Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 13 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• 18F-FDG PET/CT Versus 18F-FDG PET/MRI in Detecting Locoregional Recurrence 3 Months After CRT in Head and Neck SCCStatus unknownNCT04196985Not applicable
• A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaCompletedNCT04196283Phase 1
• Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral CancerCompletedNCT04191460Phase 2
• A Clinical Trial Evaluating TG4050 in Head and Neck CancerActive, not recruitingNCT04183166Phase 1/2
• Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 ExpressionActive, not recruitingNCT04180371Phase 1/2
• A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other CancersCompletedNCT04180215Phase 1/2
• Neoadjuvant Anti-PD-1 Antibody (Toripalimab) or Combined With Chemotherapy in HNSCC PatientsStatus unknownNCT04164238Phase 2
• Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid TumorsCompletedNCT04157985Phase 3
• Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)Active, not recruitingNCT04152499Phase 1/2
• Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.TerminatedNCT04152018Phase 1
• Evaluation of Tongue Base MucOsectomy & Step sErial SectioningActive, not recruitingNCT04151134
• SCT-I10A Plus Standard Chemotherapy in First-line Recurrent/ Metastatic Head and Neck Squamous Cell CarcinomaStatus unknownNCT04146402Phase 3
• Safety and Efficacy of SCT-I10A in Head and Neck Squamous Cell CarcinomaStatus unknownNCT04146181Phase 2
• A Multilevel Intervention to Improve Timely Cancer Detection and Treatment InitiationActive, not recruitingNCT04141449Phase 2
• Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal CancerWithdrawnNCT04140513Not applicable
• EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCCCompletedNCT04139057Phase 1/2
• Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and NeckWithdrawnNCT04129320Phase 2/3
• Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell CarcinomaActive, not recruitingNCT04124198Not applicable
• A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in ChinaCompletedNCT04121286Phase 1
• The Diagnostic Value of PET/MRI in Head and Neck CancerStatus unknownNCT04117139Not applicable
• Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck CancerTerminatedNCT04110249Not applicable
• Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell CarcinomaTerminatedNCT04106362Phase 2
• Safety and Efficacy of SB 11285 Alone and in Combination With Atezolizumab in Patients With Advanced Solid TumorsCompletedNCT04096638Phase 1
• Study of CX1106 in Patients With Advanced Head and Neck Squamous Cell CarcinomaWithdrawnNCT04093115Phase 2
• sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCCCompletedNCT04091867Phase 1
• Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic MarkersCompletedNCT04086849
• GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid TumorsActive, not recruitingNCT04083599Phase 1/2
• Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck CancerActive, not recruitingNCT04080804Phase 2
• Study of ARRY-614 Plus Either Nivolumab or Nivolumab+IpilimumabActive, not recruitingNCT04074967Phase 1/2
• GB1275 Monotherapy and in Combination With an Anti-PD1 Antibody in Patients With Specified Advanced Solid Tumors or in Combination With Standard of Care in Patients With Metastatic Pancreatic AdenocarcinomaTerminatedNCT04060342Phase 1
• AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell CarcinomaWithdrawnNCT04058145Phase 2
• A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid TumorsCompletedNCT04045496Phase 1
• Alpha Lipoic Acid to Decrease Pain and Side Effects in Concurrent Treatment of HNSCCCompletedNCT04042935Phase 1
• Study of Hypoxia Measured in F-Miso PET/Scan and MRI in Patients With Squamous Cells CarcinomaCompletedNCT04031534Phase 2
• Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid TumorsActive, not recruitingNCT04007744Phase 1
• Body Composition and Prognosis in Head and Neck Squamous Cell Carcinoma (HNSCC)WithdrawnNCT04003025
• Efficacy of an Oral Immunomodulatory Nutrient on Survival During Postoperative Concomitant Chemoradiotherapy in Head and Neck CancerActive, not recruitingNCT04001543Not applicable
• Therapy for High-Risk HPV 16-Positive Oropharynx Cancer PatientsWithdrawnNCT04001413Phase 2
• Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected MalignanciesTerminatedNCT04000529Phase 1
• A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid TumorsCompletedNCT03997968Phase 1/2
• Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized TrialActive, not recruitingNCT03997643Phase 2
• Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.Active, not recruitingNCT03983954Phase 1
• Sintilimab in Combination With Nab-paclitaxel in Patients With HNSCC (Head and Neck Squamous Cell Carcinoma )Status unknownNCT03975270Phase 2
• A Safety Study of SGN-CD47M in Patients With Solid TumorsTerminatedNCT03957096Phase 1
• Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCCCompletedNCT03953443
• Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL)CompletedNCT03946358Phase 2
• Cell-free Tumor DNA in Head and Neck Cancer PatientsStatus unknownNCT03942380Not applicable
• Evaluating Mutations in MET and TP53 Among Patients Diagnosed With Squamous Cell CarcinomaStatus unknownNCT03938012
• Liquid Biopsy in Head and Neck CancerStatus unknownNCT03926468
• WGA in Platinum-refractory HNSCC Underwent NivolumabStatus unknownNCT03917537
