Squamous Cell Carcinoma of Head and Neck: all 1,711 studies

Page 14 of 18. Open to participants first (544), then studies with results posted, then the rest; newest registration first within each.

• A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced MalignanciesCompletedNCT03629756Phase 1
• Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCCCompletedNCT03624231Phase 2
• Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial.CompletedNCT03623646Phase 2
• A Randomized Phase II Study on the Optimization of Immunotherapy in Squamous Carcinoma of the Head and NeckCompletedNCT03620123Phase 2
• Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell LineStatus unknownNCT03619304Not applicable
• Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell CarcinomaCompletedNCT03618654Early Phase 1
• Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell CanerTerminatedNCT03618134Phase 1/2
• Interim Digital PET/CT in Predicting Outcomes for Participants With Locally Advanced Oropharyngeal Cancer Undergoing Chemoradiation TherapyWithdrawnNCT03611205Not applicable
• Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor MalignanciesCompletedNCT03590054Phase 1
• NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 TherapyActive, not recruitingNCT03589339Phase 1
• HPV-E6-Specific Anti-PD1 TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical CancerCompletedNCT03578406Phase 1
• A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and NeckActive, not recruitingNCT03576417Phase 3
• Standard and Delayed FDG PET/CT After Chemoradiation Therapy in Assessing Patients With Metastatic Head and Neck Squamous Cell CancerCompletedNCT03575949Not applicable
• Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity StudyCompletedNCT03575598Early Phase 1
• Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal CancerWithdrawnNCT03575234Phase 1
• Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell CarcinomaCompletedNCT03554967
• QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.CompletedNCT03552718Phase 1
• SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck CarcinomaActive, not recruitingNCT03546582Phase 2
• ctDNA as a Biomarker for Treatment Response in HNSCCCompletedNCT03540563Not applicable
• A Safety and Tolerability Study of INCAGN02385 in Select Advanced MalignanciesCompletedNCT03538028Phase 1
• Salivary Ap4A, SCCA, TROP2 in Oral Cancer PatientsStatus unknownNCT03529604
• Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell CarcinomaCompletedNCT03524326Phase 1
• Multicentric Comparative Study Between a Conventional and an Intensive Follow up Strategy After Treatment of a Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT03519048Phase 3
• Building a Renewed ImaGe After Head & Neck Cancer TreatmentCompletedNCT03518671Not applicable
• A Study of XmAb®20717 in Subjects With Selected Advanced Solid TumorsCompletedNCT03517488Phase 1
• Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and NeckTerminatedNCT03513042
• Metformin in Head and Neck Squamous Cell Carcinoma: Effect on Tissue OxygenationCompletedNCT03510390Not applicable
• Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid TumorsCompletedNCT03509012Phase 1
• Avelumab, Cetuximab, and Palbociclib in Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT03498378Phase 1
• Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid TumorsActive, not recruitingNCT03485209Phase 2
• Postoperative aRCH With Cisplatin Versus aRCH With Cisplatin and Pembrolizumab in Locally Advanced Head and Neck Squamous Cell CarcinomaCompletedNCT03480672Phase 2
• Study of NEO-201 in Solid Tumors Expansion CohortsActive, not recruitingNCT03476681Phase 1/2
• CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced CancersCompletedNCT03454451Phase 1
• Durvalumab Plus Tremelimumab Combined With Proton Therapy for HNSCCStatus unknownNCT03450967Phase 2
• A Phase 1/2 Study of FS118 in Patients With Advanced MalignanciesTerminatedNCT03440437Phase 1/2
• A Study of BB-401 in Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaCompletedNCT03433027Phase 2
• Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCCCompletedNCT03426657Phase 2
• A Retrospective Clinical Study of Apatinib in Combination With Radiotherapy / Chemotherapy Second-line and Above in the Treatment of Recurrent / Metastatic Head and Neck Squamous Cell CarcinomaStatus unknownNCT03424291Phase 2
• Satisfaction and Quality of Life Comparison Between Patients Using Cicaplast Baume B5 Versus Dexeryl for the Management of Cutaneous Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors (iEGFR)CompletedNCT03421912Not applicable
• Functional Outcome After Treatment for Oropharyngeal Squamous Cell CarcinomaStatus unknownNCT03418909
• The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the JawStatus unknownNCT03418454
• Identifying the Predictive Factors of Response to PD-1 or PD-L1 AntagonistsTerminatedNCT03412058Not applicable
• Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCCActive, not recruitingNCT03410615Phase 2
• Radiotherapy Dose Escalation in Locally Advanced Squamous Cell Carcinoma of the Larynx or HypopharynxWithdrawnNCT03388931Phase 4
• An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and NeckWithdrawnNCT03386838Phase 3
• Chemoradiation vs Immunotherapy and Radiation for Head and Neck CancerActive, not recruitingNCT03383094Phase 2
• IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell CarcinomaCompletedNCT03381183Phase 1
• A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based TherapyStatus unknownNCT03356587Phase 2
• Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic StudyStatus unknownNCT03345966Not applicable
• Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)WithdrawnNCT03342352Phase 3
• Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RTActive, not recruitingNCT03340896Phase 3
• Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free FlapsCompletedNCT03340038Not applicable
• Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or MelanomaCompletedNCT03336606Phase 1
• Comparison of Two Concomitant Administration of RT With Cisplatin in Standard Infusion or Fractional InfusionCompletedNCT03330249Phase 2
• Neoadjuvant Pembrolizumab + Epacadostat Prior to Curative Surgical Care for Squamous Cell Carcinoma of the Head and NeckWithdrawnNCT03325465Phase 2
• Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal CarcinomaActive, not recruitingNCT03323463Phase 2
• FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid TumorsCompletedNCT03319459Phase 1
• REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck TumorsCompletedNCT03317327Phase 1/2
• Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell LineCompletedNCT03292822Phase 1
• Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]CompletedNCT03292250Phase 2
• Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACCStatus unknownNCT03291002Phase 1
• Immunotherapy and SBRT for Metastatic Head and Neck CarcinomasCompletedNCT03283605Phase 1/2
• Transoral Robotic Surgery and Tailored Radiotherapy in Unknown Primary and Small Squamous Cell Head and Neck CancerCompletedNCT03281499Not applicable
• A Clinical and Biological Umbrella Protocol for Smoker or Non-smoker Patients With OPML or HNSCCTerminatedNCT03276819Not applicable
• Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and Neck CancerCompletedNCT03268993Not applicable
• A Study of Apatinib and Tegafur Gimeracil Oteracil in Locally Advanced Squamous Cell Carcinoma of the Head and NeckCompletedNCT03267121Phase 2
• Neoadjuvant Immunoradiotherapy in Head & Neck CancerActive, not recruitingNCT03247712Phase 1/2
• Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro Monotherapy or Experiencing SDTerminatedNCT03246685Phase 2
• Window of Opportunity Trial of Nivolumab and Tadalafil in Patients With Squamous Cell Carcinoma of the Head and NeckCompletedNCT03238365Early Phase 1
• QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint InhibitorsActive, not recruitingNCT03228667Phase 2
• New Modalities for Detection of Oropharyngeal CancerCompletedNCT03226613Not applicable
• Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin ChemoradiationCompletedNCT03225157
• Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal CancerActive, not recruitingNCT03224000Phase 2
• A Study of MGD013 in Patients With Unresectable or Metastatic NeoplasmsCompletedNCT03219268Phase 1
• A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic CancerCompletedNCT03212469Phase 1/2
• GlucoCEST MRI in OncologyCompletedNCT03212157Not applicable
• The Diagnosis of NPC Using the Probe-based Confocal Laser EndomicroscopyStatus unknownNCT03202173Not applicable
• the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal CancerStatus unknownNCT03196869Phase 2
• Radiotherapy Combine With Raltitrexed Versus Radiotherapy Alone in Older Patients With HNSCC.Status unknownNCT03196843Phase 4
• Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced CancersCompletedNCT03195699Phase 1
• Broccoli Sprout Extract in Preventing Recurrence in Patients With Tobacco-Related Head and Neck Squamous Cell CancerCompletedNCT03182959Early Phase 1
• Impact of Ribociclib on Head and Neck Squamous Cell CancerTerminatedNCT03179956Early Phase 1
• QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 TherapyWithdrawnNCT03169764Phase 1/2
• PET/MRI in Oropharyngeal Squamous Cell Carcinoma EvaluationStatus unknownNCT03163797
• Study to Assess the Safety of Nivolumab in the Treatment of Metastatic Melanoma, Lung Cancer, Renal Cancer, Squamous Cell Carcinoma of the Head and Neck, and Chronic Hodgkin Lymphoma in Adults in MexicoWithdrawnNCT03161613
• Functional ImaGing of Heterogeneity in Head and Neck Tumors - Validation From Surgical SpecimensCompletedNCT03160495
• Saliva-based Detection of CD44CompletedNCT03148665
• Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell CancerCompletedNCT03144778Phase 1
• Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and NeckTerminatedNCT03139058Not applicable
• Image Guided Surgery for Margin Assessment of Head and Neck Cancer Using Cetuximab-IRDye800CW cONjugateStatus unknownNCT03134846Phase 1/2
• Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)CompletedNCT03129061Phase 1
• Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHNStatus unknownNCT03117257Phase 2
• Dose Finding Study of TNO155 in Adult Patients With Advanced Solid TumorsTerminatedNCT03114319Phase 1
• Pembrolizumab and Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma (PICH Study)WithdrawnNCT03114280Phase 1/2
• Observational Study of Nivolumab in Participants in Germany With Squamous Cell Carcinoma of the Head and Neck (SCCHN) Progressing on or After Platinum-Based TherapyCompletedNCT03114163
• Hepatitis C Virus Detection in Oral Squamous Cell CarcinomaCompletedNCT03109457
• NC-6004 With 5-FU and Cetuximab for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and NeckCompletedNCT03109158Phase 1/2
• Immunotherapy Study of Evofosfamide in Combination With IpilimumabStatus unknownNCT03098160Phase 1
• A Study of Apatinib Plus Tegafur Gimeracil Oteracil in Recurrent/Metastatic Head and Neck CancersStatus unknownNCT03096184Phase 2
• Biomarker-based Study in R/M SCCHNActive, not recruitingNCT03088059Phase 2

← Squamous Cell Carcinoma of Head and Neck overview