Tooth Demineralization clinical trials
The registry lists 27 studies for Tooth Demineralization across more than 10 countries. 9 are recruiting or about to start. 11 of them are mainly about Tooth Demineralization (how this is decided). Per ClinicalTrials.gov, last updated 2026-08-21. Counting its 3 narrower conditions too, such as Dental Caries: 1,258 studies, 229 open.
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Who runs them
Cairo University (2) · Ankara Yildirim Beyazıt University (1) · Ain Shams University (1) · Cardenal Herrera University (1) · Universidad Autonoma de San Luis Potosí (1) · Khyber Medical University Peshawar (1) · Universidad Catolica Santiago de Guayaquil (1) · Universidad Nacional de Colombia (1)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Jun 2027Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics · Cardenal Herrera University
Who these studies take
Of the 6 Tooth Demineralization studies recruiting now, 2 (33%) set no upper age limit and 4 (67%) stop at 75 or younger. 5 (83%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (33%) | 2 (33%) |
| 18 | 5 (83%) | 5 (83%) |
| 30 | 3 (50%) | 3 (50%) |
| 40 | 3 (50%) | 3 (50%) |
| 50 | 2 (33%) | 2 (33%) |
| 65 | 2 (33%) | 2 (33%) |
| 75 | 2 (33%) | 2 (33%) |
| 85 | 2 (33%) | 2 (33%) |
Across all 27 studies, recruiting or not: 81% stop at 75 or younger and 78% at 65; 67% take children; 0% are for women only and 0% for men only; 63% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tooth Demineralization studies take
Of 16 interventional studies with no phase under Tooth Demineralization, half reached primary completion within 18 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo6–21 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 27 of 27. search them.
- Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac PatientsRecruitingNCT07069127Not applicable1 country
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed OrthodonticsRecruitingNCT07244991Not applicable1 country
- Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic BracketsNot yet recruitingNCT07355322Not applicable1 country
- Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical StudyNot yet recruitingNCT07329244Not applicable1 country
- Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot LesionsRecruitingNCT07146464Not applicable1 country
- Effectiveness of Two Health Education Interventions in the Prevention of Caries and Gingivitis in Orthodontic PatientsRecruitingNCT05979805Not applicable1 country
- Preventive Effects of Silver Diamine Fluoride on Early Enamel CariesNot yet recruitingNCT06797882Phase 21 country
- Fluoride Delivery to Prevent White Spots During Orthodontic TreatmentRecruitingNCT05005689Phase 41 country
- Evaluation of Optical Coherence Tomography in DentistryRecruitingNCT03753256Not applicable1 country
- Effects of Calcium-Containing Oral Sprays on Fluorescence-Detectable Plaque Area in ChildrenCompletedNCT07269730Not applicable1 country
- Bioactive Versus Non-Bioactive Restorative System in Deep Carious MolarsCompletedNCT06348953Not applicable1 country
- Clinical Efficacy of Chlorhexidine Varnish in Reducing Gingival Hyperplasia, Plaque Accumulation, and White Spot Lesions in Orthodontic PatientsCompletedNCT07115784Not applicable1 country
- Kissing as a Protective Factor Against Acidic pH in SalivaCompletedNCT06501729Not applicable1 country
- "Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children."CompletedNCT07112963Not applicable1 country
- Evaluation of ART Restorations Using Two Different Bulk-Fill Restorative Materials in Primary MolarsCompletedNCT06771362Not applicable1 country
- Hall Technique or Modified Hall Technique of Deep Carious Lesions in Primary MolarsCompletedNCT05220865Not applicable1 country
- Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ ModelCompletedNCT06732518Phase 31 country
- Caries-preventing Effect of a Hydroxyapatite-toothpaste in AdultsCompletedNCT04756557Not applicable1 country
- Evaluation of Esthetic Performance of Resin Infiltration Technique on Enamel LesionsCompletedNCT02896556Not applicable1 country
- Resin Infiltration and Fluoride Varnish Lesion Arresting Efficacy on Non-cavitated Proximal LesionStatus unknownNCT05202665Not applicable1 country
- Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in SituStatus unknownNCT03971084Not applicable
- Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic TreatmentStatus unknownNCT04342858Phase 21 country
- Hydroxyapatite-toothpaste and Enamel Caries in the Primary DentitionCompletedNCT03553966Not applicable1 country
- Compariing a Bioactive Resin Material Used As A Fissure Sealant To A Conventional ResinStatus unknownNCT04052802Not applicable
- RMGI v Composite for Orthodontic BondingCompletedNCT01925924Not applicable2 countries
- Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.CompletedNCT01059058Not applicable1 country
- Addition of Silver Nanoparticles to a Orthodontic Primer in Preventing Enamel Demineralization Adjacent BracketsStatus unknownNCT02400957Phase 31 country