• Feasibility of CTCs Isolation for Transcriptomes and Genome Wide Associated Analysis in Post-OP High Risk OSCC Patients.Status unknownNCT03917524
• Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult PatientsActive, not recruitingNCT03916627Phase 2
• Detection of Circulating Tumor DNA in p16- Locally Advanced Head Neck Squamous Cell CarcinomaCompletedNCT03896412Not applicable
• Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)TerminatedNCT03886181Not applicable
• Definitive Concurrent Hypofractionated Rth With Weekly Cisplatin in Locally Advanced SCCHNCompletedNCT03880396
• Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell CarcinomaStatus unknownNCT03877159
• Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck CancerWithdrawnNCT03875053Not applicable
• SCT200 Plus Platinum-based Chemotherapy in Head and Neck Squamous Cell CarcinomaStatus unknownNCT03874741Phase 2
• Fluciclovine F18 PET/CT in Identifying the Origin of Head and Neck Squamous Cell Carcinoma in Patients With Metastatic Cervical Nodal DiseaseCompletedNCT03868020Early Phase 1
• Memory Phenotype and PD-1 Inhibition Response in Oral CancerTerminatedNCT03862066
• Study of TQB2450 in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck（R/M SCCHN）Status unknownNCT03855384Phase 3
• A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid TumorsCompletedNCT03849469Phase 1
• Hyperbaric Radiation Sensitization of Head and Neck CancersStatus unknownNCT03843671Phase 2
• Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response PredictionStatus unknownNCT03843515Phase 1
• Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2CompletedNCT03838601Not applicable
• TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced CancersCompletedNCT03829436Phase 1
• A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell CarcinomaTerminatedNCT03818542Phase 1
• Validation of USPIO-enhanced MRI for Detection of Lymph Node Metastases in Head and Neck CarcinomaStatus unknownNCT03817307Not applicable
• Phase II Trial of Pembrolizumab in Recurrent or Metastatic HNSCCActive, not recruitingNCT03813836Phase 2
• A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid TumorsCompletedNCT03811652Phase 1
• Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck CancerTerminatedNCT03809624Phase 1
• Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell CarcinomaStatus unknownNCT03799744Phase 1
• Vaccination With Flt3L, Radiation, and Poly-ICLCCompletedNCT03789097Phase 1/2
• Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck CancerCompletedNCT03788785Not applicable
• Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral CavityActive, not recruitingNCT03784066Phase 1/2
• Study Evaluating GZ17-6.02 in Patients With Advanced Solid Tumors or in Combination With Capecitabine in Metastatic Hormone Receptor Positive Breast CancerStatus unknownNCT03775525Phase 1
• IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid TumorsCompletedNCT03758781Phase 1
• A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3)CompletedNCT03752398Phase 1
• A Phase 1 Study of [225Ac]-FPI-1434 InjectionTerminatedNCT03746431Phase 1
• SCT200 Injection in Patients With Head and Neck Squamous Cell CarcinomaStatus unknownNCT03744208Phase 2
• Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced MalignanciesCompletedNCT03739931Phase 1
• Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)Active, not recruitingNCT03737734Not applicable
• An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid TumorsCompletedNCT03735628Phase 1
• A Study to Evaluate the Safety and Effectiveness of ILIxadencel Administered Into Tumors in Combination With Checkpoint Inhibitor (CPI) in Patients With ADvanced CancerTerminatedNCT03735290Phase 1
• Radioguided Selective Neck Dissection for Staging and Treatment of Oral Cavity and Oropharyngeal Squamous Cell CarcinomaStatus unknownNCT03727594
• Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHNCompletedNCT03726775Phase 2
• FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/PaclitaxelCompletedNCT03723967Phase 2
• Enteral Omega 3 During Radiotherapy to Improve the Quality of Life and Functionality of Head and Neck Cancer PatientsTerminatedNCT03720158Not applicable
• Safety and Efficacy of SCT200 in Head and Neck Squamous Cell CarcinomaStatus unknownNCT03713372Phase 2
• Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic TherapyActive, not recruitingNCT03712566
• Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)CompletedNCT03695510Phase 2
• VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck CancerActive, not recruitingNCT03690986Phase 1
• Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid TumorsTerminatedNCT03684785Phase 1/2
• Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembrolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1.CompletedNCT03666273Phase 1
• Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell CarcinomaStatus unknownNCT03652142
• A Safety and Tolerability Study of INCAGN02390 in Select Advanced MalignanciesCompletedNCT03652077Phase 1
• Biofeedback Rehabilitation to Improve Speaking and Eating in PublicCompletedNCT03650699Not applicable
• Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid TumorsTerminatedNCT03645928Phase 2
• Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell CarcinomaCompletedNCT03635164Phase 1
• Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted VaccineCompletedNCT03633110Phase 1/2

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