Alvimopan clinical trials
Also written Entereg.
How each study uses alvimopan is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 20 May 2008 · ENTEREG · NDA 021775 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
23 studies that test it; most in 2005 (3)
| Year | Studies |
|---|---|
| 2001 | 2 |
| 2002 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 3 |
| 2006 | 1 |
| 2009 | 1 |
| 2010 | 2 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 2 |
| 2016 | 1 |
| 2017 | 1 |
| 2018 | 2 |
| 2020 | 1 |
| 2024 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 11 · Other 12
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (11) · Scott Steele (1) · University of Virginia (1) · Washington University School of Medicine (1) · Jamie N. Bakkum-Gamez (1) · Hartford Hospital (1) · Intermountain Health Care, Inc. (1) · Memorial Sloan Kettering Cancer Center (1)
Studies
Open first, then newest update. How each study uses alvimopan is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 23
- A Study of Surgical Techniques During CystectomyRecruitingPhase 3Memorial Sloan Kettering Cancer CenterNCT06703476Written as Alvimopan
- Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery ProtocolRecruitingPhase 3Brigham and Women's HospitalNCT03216525Written as Alvimopan
- Alvimopan as a Rescue Treatment of Postoperative IleusCompletedPhase 4Scott SteeleNCT04405037Written as Alvimopan
- Alvimopan as Rescue in Post op IleusTerminatedPhase 3Sharon SteinNCT02742181Written as Alvimopan
- Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPECTerminatedPhase 2University of California, San DiegoNCT03352414Written as Alvimopan
- Trial of Alvimopan in Major Spine SurgeryCompletedPhase 4University of VirginiaNCT02789111Written as Alvimopan
- Alvimopan Use in Polytraumatized PatientsTerminatedPhase 4University of Puerto RicoNCT03068975Written as Alvimopan
- Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia RepairTerminatedNot applicableMedical College of WisconsinNCT02379858Written as Alvimopan
- Alvimopan and Ileus in PSFCompletedNot applicableWashington University School of MedicineNCT02218190Written as Alvimopan
- Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer PainCompletedPhase 3Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00241722Written as Alvimopan
- Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain MedicationCompletedPhase 2Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00101998Written as alvimopan
- Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative IleusCompletedPhase 3Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00388258Written as Alvimopan
- Accelerating Gastrointestinal RecoveryCompletedPhase 3Jamie N. Bakkum-GamezNCT01704651Written as Alvimopan
- Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative IleusCompletedPhase 3Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00205842Written as alvimopan
- A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical CystectomyCompletedPhase 4Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00708201Written as Alvimopan
- Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer PainCompletedPhase 3Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00259922Written as Alvimopan
- Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer PainCompletedPhase 3Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00256932Written as alvimopan
- Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain SubjectsCompletedPhase 2Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00135577Written as alvimopan
- Clinical Evaluation Of Alvimopan (SB767905) On Constipation And Related Symptoms Associated With OpioidTerminatedPhase 2Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT00331045Written as alvimopan
- Entereg Laparoscopic Colon Resection StudyCompletedPhase 2Hartford HospitalNCT01258569Written as Entereg
See all 23 studies that test alvimopan →
Given beside what is tested · 1 — alvimopan is usual care or a partner of the new treatment
Codes
What other systems call alvimopan · ClinicalTrials.gg INT004300
- MeSH (NLM) C419502alvimopanConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 677C126AETALVIMOPANConfirmed FDA, NLM, Wikidata
- RxNorm 480639One source FDA
- Wikidata Q72437563Alvimopan dihydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C49096AlvimopanOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C419502 | alvimopan | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 677C126AET | ALVIMOPAN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 480639 | — | One source FDA |
| Wikidata | Q72437563 | Alvimopan dihydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C49096 | Alvimopan | One source FDA |
Also registered as alvimopan anhydrous (UNII Q153V49P3Z · RxNorm 1516803).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.