Tooth, Nonvital clinical trials
The registry lists 111 studies for Tooth, Nonvital across more than 10 countries. 18 are recruiting or about to start. 89 of them are mainly about Tooth, Nonvital (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Who runs them
Cairo University (29) · Federal University of Pelotas (5) · Istanbul Medipol University Hospital (4) · Ain Shams University (3) · Hacettepe University (2) · University of Nove de Julho (2) · Universitat Internacional de Catalunya (2) · University of Sao Paulo (2)
What is being tested here
Drugs under test in Tooth, Nonvital studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Saline Solution | 0 | 0 | 1 |
| Sodium Chloride | 0 | 0 | 1 |
| Allyl sulfide | 0 | 0 | 1 |
| Turmeric extract | 0 | 0 | 1 |
| Curcuma longa | 0 | 0 | 1 |
| Piroxicam | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Clinical Success of Onlays Fabricated With Different Types of Resin · Mersin University
- Jan 2027Clinical Comparison of Lithium Disilicate and 3D-Printed Resin Endocrowns · Medipol University
- Feb 2027Clinical Evaluation of Two Post Systems for Single Crown Restoration of Anterior Teeth · Cairo University
- Apr 2027Predictable Method for Restoring Endodontically Treated Teeth, Comparing Indirect and Direct Methods and Materials in Aesthetic Dentistry. · Riga Stradins University
- Jun 2027Conservative Versus Conventional Restorative Approach for Endodontically Treated Posterior Teeth · Moataz Mostafa Anwar
- Oct 2027Bite Force and Occlusal Force Distribution Following Root Canal Treatment. · Chulalongkorn University
Who these studies take
Of the 10 Tooth, Nonvital studies recruiting now, 4 (40%) set no upper age limit and 5 (50%) stop at 75 or younger. 1 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (40%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 8 (80%) | 8 (80%) |
| 30 | 10 (100%) | 10 (100%) |
| 40 | 10 (100%) | 10 (100%) |
| 50 | 10 (100%) | 10 (100%) |
| 65 | 8 (80%) | 8 (80%) |
| 75 | 7 (70%) | 7 (70%) |
| 85 | 4 (40%) | 4 (40%) |
Across all 111 studies, recruiting or not: 76% stop at 75 or younger and 68% at 65; 19% take children; 0% are for women only and 0% for men only; 61% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tooth, Nonvital studies take
Of 60 interventional studies with no phase under Tooth, Nonvital, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo7–36 · 60 studies | — | 19 mo7–36 · 60 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Clinical Comparison of Lithium Disilicate and 3D-Printed Resin EndocrownsOct 15, 2026NCT07874906
Studies
Recruiting first, then most recently updated. Showing 50 of 111. Browse all 111 → or search them.
- Clinical Evaluation of Two Post Systems for Single Crown Restoration of Anterior TeethNot yet recruitingNCT07827755Not applicable1 country
- Conservative Versus Conventional Restorative Approach for Endodontically Treated Posterior TeethRecruitingNCT07836920Not applicable1 country
- Predictable Method for Restoring Endodontically Treated Teeth, Comparing Indirect and Direct Methods and Materials in Aesthetic Dentistry.Not yet recruitingNCT07778563Not applicable
- Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic MicrosurgeryRecruitingNCT06574152Not applicable1 country
- Milled vs 3D-Printed Partial-Coverage Restorations in Endodontically Treated MolarsRecruitingNCT07643311Not applicable1 country
- Additive vs Subtractive Manufacturing for Endocrown Fabrication: A 24-Month RCTNot yet recruitingNCT07633574Not applicable
- Bite Force and Occlusal Force Distribution Following Root Canal Treatment.Not yet recruitingNCT076263721 country
- Clinical Performance of Printed Hybrid Resin in Indirect RestorationsRecruitingNCT07465978Not applicable1 country
- Clinical Success of Onlays Fabricated With Different Types of ResinRecruitingNCT06960070Not applicable1 country
- Comparison of the Clinical Performance of High Strength Hybrid Ceramic Indirect Restorations Cemented on Endodontically Treated Teeth Using Bioactive Versus Conventional Self Adhesive Resin Cements.Not yet recruitingNCT06787469Not applicable
- The Performance of Posterior Partial Coverage Coronal Restorations Luted With Two Differrent Systems.RecruitingNCT06457737Not applicable1 country
- Digital, Conventional, And Biomimetic Approaches for Restoring Endodontically Treated TeethRecruitingNCT06717230Not applicable1 country
- Effectiveness of GentleWave System in Endodontic TreatmentNot yet recruitingNCT06518304Not applicable1 country
- Antimicrobial Efficacy of Nano-Based ICM on E.FRecruitingNCT06533215Not applicable1 country
