Squamous Intraepithelial Lesions clinical trials
The registry lists 103 studies for Squamous Intraepithelial Lesions across more than 10 countries. 35 are recruiting or about to start. 56 of them are mainly about Squamous Intraepithelial Lesions (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29. Counting its narrower condition Squamous Intraepithelial Lesions of the Cervix too: 108 studies, 39 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
AIDS Malignancy Consortium (8) · Fujian Maternity and Child Health Hospital (5) · Antiva Biosciences (4) · Inovio Pharmaceuticals (4) · Lei Li (4) · Newish Biotech (Wuxi) Co., Ltd. (3) · Medtronic - MITG (2) · Tigris Pharmaceuticals (2)
What is being tested here
Drugs under test in Squamous Intraepithelial Lesions studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 20275-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer · Phase 3 · Boston University
- Dec 2026Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis · Universitair Ziekenhuis Brussel
- Dec 2026Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities · Amplexd Therapeutics, Inc.
- Dec 2026Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated with Imiquimod · Barretos Cancer Hospital
- Dec 2026Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants · Frantz Viral Therapeutics, LLC
- Jan 2027Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16/18 Infection · Second Affiliated Hospital, Zhejiang University, School of Medicine
- May 2027Evaluation of NWRD08 for HPV-16 and/or HPV-18 Related Cervical HSIL · Newish Biotech (Wuxi) Co., Ltd.
- Jun 2027Predictive Biomarkers for Precision Management of Pre-cancerous Cervical Neoplasia · Lund University
- Jun 2027Evaluation of NWRD09 for HPV-16 Related Cervical HSIL · Newish Biotech (Wuxi) Co., Ltd.
- Jul 2027Hair Regrowth Following Partial Thickness Removal of SSCIS · The Cooper Health System
Who these studies take
Of the 22 Squamous Intraepithelial Lesions studies recruiting now, 10 (45%) set no upper age limit and 11 (50%) stop at 75 or younger. 3 (14%) take children under 18. 17 (77%) are for women only and 1 (5%) for men only; 7 (32%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (14%) | 0 (0%) |
| 18 | 12 (55%) | 3 (14%) |
| 30 | 21 (95%) | 4 (18%) |
| 40 | 21 (95%) | 5 (23%) |
| 50 | 19 (86%) | 5 (23%) |
| 65 | 16 (73%) | 5 (23%) |
| 75 | 11 (50%) | 5 (23%) |
| 85 | 10 (45%) | 5 (23%) |
Across all 103 studies, recruiting or not: 43% stop at 75 or younger and 36% at 65; 10% take children; 61% are for women only and 5% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Newly registered1
- Predictive Biomarkers for Precision Management of Pre-cancerous Cervical NeoplasiaOct 26, 2026NCT07895641
Studies
Recruiting first, then most recently updated. Showing 50 of 103. Browse all 103 → or search them.
- CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer TrialRecruitingNCT06949800Phase 22 countries
- Evaluation of a Point-of-Care, AI-Powered Spectroscopy Device for Triage of Suspicious Vulvar Lesions: A Pilot StudyRecruitingNCT078862031 country
- Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16/18 InfectionRecruitingNCT07306247Not applicable1 country
- Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2RecruitingNCT07306260Not applicable1 country
- Papilozumib Vaginal Gel for Exocervical Mucosal Restoration in Women With Human Papillomavirus (HPV)Not yet recruitingNCT07762209Not applicable1 country
- Hair Regrowth Following Partial Thickness Removal of SSCISNot yet recruitingNCT07809191Not applicable
- Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIVNot yet recruitingNCT06233331Phase 11 country
- Evaluation of NWRD09 for HPV-16 Related Cervical HSILNot yet recruitingNCT07712692Phase 21 country
- Hexaminolevulinate Photodynamic Therapy (HAL-PDT) With Deferred Surgery Versus Surgery for High-grade Squamous Intraepithelial Lesions (HSIL)Not yet recruitingNCT07669363Phase 21 country
- Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women.RecruitingNCT029560311 country
- Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic AbnormalitiesRecruitingNCT07572396Phase 21 country
- Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure ProphylaxisRecruitingNCT07029152Not applicable1 country
- Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical CancerRecruitingNCT07480902Not applicable1 country
- Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial LesionsNot yet recruitingNCT07431502Phase 3
- Evaluation of NWRD08 for HPV-16 and/or HPV-18 Related Cervical HSILRecruitingNCT07175662Phase 21 country
- 5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin CancerRecruitingNCT05381597Phase 2/31 country
- NWRD09 for HPV-16 Related Cervical HSILRecruitingNCT07047989Phase 11 country
- Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative ParticipantsRecruitingNCT06206564Phase 21 country
- Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV InfectionRecruitingNCT06052033Not applicable1 country
- Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated with ImiquimodRecruitingNCT06356012Phase 41 country
- Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 MethylationNot yet recruitingNCT067136551 country
- Efficacy of Topical 85% TCA in the Treatment of LSIL After Low-grade Abnormality of Screening Test: a Randomized Controlled TrialEnrolling by invitationNCT06525870Phase 21 country
- Effect of HPV Integration on Prognosis of Young Women With CIN2 in ChinaRecruitingNCT052820951 country
- Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)RecruitingNCT06577311Phase 21 country
- A Multicenter Randomized Controlled Study of Photoelectric Detection in Cervical Cancer ScreeningNot yet recruitingNCT06491888Not applicable1 country
- A Multicenter Real-world Study of Screening of Cervical Cancer Based on Photoelectric DetectionNot yet recruitingNCT064819301 country
- Role of Methylation Test Triage in HPV Positive WomenNot yet recruitingNCT06366516Not applicable1 country
- Laser Ablation in the Treatment of High-grade Cervical LesionsNot yet recruitingNCT06333743Not applicable
- Evaluation Of The Efficacy Of The Combination Of GLIZIGEN® Oral Solution 1/Day And Vaginal Gel 1/Night For 2 Months In Patients With Cervical Intraepithelial Neoplasia Grade 1 (LSIL/CIN-1) Caused By High-Risk Human Papillomavirus (HPV-AR)RecruitingNCT05916911Phase 41 country
- Evaluation of AHCC® for the Clearance of High Risk-HPV Infections in Chinese FemaleRecruitingNCT04633330Not applicable1 country
- Research About Impact of HPV Integration on the Prognosis of Women With Persistent HR-HPV InfectionRecruitingNCT052832391 country
- HPV Viral Load in Predicting the Prognosis of LSILRecruitingNCT050518521 country
- A Multicenter Cohort Study of HPV Viral Load in Predicting the Postoperative Recurrence of HSILRecruitingNCT052827451 country
- COrSIcA: Disease MeasurementNot yet recruitingNCT05858021
- Prognostic Study of HPV Virus Integration in Women With HSILRecruitingNCT057455971 country
- Predictive Biomarkers for Precision Management of Pre-cancerous Cervical NeoplasiaActive, not recruitingNCT078956411 country
- A Clinical Study on the Evaluation of BD114 for the Treatment HPV-16-Related Cervical HSILTerminatedNCT07170254Early Phase 11 country
- Anal High-risk HPV, HSIL, and Microbiome Among Hispanic Peoples Living With HIV (PLWH)Active, not recruitingNCT066519573 countries
- Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV)Active, not recruitingNCT07735039Not applicable1 country
- VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal LesionsCompletedNCT03603808Phase 22 countries
- NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSILCompletedNCT06276101Phase 11 country
- Anal HSIL Screening AlgorithmCompletedNCT05531799Not applicable1 country
- Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial NeoplasiaCompletedNCT05104099Phase 21 country
- Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin LesionsCompletedNCT02059499Phase 32 countries
- The Effectiveness of High Resolution Microendoscopy for People Living With HIVCompletedNCT04563754Phase 1/21 country
- Improving Cervical Cancer Screening in Women Living With HIV Attending Chronic Disease Clinics in Semi-rural TanzaniaCompletedNCT052568621 country
- Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)CompletedNCT06159842Phase 21 country
- REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)CompletedNCT03721978Phase 310 countries
- Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade LesionsCompletedNCT02135419Phase 32 countries
- Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSILCompletedNCT063255921 country