Purpura, Thrombotic Thrombocytopenic clinical trials
The registry lists 67 studies for Purpura, Thrombotic Thrombocytopenic across more than 10 countries. 18 are recruiting or about to start. 57 of them are mainly about Purpura, Thrombotic Thrombocytopenic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
Get an email when these change. Save the Purpura, Thrombotic Thrombocytopenic studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Takeda (6) · Assistance Publique - Hôpitaux de Paris (5) · Octapharma (3) · Sanofi (3) · Baxalta now part of Shire (3) · University College, London (3) · The First Affiliated Hospital of Soochow University (2) · Fundación Española de Hematología y Hemoterapía (2)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 0 programmes from 0 companies, 0 with this as their studies’ main aim; 0 with a live phase 3 study; 0 primary completions in the next 12 months.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
| Drug | Leading trial sponsor · rights | Companies, last 5 years |
|---|---|---|
Adrenal Cortex HormonesRecent, limitedEvidence
| — | 11 study |
Anti-CD20 AntibodyRecent, limitedEvidence
| — | 11 study |
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 0 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorised original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Purpura, Thrombotic Thrombocytopenic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Aspirin | 1 | 1 | 1 |
| Bortezomib | 1 | 0 | 1 |
| Rituximab | 0 | 1 | 6 |
| Caplacizumab | 0 | 4 | 5 |
| Apadamtase alfa | 0 | 2 | 4 |
| ARC 1779 | 0 | 0 | 2 |
| Lusutrombopag | 0 | 0 | 2 |
| Cyclosporine | 0 | 1 | 1 |
| Acetylcysteine | 0 | 0 | 1 |
| Danazol | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Mar 2027A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura · Phase 3 · Takeda
- Sep 2027Aspirin for Prophylaxis of TTP · Phase 3 · The First Affiliated Hospital of Soochow University
- May 2027Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP) · University Hospital, Rouen
- Oct 2027Construction of a Database for TTP · The First Affiliated Hospital of Soochow University
Who these studies take
Of the 16 Purpura, Thrombotic Thrombocytopenic studies recruiting now, 12 (75%) set no upper age limit and 1 (6%) stop at 75 or younger. 9 (56%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (50%) | 8 (50%) |
| 18 | 16 (100%) | 16 (100%) |
| 30 | 16 (100%) | 16 (100%) |
| 40 | 16 (100%) | 16 (100%) |
| 50 | 16 (100%) | 16 (100%) |
| 65 | 16 (100%) | 16 (100%) |
| 75 | 15 (94%) | 15 (94%) |
| 85 | 15 (94%) | 15 (94%) |
Across all 67 studies, recruiting or not: 15% stop at 75 or younger and 7% at 65; 39% take children; 1% are for women only and 0% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 67. Browse all 67 → or search them.
- A Study in Children and, Adults With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Treated With AdzynmaRecruitingNCT073530992 countries
- A Study to Learn More About the Treatment of People With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Who Received Recombinant ADAMTS13 (rADAMTS13) as Part of the Early Access ProgramRecruitingNCT074299422 countries
- A Survey of Recombinant ADAMTS13 in Participants With Congenital Thrombotic Thrombocytopenic PurpuraRecruitingNCT064415781 country
- A Pilot Study of Efgartigimod for Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)RecruitingNCT06831058Phase 21 country
- Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)RecruitingNCT069458611 country
- Daratumumab in Immune-mediated Thrombotic Thrombocytopenic PurpuraRecruitingNCT075139481 country
- Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA CenterRecruitingNCT072058611 country
- BCMA-CD19 CAR-T Therapy for Refractory Autoimmune DiseasesRecruitingNCT06794008Phase 21 country
- Longitudinal Cohort of Thrombosis and Hemostasis DiseasesRecruitingNCT067276691 country
- Italian iTTP RegistryRecruitingNCT063767861 country
- Spanish-Portuguese Thrombotic Thrombocytopenic Purpura RegistryRecruitingNCT059144411 country
- A Prospective Study on the Long-Term Vascular Burden in Thrombotic Thrombocytopenic Purpura PatientsRecruitingNCT031876521 country
- Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)RecruitingNCT012572697 countries
