Splenomegaly clinical trials

The registry lists 43 studies for Splenomegaly across more than 10 countries. 9 are recruiting or about to start. 10 of them are mainly about Splenomegaly (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.

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A study of drug A after surgery for early breast cancer

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Status

Completed: 17
Recruiting: 7
Terminated: 5
Status unknown: 5
Withdrawn: 3
Active, not recruiting: 3

Phase

Phase 2: 9
Phase 1: 8
Phase 3: 3

Where

United States: 20
France: 7
Canada: 6
China: 5
Germany: 5
United Kingdom: 4

Who runs them

M.D. Anderson Cancer Center (4) · CENTOGENE GmbH Rostock (3) · Sanofi (2) · Fundación Española de Hematología y Hemoterapía (2) · Shanghai Zhongshan Hospital (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · CTI BioPharma (2) · University of British Columbia (2)

What is being tested here

Drugs under test in Splenomegaly studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Ruxolitinib	1	0	3
Pacritinib	0	3	3
Metformin	0	0	1
Ritonavir	0	0	1
Navitoclax	0	0	1
Lenalidomide	0	0	1
Obinutuzumab	0	0	1
AVID-200	0	0	1
Valproic Acid	0	0	1
Pyrimethamine	0	0	1

Drug classes tested here JAK inhibitors 1 open · Tyrosine kinase inhibitors (TKIs) 1 open

Coming up

1phase 3 study under way

3studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 3

Dec 2026A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer · Centre Georges Francois Leclerc
Jan 2027High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly · M.D. Anderson Cancer Center
Oct 2027A Study to Evaluate Safety , Efficacy and Pharmacokinetics of WJ01024 Tablets Combined With Ruxolitinib in Patients With Myelofibrosis · Suzhou Junjing BioSciences Co., Ltd.

Who these studies take

Of the 7 Splenomegaly studies recruiting now, 2 (29%) set no upper age limit and 2 (29%) stop at 75 or younger. 4 (57%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (14%) take healthy volunteers.

Recruiting studies that take each age, of 7
Age	Women	Men
10	2 (29%)	2 (29%)
18	7 (100%)	7 (100%)
30	7 (100%)	7 (100%)
40	7 (100%)	7 (100%)
50	7 (100%)	7 (100%)
65	6 (86%)	6 (86%)
75	6 (86%)	6 (86%)
85	5 (71%)	5 (71%)

Across all 43 studies, recruiting or not: 23% stop at 75 or younger and 14% at 65; 47% take children; 0% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting1

Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung DiseaseOct 15, 2026NCT06869499

Studies

Recruiting first, then most recently updated. Showing 43 of 43. search them.