirect Pulp Capping Versus Pulpotomy With MTA for Treatment of Primary Molars With Deep CariesStatus unknownNCT05554952Not applicable
- Orelabrutinib,Rituximab and Methotrexate in Newly-diagnosed Primary Central Nervous System Lymphoma(PCNSL)Status unknownNCT05549284Phase 2
- Allopurinol to Prevent Cirrhosis Related MorbiditiesCompletedNCT05545670Phase 2/3
- Intravesical BCG vs GEMDOCE in NMIBCActive, not recruitingNCT05538663Phase 3
- MAD Study of IA-14069CompletedNCT05533372Phase 1