- No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic TreatmentNot yet recruitingNCT06450938Not applicable
- Single Rotary File System Versus Conventional Manual K-file in Pulpectomy of Primary Molars.Not yet recruitingNCT06151665Not applicable1 country
- Outcome of Endodontic Treatment and Retreatment With a Bioceramic SealerRecruitingNCT04528979Not applicable1 country
- Outcome of Endodontic Retreatment in One or Two VisitsRecruitingNCT04527705Not applicable1 country
- Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not?Active, not recruitingNCT06447519Not applicable1 country
- Shade Matching and Patient Satisfaction of Yttria Stabilized Multilayered Zirconia and Lithium Disilicate RestorationsCompletedNCT06539546Not applicable1 country
- Clinical Comparison of Lithium Disilicate and 3D-Printed Resin EndocrownsActive, not recruitingNCT07874906Not applicable1 country
- Treatment Result of Zirconia Laminate VeneerCompletedNCT06406582Not applicable1 country
- Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp NecrosisCompletedNCT02485210Not applicable1 country
- Alternative EndoCrowns Designs for Chairside CAD/CAMCompletedNCT04604314Not applicable1 country
- Deep Margin Elevation in Endodontically Treated Posterior TeethActive, not recruitingNCT07661719Not applicable1 country
- Long-term Performance and Safety of Biodentine™ in Patients Treated for Endodontic IndicationsActive, not recruitingNCT050847421 country
- Clinical Assessment of CAD/CAM Fabricated Lithium-Disilicate Overlay Versus Lithium-disilicate Endocrowns for Restoration of Endodontically Treated Teeth.CompletedNCT07508475Not applicable1 country
- Endodontic Management of Primary MolarsCompletedNCT04691050Not applicable1 country
- Post Operative Sensitivity of MTA ObturationCompletedNCT067952821 country
- Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible PulpitisCompletedNCT06304259Not applicable1 country
- Composite Restorations Performed by Placing Polyethylene FiberCompletedNCT06346769Not applicable1 country
- Direct Versus Indirect Endocrowns on Endodontically Treated MolarsActive, not recruitingNCT06934460Not applicable
- Evaluation of the Clinical Success of Direct Restorations of Endodontically Treated Posterior Teeth in the Presence of Parafunction: A Pilot StudyCompletedNCT06870188Not applicable1 country
- Outcome of NSRCT Versus VPT in Management of Teeth with Symptomatic Irreversible Pulpitis Associated with Apical PeriodontitisActive, not recruitingNCT06226870Not applicable1 country
- Post-Endodontic Instrumentation Pain After in a Single Session Associated With PhotobiomodulationCompletedNCT06253767Not applicable1 country
- XP-Endo Finisher on Postoperative Pain in Retreatment Cases Using Mtwo R FilesCompletedNCT06625853Not applicable1 country
- A 3-Year Clinical Evaluation Of Endocrown Restorations With Two Different MaterialsActive, not recruitingNCT06311422Not applicable1 country
- Effectiveness of Different Obturation TechniquesCompletedNCT06226740Not applicable1 country
- Clinical Performance of the Indirect Resin Composite Restorations in Endodontically Treated TeethCompletedNCT04561167Not applicable1 country
- Impression & Prosthesis Quality Made From Different Polyvinylsiloxane Impression TechniquesCompletedNCT05938400Not applicable1 country
- Effect of Intra-Canal Cryotherapy on Postoperative Pain After Endodontic ProceduresActive, not recruitingNCT06134713Phase 41 country
- Clinical Performance of Milled Resin Composite in Restoration of Endodontically Treated Posterior Teeth Over One YearCompletedNCT04518371Not applicable1 country
- Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 ExpressionCompletedNCT05603988Not applicable1 country
- Endocrowns in Anterior Teeth: Effect of Cementation Protocols and Restorative Materials on the Clinical Performance of the RestorationsCompletedNCT05973292Phase 21 country
- The Restoration of Endodontically Treated Teeth Using Indirect Full Coverage Restorations Compared to Direct Composite Resin RestorationsActive, not recruitingNCT04249726Not applicable1 country
- Broken Instrument RemovalCompletedNCT05128266
- Turmeric Gel as Alternative Non-vital Pulpotomy Medicament in Primary TeethCompletedNCT05801354Phase 1/21 country
- Allium Sativum Oil as Alternative Non-vital Pulpotomy Medicament in Primary TeethCompletedNCT05801367Phase 1/21 country
- Apical Gap Length and Adaptation of Zirconia Post Using Intraoral and Extraoral Scan of Silicon Impression TechniqueStatus unknownNCT05476419Not applicable
- Effects of Two Different Physical Therapy Protocols After an Endodontic InterventionCompletedNCT05249686Not applicable1 country