Personality Disorders clinical trials
The registry lists 126 studies for Personality Disorders across more than 10 countries. 24 are recruiting or about to start. 26 of them are mainly about Personality Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04. Counting its 3 narrower conditions too, such as Borderline Personality Disorder: 496 studies, 110 open.
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Who runs them
Norwegian University of Science and Technology (4) · Shalvata Mental Health Center (3) · Icahn School of Medicine at Mount Sinai (3) · Tages Onlus (3) · University of Milano Bicocca (3) · Vrije Universiteit Brussel (2) · Psychiatric Research Unit, Region Zealand, Denmark (2) · Hôpital le Vinatier (2)
What is being tested here
Drugs under test in Personality Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Guanfacine | 0 | 0 | 2 |
| Fluoxetine | 0 | 1 | 1 |
| Dihydrexidine | 0 | 0 | 1 |
| Desipramine | 0 | 0 | 1 |
| Quetiapine | 0 | 1 | 1 |
| Mifepristone | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Physical Activity in the Management of Personality Disorders · Julie Midtgaard
- Dec 2026Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial) · University of Texas Southwestern Medical Center
- Dec 2026Family Connections Transdiagnostic for Relatives of People With Emotional Dysregulation · University of Valencia
- Dec 2026Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy · University Hospital Tuebingen
- Dec 2026Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients · University of Edinburgh
- Dec 2026Long-term Follow-up of Depressive Disorders in Psychiatric Care · Region Skane
- Jan 2027DSM-5 Personality Disorders in Adults With Autism · Parnassia Groep
- Apr 2027Recovery in Telling Life Stories · University of Aarhus
- Oct 2027B-DIT Feasibility Study · De Viersprong
Who these studies take
Of the 18 Personality Disorders studies recruiting now, 14 (78%) set no upper age limit and 4 (22%) stop at 75 or younger. 5 (28%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (17%) | 3 (17%) |
| 18 | 18 (100%) | 18 (100%) |
| 30 | 17 (94%) | 17 (94%) |
| 40 | 17 (94%) | 17 (94%) |
| 50 | 17 (94%) | 17 (94%) |
| 65 | 16 (89%) | 16 (89%) |
| 75 | 14 (78%) | 14 (78%) |
| 85 | 14 (78%) | 14 (78%) |
Across all 126 studies, recruiting or not: 50% stop at 75 or younger and 47% at 65; 23% take children; 5% are for women only and 2% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Personality Disorders studies take
Of 41 interventional studies with no phase under Personality Disorders, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo14–42 · 41 studies | — | 27 mo14–42 · 39 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Sensorimotor Psychotherapy for Personality DisordersOct 16, 2026NCT07342270
Studies
Recruiting first, then most recently updated. Showing 50 of 126. Browse all 126 → or search them.
- Sensory Profile and Early Clinical Signs of Calm Room UsersRecruitingNCT068399501 country
- Sensorimotor Psychotherapy for Personality DisordersRecruitingNCT07342270Not applicable1 country
- Neurocomputational Dynamics of CooperationNot yet recruitingNCT07759973Not applicable1 country
- Metacognitive Interpersonal Therapy for Male Intimate Partner Violence Perpetrators With Personality DisordersNot yet recruitingNCT07846826Not applicable1 country
- DSM-5 Personality Disorders in Adults With AutismRecruitingNCT067261871 country
- Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)RecruitingNCT03906435Not applicable1 country
- Medical Phenotyping of NHS General Adult Psychiatry (GAP) InpatientsRecruitingNCT073983651 country
- Long-term Follow-up of Depressive Disorders in Psychiatric CareRecruitingNCT070782271 country
- Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral TherapyEnrolling by invitationNCT06863909Not applicable1 country
- Physical Activity in the Management of Personality DisordersRecruitingNCT07341438Not applicable1 country
- PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHERecruitingNCT072687681 country
- Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).Not yet recruitingNCT06983002Not applicable1 country
- Evaluation of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) for the Treatment of Borderline Personality DisorderRecruitingNCT06913738Not applicable1 country
- The (Cost-)Effectiveness of Generalist Versus Specialist Treatment for Severe Personality Disorders'RecruitingNCT06789380Not applicable1 country
