An interventional study of CAD/CAM Milled HC Hard Block Endocrown and 3D-Printed VarseoSmile TriniQ Endocrown in Tooth, Nonvital, Dental Restoration and Endodontically Treated Teeth, sponsored by Cairo University. Not yet recruiting. Open to participants aged 25 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-06-08.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This randomized controlled trial (RCT) compares the 24-month clinical performance of endocrown restorations fabricated by two digital manufacturing pathways: additive manufacturing using 3D-printed ceramic-filled photopolymer resin (VarseoSmile TriniQ, BEGO) versus subtractive computer-aided design/computer-aided manufacturing (CAD/CAM) milling from hybrid nano-ceramic blocks (HC Hard Block, Shofu). Sixty endocrowns will be placed in endodontically treated posterior molars and evaluated using modified United States Public Health Service (USPHS) criteria at 6, 12, and 24 months. The trial is conducted at the Conservative Dentistry Department, Faculty of Dentistry, Cairo University.
Post-endodontic rehabilitation of extensively damaged posterior molars using endocrowns represents a minimally invasive alternative to conventional crown-plus-post-and-core approaches. Digital fabrication has advanced both the precision and reproducibility of endocrown manufacture. While computer-aided design/computer-aided manufacturing (CAD/CAM) milled hybrid ceramic endocrowns are well-validated clinically, prospective clinical data comparing 3D-printed definitive restorations to milled counterparts are absent. This trial employs a parallel-group, 1:1 randomized design with triple blinding of participants, outcome assessors, and statistician. All restorations are delivered using Beautilink SA self-adhesive dual-cure resin cement. The primary outcome is fracture resistance at 24 months; secondary outcomes include retention, marginal adaptation, marginal discoloration, surface texture, anatomic form, color match, secondary caries, fabrication time, and patient satisfaction assessed by Visual Analogue Scale (VAS).
111 studies on the registry are indexed under Tooth, Nonvital; 18 are open to participants now.
This study's planned enrollment of 60 is above the median of 50 across 101 interventional studies indexed under Tooth, Nonvital.
Browse Tooth, Nonvital studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Endocrown restoration fabricated by subtractive CAD/CAM milling from HC Hard Block hybrid nano-ceramic (Shofu Inc., Japan), designed using ExoCAD software and milled on a five-axis wet-milling unit. Adhesively cemented using Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).
Device: CAD/CAM Milled HC Hard Block Endocrown
Endocrown restoration fabricated by additive manufacturing using VarseoSmile TriniQ ceramic-filled photopolymer resin (BEGO GmbH \& Co. KG, Germany), printed on a 4K LCD printer at 30-45 degree build angle, post-cured under nitrogen atmosphere. Adhesively cemented using Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).
Device: 3D-Printed VarseoSmile TriniQ Endocrown
Endocrown restoration milled from HC Hard Block hybrid nano-ceramic (Shofu Inc., Japan) using a five-axis wet-milling CAD/CAM unit. Restoration designed with ExoCAD software, finished and glazed per manufacturer protocol, and cemented with Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).
Also known as: CAD/CAM Milled Endocrown
Endocrown restoration 3D-printed using VarseoSmile TriniQ ceramic-filled photopolymer resin (BEGO GmbH \& Co. KG, Germany) on a 4K LCD printer at 30-45 degree build angle. Post-cured under nitrogen atmosphere, surface glazed, and cemented with Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).
Also known as: 3D-Printed Endocrown
Restoration Fracture Resistance
Assessed using modified USPHS criteria: Alpha = absence of fracture; Bravo = minor chip amenable to repair; Charlie = catastrophic fracture, unrestorable
Time frame: 24 months
Retention
Modified USPHS: Alpha = in situ; Bravo = partial displacement; Charlie = complete loss
Time frame: 6, 12, and 24 months
Marginal Discoloration
Modified USPHS: Alpha = absent; Bravo = superficial; Charlie = penetrating
Time frame: 6, 12, and 24 months
Surface Texture
Modified USPHS: Alpha = smooth; Bravo = minor irregularities; Charlie = extensive breakdown
Time frame: 6, 12, and 24 months
Anatomic Form
Modified USPHS: Alpha = conforms to natural contour; Bravo = discrepancy present, dentin intact; Charlie = dentin or base exposed
Time frame: 6, 12, and 24 months
Color Match
Modified USPHS: Alpha = indistinguishable from adjacent tooth; Bravo = minor deviation, clinically acceptable; Charlie = obvious mismatch; Delta = gross color failure
Time frame: 6, 12, and 24 months
Secondary Caries
Modified USPHS: Alpha = absent; Charlie = present
Time frame: 6, 12, and 24 months
Fabrication Time
Time in minutes from CAD design completion to restoration readiness for cementation
Time frame: Periprocedural
Patient Satisfaction
Visual Analogue Scale 0-100 mm; 0 = entirely dissatisfied, 100 = entirely satisfied
Time frame: 6, 12, and 24 months
No study locations are listed for this record.
Plan to share: No
This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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