- Turkey Thrombotic Thrombocytopenic Purpura Disease Registry: National Multicenter StudyRecruitingNCT059507501 country
- Construction of a Database for TTPRecruitingNCT055717741 country
- Aspirin for Prophylaxis of TTPNot yet recruitingNCT05568147Phase 2/3
- .German TTP-Registry (Thrombotic Thrombocytopenic Purpura)RecruitingNCT053890071 country
- Efficacy and Safety of Bortezomib as First-line Treatment of Acquired TTPNot yet recruitingNCT05135442Phase 41 country
- A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)CompletedNCT05714969Phase 26 countries
- MICROVASCULAR DAMAGE IN THROMBOTIC THROMBOCYTOPENIC PURPURAActive, not recruitingNCT07615244Not applicable1 country
- Retrospective Analysis of the Efficiency of Caplacizumab in the Treatment of aTTPActive, not recruitingNCT049853181 country
- A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic PurpuraActive, not recruitingNCT04683003Phase 311 countries
- Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic PurpuraActive, not recruitingNCT050467172 countries
- A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP)CompletedNCT03393975Phase 39 countries
- Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic PurpuraCompletedNCT05468320Phase 311 countries
- A Trial of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)CompletedNCT04074187Phase 2/31 country
- Platelet Response to Caplacizumab in the Treatment of Acquired Thrombotic Thrombocytopenic PurpuraCompletedNCT058762211 country
- Expanded Access Program of TAK-755 for Congenital Thrombotic Thrombocytopenic Purpura (cTTP)Approved for marketingNCT05770219
- Safety Study of Danazol With Plasma Exchange and Steroids for the Treatment of Thrombotic Thrombocytopenic Purpura (TTP)TerminatedNCT00953771Phase 21 country
- At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic ConditionsCompletedNCT019316441 country
- The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)CompletedNCT00937131Phase 21 country
- Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP)CompletedNCT00713193Phase 31 country
- SABRE: A Single-arm Prospective Study Measuring Safety and Tolerability of SARS-CoV-2 Neutralising Antibodies in High-risk PopulationsWithdrawnNCT05393999Phase 21 country
- Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic PurpuraCompletedNCT02553317Phase 316 countries
- Study to Assess Efficacy and Safety of Anti-von Willebrand Factor (vWF) Nanobody in Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)CompletedNCT01151423Phase 213 countries
- A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI)Status unknownNCT057854681 country
- Study of rADAMTS-13 (SHP655) in the Treatment of Participants With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)CompletedNCT03922308Phase 27 countries
- Follow-up Study for Patients Who Completed Study ALX0681-C301 (Post-HERCULES)CompletedNCT02878603Phase 313 countries
- Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive CareStatus unknownNCT03237819Phase 31 country
- Low Dose Rituximab in Thrombotic Thrombocytopenic PurpuraCompletedNCT01554514Phase 21 country
- The ConNeCT Study: Neurological Complications of TTPStatus unknownNCT049810281 country
- Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)CompletedNCT02216084Phase 17 countries
- Observational Study of the Use of octaplasLG®.CompletedNCT033693141 country
- A Study to Investigate the Efficacy and Safety of Lusutrombopag (S-888711) Tablets Administered to Adults With Immune Thrombocytopenia (ITP)TerminatedNCT01054443Phase 21 country
- Prospective Psychometric Evaluation Study of a Patient-reported Outcomes (PRO) Instrument for Congenital Thrombotic Thrombocytopenic Purpura (cTTP, Upshaw-Schulman Syndrome [USS], Hereditary Thrombotic Thrombocytopenic Purpura [hTTP]CompletedNCT035196722 countries
- An Open-label Safety Study of Lusutrombopag (S-888711) in Adults With Chronic Immune Thrombocytopenia (ITP)TerminatedNCT01129024Phase 21 country
- Romiplostim, Rituximab and Dexamethasone as Frontline Treatment for Immune ThrombocytopeniaStatus unknownNCT04588194Phase 21 country
- Octaplas Adult TTP TrialTerminatedNCT019384041 country
- IdeS in Asymptomatic Antibody-Mediated Thrombotic Thrombocytopenic Purpura (TTP) PatientsTerminatedNCT02854059Phase 21 country
- Early Predictive Factors of Cardiac and Cerebral Involvement in TMACompletedNCT02134171Not applicable1 country