- Application and Effectiveness of the STEPPS in Patients with BPD, Extending to Their Families with the FC ProgramRecruitingNCT06195553Not applicable1 country
- An Evolutionarily Informed Conceptualization of Personality PathologyRecruitingNCT066238381 country
- Feasibility, Acceptability, and Preliminary Effects of ISTDP for Personality Disorders in a Specialized Psychiatric ClinicEnrolling by invitationNCT06591754Not applicable1 country
- Unfolding Severe and Enduring Eating Disorders (U-SEED)RecruitingNCT065929631 country
- Development of a Model for Digital Monitoring of the Mental State of the Hospitalized PatientRecruitingNCT061827871 country
- Evolutionary Systems Therapy for Personality PathologyRecruitingNCT06415812Not applicable1 country
- Biological Effects of Schema TherapyRecruitingNCT06367907Not applicable1 country
- Norwegian Adult Mental Health RegistryNot yet recruitingNCT06115200
- Evolutionary Systems Therapy for SchizotypyRecruitingNCT05710926Not applicable1 country
- Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.RecruitingNCT050747321 country
- The Impact of the Use of the MAURISSE Application in People Suffering From an Addiction.CompletedNCT05964296Not applicable1 country
- B-DIT Feasibility StudyActive, not recruitingNCT064710101 country
- tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology PatientsCompletedNCT01876524Not applicable1 country
- Computerized Training for Individuals Diagnosed With Obsessive-Compulsive and Related DisordersCompletedNCT03182075Not applicable1 country
- The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective.CompletedNCT06993662Phase 11 country
- Focused Versus Enhanced Cognitive Behavioral Therapy for Treating Women With Bulimia NervosaCompletedNCT00494858Not applicable1 country
- Exploring Equine-Assisted Psychotherapy as an Intervention for Those Who Have Received a Diagnosis of Emotionally Unstable Personality DisorderActive, not recruitingNCT07261033Not applicable1 country
- Clinical Characteristics of Patients Referred to a Substance Abuse Liaison Department in an Academic Hospital, FranceCompletedNCT049160281 country
- Recovery in Telling Life StoriesActive, not recruitingNCT07082777Not applicable1 country
- Family Connections Transdiagnostic for Relatives of People With Emotional DysregulationActive, not recruitingNCT07585955Not applicable1 country
- "Family Connections" for Caregivers of People With Eating Disorders and Personality Disorders.CompletedNCT05404035Not applicable1 country
- MICBT for Non-underweight Adults With Eating DisordersCompletedNCT05503745Not applicable1 country
- Metacognitive Interpersonal Therapy Across Transdiagnostic Eating Disorders, Including UnderweightActive, not recruitingNCT06693089Not applicable1 country
- Aspects of Self-harm - Cognition, Imaging and TreatabilityCompletedNCT049057971 country
- Integrated Mental Health Care and Vocational Rehabilitation to People With to Common Mental DisordersCompletedNCT04432129Not applicable1 country
- Benchmarking and Change Mechanisms in Personality Disorder TreatmentActive, not recruitingNCT068043691 country
- The Staged Treatment in Early Psychosis StudyCompletedNCT02751632Phase 31 country
- The Effects of Schema Therapy in Outpatient Forensic Mental Health Care: a Single Case Multiple-baseline Study.CompletedNCT05523544Not applicable1 country
- Factors Predicting Outcome in Group Treatment of Alcohol Use Disorders (AUDs)Active, not recruitingNCT048229871 country
- Youth to Text or Telehealth for Engagement in HIV CareCompletedNCT03681145Not applicable1 country
- Physical Exercise as Adjunctive Therapy for Affective Disorder and AnxietyActive, not recruitingNCT051573861 country
- Self and Body-esteem in Socio-professional RehabilitationCompletedNCT04436757Not applicable1 country
- The Effectiveness of a Creative Arts en Psychomotor Therapy Intervention for People With Personality Disorders. From Negative Thinking to Positive Acting.CompletedNCT06219122Not applicable1 country
- Dynamics of Psychotherapy and Treatment OutcomesActive, not recruitingNCT07017543Not applicable1 country
- The Prevalence of Personality Disorders in Outpatient Forensic Mental Health in the NetherlandsCompletedNCT064530961 country
- Extreme Challenges - Psychopathology & Treatment Experiences Among Severly Selfharming Inpatients in NorwayCompletedNCT037686741 country