An interventional study of Diacylglycerol oil and Colza Oil in Prediabetes, sponsored by The First Affiliated Hospital of Guangdong Pharmaceutical University. Not yet recruiting at 1 site in China. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by The First Affiliated Hospital of Guangdong Pharmaceutical University · Not applicable, Interventional, and Prevention
This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil, while those in the control arm will consume colza oil. All other lifestyle behaviors will be maintained without modification. The trial will determine the impact of DAG oil consumption on glycemic regulation, lipid metabolism, and body composition in this high-risk population.
999 studies on the registry are indexed under Prediabetic State; 238 are open to participants now.
This study's planned enrollment of 40 is below the median of 65 across 844 interventional studies indexed under Prediabetic State.
Browse Prediabetic State studies →The First Affiliated Hospital of Guangdong Pharmaceutical University is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
A four-week dietary intervention will be implemented, during which participants assigned to the intervention group will replace their habitual cooking oil with diacylglycerol (DAG) oil.
Combination Product: Diacylglycerol oil
Participants assigned to the control group will consume colza oil as their cooking oil throughout a four-week dietary intervention. No other lifestyle habits or dietary behaviors will be altered.
Combination Product: Colza Oil
This study will implement a four-week dietary intervention in which participants assigned to the intervention group will replace their habitual cooking oil with diacylglycerol (DAG) oil. All other lifestyle behaviors will be maintained without modification.
Participants assigned to the control group will consume colza oil as their cooking oil throughout a four-week dietary intervention. No other lifestyle habits or dietary behaviors will be altered.
Continuous Glucose Monitoring (CGM) Data
At baseline, and 4 weeks, investigators will using Continuous Glucose Monitoring (CGM) to monitor the glucose level of participants.
Time frame: up to 4 weeks
weight
At baseline, and 4 weeks, investigators will examine weight.
Time frame: up to 4 weeks
fasting blood glucose
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine fasting blood glucose.
Time frame: At baseline and after 4 weeks of intervention
lipid metabolism
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine total cholesterol, low density lipoprotein, high density lipoprotein, triglyceride.
Time frame: At baseline and after 4 weeks of intervention
HbA1c
At baseline, and 4 weeks, investigators will use automatic electrochemiluminescence analyzer to examine HbA1c.
Time frame: At baseline and after 4 weeks of intervention
intestinal bacteria
At baseline, and 4 weeks, investigators will use 16S rRNA pyrosequencing to examine intestinal bacteria.
Time frame: up to 4 weeks
TIR (time in range)
TIR refers to the time when blood glucose is controlled within a reasonable ( target ) range (3.9\~10.0 mmol/L), measured by continuous glucose monitoring at baseline and 4 weeks.
Time frame: At baseline and after 4 weeks of intervention
sleep quality
Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which comprises seven components (A through G), each scored on a scale of 0-3. The total score ranges from 0 to 21, with higher scores indicating poorer sleep quality.
Time frame: up to 4 weeks
blood pressure
At baseline, and 4 weeks, investigators will test the systolic blood pressure and diastolic blood pressure using automatic digital blood pressure monitor.
Time frame: up to 4 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital of Guangdong Pharmaceutical University