Weight Gain clinical trials
The registry lists 317 studies for Weight Gain across more than 10 countries. 48 are recruiting or about to start. 123 of them are mainly about Weight Gain (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Gestational Weight Gain too: 439 studies, 71 open.
Get an email when these change. Save the Weight Gain studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (9) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (6) · Stanford University (6) · University of Michigan (6) · Corcept Therapeutics (5) · University of North Carolina, Chapel Hill (5) · Washington University School of Medicine (5) · University of Pennsylvania (5)
What is being tested here
Drugs under test in Weight Gain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here GLP-1 receptor agonists 6 open · Integrase inhibitors 1 open · Antipsychotics 8
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Oct 2027A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2) · Phase 3 · Eli Lilly and Company
- Nov 2026A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction · University College Cork
- Dec 2026Development of a Pregnancy Weight Management Service Model · Mackay Medical College
- Dec 2026Metreleptin in Anorexia Nervosa · Gabriella Milos
- Dec 2026Fluid Intake After Hemodialysis · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Feb 2027The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Feb 2027Intensive Longitudinal Assessment of Stress and Stress-related Concepts Across a Behavioral Weight Loss Intervention · University of Kansas Medical Center
- Mar 2027Grocery Delivery and Healthy Weight Gain Among Low-income Pregnant Young Women · University of Michigan
- May 2027Focused Echocardiography for Primary Care Physicians · University Hospital, Caen
- May 2027A Study of Niacin Regulation · Mayo Clinic
Who these studies take
Of the 32 Weight Gain studies recruiting now, 9 (28%) set no upper age limit and 23 (72%) stop at 75 or younger. 7 (22%) take children under 18. 8 (25%) are for women only and 2 (6%) for men only; 14 (44%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (6%) | 2 (6%) |
| 18 | 24 (75%) | 20 (63%) |
| 30 | 25 (78%) | 21 (66%) |
| 40 | 26 (81%) | 21 (66%) |
| 50 | 23 (72%) | 17 (53%) |
| 65 | 20 (63%) | 15 (47%) |
| 75 | 9 (28%) | 6 (19%) |
| 85 | 9 (28%) | 6 (19%) |
Across all 317 studies, recruiting or not: 68% stop at 75 or younger and 59% at 65; 27% take children; 24% are for women only and 4% for men only; 45% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Weight Gain studies take
Of 101 interventional studies with no phase under Weight Gain, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 27 mo12–47 · 101 studies | — | 30 mo12–47 · 95 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered1
- Changes in Body Composition Following Pharmacological Treatment for Obesity.Nov 2, 2026NCT07908940
Studies
Recruiting first, then most recently updated. Showing 50 of 317. Browse all 317 → or search them.
- Time Restricted Eating for WeIght LoSs MainTenance-2RecruitingNCT07190170Not applicable1 country
- Changes in Body Composition Following Pharmacological Treatment for Obesity.Enrolling by invitationNCT079089401 country
- Tapered Versus Abrupt Discontinuation of Semaglutide After Treatment of Recurrent Weight Gain or Suboptimal Response Following Metabolic and Bariatric SurgeryNot yet recruitingNCT07859176Phase 41 country
- Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight GainNot yet recruitingNCT07859163Phase 41 country
- Semaglutide 2.4 mg Once Weekly for Recurrent Weight Gain After Metabolic and Bariatric Surgery (RESURGE)Not yet recruitingNCT07859150Phase 41 country
- Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized StudyRecruitingNCT05652478Phase 21 country
- Nutritional Responses to Acute Exercise Performed on the LipoxMax in Obese AdolescentsNot yet recruitingNCT07844330Not applicable1 country
- Comparing Reduction With ESD- Versus APC-TOReRecruitingNCT06131281Not applicable1 country
- A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)RecruitingNCT06439277Phase 312 countries
- Development of a Pregnancy Weight Management Service ModelRecruitingNCT07814885Not applicable1 country
