von Willebrand Diseases clinical trials
The registry lists 96 studies for von Willebrand Diseases across more than 10 countries. 25 are recruiting or about to start. 81 of them are mainly about von Willebrand Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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· Enrollment: 300 → 450 participants
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Who runs them
Takeda (8) · CSL Behring (7) · Baxalta now part of Shire (5) · Octapharma (5) · Nantes University Hospital (4) · University Hospital, Lille (4) · Assiut University (3) · Bio Products Laboratory (3)
What is being tested here
Drugs under test in von Willebrand Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Nov 2027A Study of Recombinant Von Willebrand Factor (rVWF) in Chinese Participants With Von Willebrand Disease (vWD) · Phase 3 · Takeda
- Dec 2026A Study of Bleeding and Treatment in Participants With Von Willebrand Disease · Hemab ApS
- Dec 2026Von Willebrand Factor in Pregnancy (VIP) Study · University of Washington
- Dec 2026Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West · University Hospital, Brest
- Dec 2026Endothelial Colony-Forming Cells in Patients With VWD, AVWS and Healthy Subjects · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Mar 2027External Multicenter Validation of the APTTO Model for Prolonged APTT Using Clot Waveform Analysis · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
- Jun 2027HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB · Alnylam Pharmaceuticals
- Jul 2027A Study Assessing HMB-002 in Participants With Von Willebrand Disease · Hemab ApS
Who these studies take
Of the 23 von Willebrand Diseases studies recruiting now, 15 (65%) set no upper age limit and 8 (35%) stop at 75 or younger. 14 (61%) take children under 18. 4 (17%) are for women only and 0 (0%) for men only; 3 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (35%) | 7 (30%) |
| 18 | 21 (91%) | 17 (74%) |
| 30 | 20 (87%) | 17 (74%) |
| 40 | 20 (87%) | 17 (74%) |
| 50 | 19 (83%) | 17 (74%) |
| 65 | 18 (78%) | 16 (70%) |
| 75 | 16 (70%) | 14 (61%) |
| 85 | 15 (65%) | 13 (57%) |
Across all 96 studies, recruiting or not: 31% stop at 75 or younger and 24% at 65; 57% take children; 11% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long von Willebrand Diseases studies take
Of 24 observational studies under von Willebrand Diseases, half reached primary completion within 71 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 71 mo45–97 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 96. Browse all 96 → or search them.
- HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMBRecruitingNCT07575308Phase 26 countries
- Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders StudyRecruitingNCT059164691 country
- A Pilot Crossover Trial of Prophylactic Wilate Compared to Placebo for Heavy Menstrual Bleeding in Patients With VWDRecruitingNCT06205095Phase 31 country
- Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)RecruitingNCT07115004Phase 310 countries
- External Multicenter Validation of the APTTO Model for Prolonged APTT Using Clot Waveform AnalysisRecruitingNCT074180991 country
- A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)RecruitingNCT05582993Phase 36 countries
- ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic DisordersRecruitingNCT043986281 country
- A Study Assessing HMB-002 in Participants With Von Willebrand DiseaseRecruitingNCT06754852Phase 1/23 countries
- A Phase II Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of SR604 Injection in Patients With Von Willebrand DiseaseRecruitingNCT07640893Phase 21 country
- Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic DiseasesRecruitingNCT04119908Not applicable1 country
- Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand DiseaseRecruitingNCT06651255Not applicable1 country
- The Severe Von Willebrand Disease (sVWD) Patient RegistryRecruitingNCT054375361 country
- A Study of Bleeding and Treatment in Participants With Von Willebrand DiseaseRecruitingNCT066102013 countries
- ATHNdataset RegistryRecruitingNCT068205151 country
