CClinicalTrials.gg
Status unknownNCT01201655Updated Sep 14, 2010

Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

An observational study in Liver Cirrhosis, Carcinoma, Hepatocellular and Splenomegaly, sponsored by Xijing Hospital. Status unknown at 1 site in China. Open to participants aged 20 Years to 90 Years. Per ClinicalTrials.gov, last updated 2010-09-14.

Sponsored by Xijing Hospital · Observational

The sponsor has not verified this record recently (last verified Jan 2010), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
5,000
Ages
20 Years to 90 Years
Sex
All
01

Study summary

The purpose of this study is to investigate the impact of splenectomy coupled with portal-azygous disconnection on hepatocarcinogenesis in patients with post-hepatitic cirrhosis after hepatitis B or C virus infection by retrospective case-control study,We hope to find a new idear and method to prevent or cure HCC.

Read the detailed description

A case-control study was carried out. The factors studied include age, gender, ascites, hepatic encephalopathy, ALT, AST, TBIL, ALP, GGT, Child-Pugh classification of liver function, and history of splenectomy with portal-azygous disconnection during the treatment of portal hypertension. According to the Child-Pugh classification, these cases were graded as A, B, and C. And according to the ranges of the normal reference values of the data, they were categorized into two groups including a normal group and an abnormal group.The data mainly comes from FMMU and Xi'an jiaotong university from the year of 2002 to 2012.

02

Conditions studied

  • Liver Cirrhosis
  • Carcinoma, Hepatocellular
  • Splenomegaly
  • Laparotomy

Keywords

  • Posthepatitic cirrhosis;
  • Hepatocarcinogenesis;
  • Splenectomy;
03

In context

Carcinoma, Hepatocellular

3,180 studies on the registry are indexed under Carcinoma, Hepatocellular; 953 are open to participants now.

This study's planned enrollment of 5,000 is above the median of 200 across 752 observational studies indexed under Carcinoma, Hepatocellular.

Browse Carcinoma, Hepatocellular studies →

Lead sponsor

Xijing Hospital is the lead sponsor of 465 studies on the registry; 157 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

post-hepatitic cirrhosis with portal hypertension and hypersplenism patients

Inclusion criteria

  • after surgery

Exclusion criteria

Exclusion Criteria:

  • without surgery
05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
5,000 participants (estimated)
06

Study locations

1 of 1 sites recruiting
  • Chen yong
    Xi'an, Shaanxi 710032, China
    • Chen yong, professor · Contact · cheny@fmmu.edu.cn · 13891915509
    • Li zhe, professor · Sub investigator
    Recruiting
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT01201655
Lead sponsor
Xijing Hospital
Collaborators
Air Force Military Medical University, China, Xi'an Jiaotong University
First posted
Sep 14, 2010
Start date
Jan 2010
Primary completion
Dec 2012 (estimated)
Completion
Dec 2012 (estimated)
Last update
Sep 14, 2010

Study contacts

Chen yong, professor
Contact
cheny@fmmu.edu.cn
13891915509
Chen yong, professor
study director · Xia jielai

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2010. You cannot join it, but the record below documents what was studied.

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