- The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy ExpenditureRecruitingNCT05545306Not applicable1 country
- Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL)RecruitingNCT07634653Not applicable1 country
- Nurse Led Intervention on Self Care Adherence and Quality of LifeRecruitingNCT07506980Not applicable1 country
- Metreleptin in Anorexia NervosaRecruitingNCT06305182Phase 21 country
- Exercise Effects on Adipose Tissue Structure and FunctionRecruitingNCT04812314Not applicable1 country
- No Guts No Glory ProbioticsRecruitingNCT07606014Phase 2/31 country
- Fluid Intake After HemodialysisRecruitingNCT047216521 country
- "Effects of High-Calorie Diets VS High-Calorie Formulas on Weight Gain in Children With Congenital Heart Disease "Not yet recruitingNCT07552688Not applicable1 country
- DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric BypassRecruitingNCT04894838Not applicable1 country
- A Study of Niacin RegulationRecruitingNCT06175403Early Phase 11 country
- Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm InfantsNot yet recruitingNCT07460089Not applicable1 country
- Weight Changes After Incretin-mimeticsNot yet recruitingNCT06795360Not applicable
- Focused Echocardiography for Primary Care PhysiciansNot yet recruitingNCT07427303Not applicable
- The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast CancerRecruitingNCT05780814Not applicable1 country
- Incretin Microdosing for Cardiometabolic Health in People With HIVRecruitingNCT07325500Phase 21 country
- Grocery Delivery and Healthy Weight Gain Among Low-income Pregnant Young WomenRecruitingNCT05000645Not applicable1 country
- Metabolic Changes Associated With Weight Gain After Treatment of AchalasiaNot yet recruitingNCT073346391 country
- Endoscopic Metabolic and Bariatric TherapiesEnrolling by invitationNCT057259671 country
- Exercise, Brain Activity, and Weight MaintenanceRecruitingNCT06511310Not applicable1 country
- Effect of Kangaroo Care on Test WeighingRecruitingNCT04252547Not applicable1 country
- : EFFECT OF PROBIOTIC SUPPLEMENTATION ON ATYPICAL ANTIPSYCHOTIC INDUCED WEIGHT GAIN IN PATIENTS ATTENDING PSYCHIATRIC CLINICS AT AINSHAMS UNIVERSITY HOSPITALS (A RANDOMIZED CONTROLLED TRIAL)RecruitingNCT06936137Phase 31 country
- BUMP2.0 Feasibility StudyNot yet recruitingNCT06882837Not applicable1 country
- A Novel Obesity Prevention Program for High-Risk Infants in Primary CareRecruitingNCT06028113Phase 21 country
- Weight Changes Among Martinican PrisonersRecruitingNCT059821321 country
- HealthyPregnancy - Digital Support for Pregnant Women with a BMI At 25 or Above (BMI≥25)RecruitingNCT06734910Not applicable1 country
- A Probiotic Strategy for Antipsychotic-induced Metabolic DysfunctionRecruitingNCT06729671Not applicable1 country
- Effect of Strength-resistance Exercise in the Reduction of Gestational Diabetes in Pregnant Women with Overweight or ObesityRecruitingNCT05840497Not applicable1 country
- Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized TrialRecruitingNCT06288854Not applicable1 country
- Evaluating the Effects of Adjunctive Aripiprazole on Weight and Metabolic Outcomes in FemalesNot yet recruitingNCT06590298Phase 4
- HIV-HEART Aging StudyRecruitingNCT043302871 country
- Food Replacement on Weight Control in Overweight VolunteersNot yet recruitingNCT06488339Not applicable
- Sleep and MetabolismRecruitingNCT05775627Not applicable1 country
- Semaglutide 2.4mg for Low Responders After Bariatric SurgeryNot yet recruitingNCT06287307Phase 4
- Bioenergetic Effects of Aging and Menopause (BEAM)RecruitingNCT04043520Phase 41 country
- Weight Change and the Risk of Chronic Pain Following Hip and Knee ArthroplastiesNot yet recruitingNCT06024161
- Haemodialysis fMRI Salt Appetite StudyRecruitingNCT040112541 country
- Growth of Preterm Infants Fed a Infant Milk Formula Containing High Versus Low Amounts of Beta-palmitateRecruitingNCT04541095Not applicable1 country
- The Breast Cancer Personalized Nutrition StudyRecruitingNCT04079270Not applicable1 country
- Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima IndiansCompletedNCT003401321 country
- Effect of RDX-002 on Postprandial Triglycerides in Subjects Treated With OlanzapineCompletedNCT05857566Phase 11 country