- Development of a Device for Evaluating Primary Hemostasis Under Whole Blood Flow ConditionsRecruitingNCT037731591 country
- An Observational Study of Vonicog Alfa (rVWF) in Pediatric Participants With Von Willebrand Disease (vWD)RecruitingNCT074046441 country
- Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut GovernorateNot yet recruitingNCT074101301 country
- Endothelial Colony-Forming Cells in Patients With VWD, AVWS and Healthy SubjectsRecruitingNCT073580131 country
- A Study of Recombinant Von Willebrand Factor (rVWF) in Chinese Participants With Von Willebrand Disease (vWD)RecruitingNCT07129343Phase 31 country
- Von Willebrand Factor in Pregnancy (VIP) StudyRecruitingNCT041463761 country
- Efficacy and Safety of BT200 (Rondaptivon Pegol) in Patients With Type 2B Von Willebrand DiseaseRecruitingNCT07273721Phase 21 country
- Post Trial Access Program of TAK-577 for Von Willebrand Disease (VWD)AvailableNCT06173024
- Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)RecruitingNCT05776069Phase 1/28 countries
- Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French WestRecruitingNCT057736381 country
- World Bleeding Disorders RegistryRecruitingNCT033277791 country
- Efficacy of Alphanate FVIII/VWF Concentrate in Type 3 Von Willebrand PatientsTerminatedNCT00555555Phase 4
- Impact of Von Willebrand Factor and Its Multimers on AngiogenesisCompletedNCT048107021 country
- Effectiveness and Tolerability of Eqwilate in Real-life ConditionsActive, not recruitingNCT041069081 country
- ATHN 9: Severe VWD Natural History StudyCompletedNCT038534861 country
- Genetic Background of Patients With Low Von Willebrand Factor LevelsCompletedNCT05116501Not applicable1 country
- Efficacy and Safety of Fanhdi®, a High-purity Von Willebrand Containing FVIII Concentrate, in Pediatric Patients With Von Willebrand DiseaseWithdrawnNCT02472665Phase 41 country
- Prognostic Value of Implementing VCE on Top in Constitutional VWD-patients With GI-bleedingCompletedNCT04466878
- A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD)CompletedNCT02932618Phase 313 countries
- The Bleeding Assessment Tool (BAT)Active, not recruitingNCT075600071 country
- A Study on the Outcomes of Recombinant Von Willebrand Factor on Demand Treatment and Prevention and Treatment of Bleeding During and After Surgery in Adults With Inherited Von Willebrand Disease in the United Kingdom (UK)CompletedNCT064337781 country
- Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease (VWD) Patients <6 Years of AgeCompletedNCT04953884Phase 37 countries
- Frequency of Hemorrhages Associated With the Functional Anomalies of Willebrand Factor in Emergency PatientsCompletedNCT030709121 country
- Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN TrialCompletedNCT04344860Phase 31 country
- To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)CompletedNCT04770935Phase 12 countries
- The Lived Experience of People With Von Willebrand DiseaseCompletedNCT060646431 country
- A Study of Recombinant Von Willebrand Factor (rVWF) in Pediatric and Adult Participants With Severe Von Willebrand Disease (VWD)CompletedNCT03879135Phase 39 countries
- T-TAS® wS Method ComparisonCompletedNCT067102621 country
- Real-life Data of Constitutional Von Willebrand Disease in Western FranceCompletedNCT048873241 country
- Molecular and Clinical Profile of Von Willebrand Disease in SpainCompletedNCT028690741 country
- Type 3 Von Willebrand International Registries Inhibitor Prospective StudyCompletedNCT0246045810 countries
- Minimize Menorrhagia in Women With Von Willebrand DiseaseTerminatedNCT02606045Phase 31 country
- Registry of Patients With Von WilLEbrand Disease Treated With Voncento®CompletedNCT046578871 country
- A Survey to Describe the Experience and Unmet Needs of Persons Living With Von Willebrand Disease (VWD) and Their CaregiversCompletedNCT056955601 country
- Bleeding Incidence in VWD Patients Undergoing On-Demand TreatmentCompletedNCT040536998 countries
- Clinical Study to Investigate the Efficacy and Safety of Wilate During Prophylaxis in Previously Treated Patients With VWDCompletedNCT04052698Phase 38 countries