Nociceptive Pain clinical trials
The registry lists 96 studies for Nociceptive Pain across more than 10 countries. 18 are recruiting or about to start. 42 of them are mainly about Nociceptive Pain (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-22. Counting its narrower condition Visceral Pain too: 148 studies, 35 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Aretaieion University Hospital (5) · University Hospital, Lille (4) · Ciusss de L'Est de l'Île de Montréal (4) · Universitätsklinikum Hamburg-Eppendorf (4) · Stanford University (4) · Erasme University Hospital (3) · Centrexion Therapeutics (2) · Samsung Medical Center (2)
What is being tested here
Drugs under test in Nociceptive Pain studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Pain Acceptance Training in Patients Experiencing Emotional Distress and Somatic Symptoms: Examination of Dialectical Thinking as a Mediating Factor · University of Haifa
- Dec 2026Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery · Vasiliki Samartzi
- Jan 2027Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back Pain · Presidio Medical, Inc
- May 2027TAP vs. ESP Blocks for Post-Cesarean Analgesia · Maternity Hospital - State Budgetary Institution of the Rostov Region, Taganrog
- Aug 2027EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial · Guangdong Provincial People's Hospital
- Sep 2027Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain · Second Affiliated Hospital, School of Medicine, Zhejiang University
Who these studies take
Of the 11 Nociceptive Pain studies recruiting now, 5 (45%) set no upper age limit and 3 (27%) stop at 75 or younger. 0 (0%) take children under 18. 2 (18%) are for women only and 0 (0%) for men only; 5 (45%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 9 (82%) | 8 (73%) |
| 30 | 11 (100%) | 9 (82%) |
| 40 | 11 (100%) | 9 (82%) |
| 50 | 11 (100%) | 9 (82%) |
| 65 | 11 (100%) | 9 (82%) |
| 75 | 8 (73%) | 7 (64%) |
| 85 | 6 (55%) | 5 (45%) |
Across all 96 studies, recruiting or not: 46% stop at 75 or younger and 28% at 65; 6% take children; 8% are for women only and 3% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Nociceptive Pain studies take
Of 42 interventional studies with no phase under Nociceptive Pain, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo3–32 · 42 studies | — | 8 mo3–32 · 37 studies |
| Observational | 14 mo10–21 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care UnitWithdrawnOct 16, 2026NCT05399758
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 96. Browse all 96 → or search them.
- Evaluation of Consciousness Depth (qCON) and Analgesia Depth (qNOX) Indices in General AnesthesiaNot yet recruitingNCT07887919
- TAP vs. ESP Blocks for Post-Cesarean AnalgesiaNot yet recruitingNCT07853482Not applicable1 country
- Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological SurgeryRecruitingNCT07846722Not applicable1 country
- FDG PET/MR Imaging of Peripheral Pain GeneratorsRecruitingNCT061716591 country
- Functional Brain MRI to Understand Pain Phenotypes in Knee OsteoarthritisNot yet recruitingNCT07668674Phase 21 country
- Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord InjuryRecruitingNCT064432811 country
- Pain Acceptance Training in Patients Experiencing Emotional Distress and Somatic Symptoms: Examination of Dialectical Thinking as a Mediating FactorRecruitingNCT07067619Not applicable1 country
- Pleasant Touch Perception in Persistent Pain.Not yet recruitingNCT075516871 country
- Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic PainRecruitingNCT07148388Not applicable1 country
- Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional AnesthesiaRecruitingNCT06905340Not applicable1 country
- Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back PainRecruitingNCT06763653Not applicable1 country
- Unveiling Physiological and Psychosocial Pain Components with an Artificial Intelligence Based Telemonitoring ToolRecruitingNCT060445842 countries
- PETMRI for Chronic Pain from Spinal or Peripheral Nerve OriginNot yet recruitingNCT06599151Phase 1
- Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.RecruitingNCT06291363Phase 41 country
- Nociception Level Index (NOL Index) for Obstetrical Pain Assessment Under Epidural Analgesia.RecruitingNCT058987371 country
- PET/MRI in the Diagnosis of Chronic PainRecruitingNCT03556137Phase 11 country
- Consciousness and Nociception During AnesthesiaNot yet recruitingNCT058797311 country
- The Nociception Level (NOL) Index for Pain Assessment in the Adult Intensive Care UnitNot yet recruitingNCT05339737
- Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care UnitWithdrawnNCT053997581 country
- EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled TrialActive, not recruitingNCT07483398Phase 41 country
- Comparison of Different Objective Nociceptive Measurement Methods During SurgeryCompletedNCT052185511 country
- Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric PopulationCompletedNCT070849351 country
- Investigation of Low-intensity Focused Ultrasound PressureTerminatedNCT06343883Not applicable1 country
- Frailty and Chronic Pain Profiles in Patients Aged ≥65 YearsCompletedNCT073738601 country
- Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General AnaesthesiaCompletedNCT02193412Not applicable1 country
- Central Sensitisation in Nociceptive and Neuropathic PainActive, not recruitingNCT073210801 country
- Pain Phenotypes in Patients With Fibromyalgia SyndromeCompletedNCT059417801 country
- Intraoperative Electroencephalographic Biomarkers of Postoperative PainCompletedNCT063133201 country
- Automatic Remifentanil Administration Guided by ANI During Propofol AnesthesiaCompletedNCT03556696Not applicable1 country
- Optical Measurements of the Skin Surface to Infer Distinctions in Myofascial Tissue StiffnessCompletedNCT06390085Not applicable1 country
- Comparison of the Skin Conductance Algesimeter and the Nociception Level Index in the Paediatric Population. An Observational Study.CompletedNCT059985641 country
- Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health OutcomesCompletedNCT05837923Not applicable1 country
- NOL Index in Response to Pacemaker StimulationCompletedNCT066967811 country
- PET/MRI in the Diagnosis of Pediatric Chronic PainCompletedNCT04435821Phase 11 country
- PET/CT Guided Robotic Arm-assisted Pain Palliation in Chronic Nociceptive Low BackacheCompletedNCT05560165Not applicable1 country
- Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoskeletal PainCompletedNCT06393088Not applicable1 country
- Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative PhenotypeTerminatedNCT03422783Not applicable1 country
- Cervical/Thoracic Neuromodulation and Nociceptive ProcessingStatus unknownNCT06367777Not applicable1 country
- Guiding Opioid Administration in Patients With Regional AnesthesiaCompletedNCT06040307Not applicable1 country
- NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus SevofluraneCompletedNCT04567160Phase 41 country
- Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and PainCompletedNCT05425563Not applicable1 country
- Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health OutcomesCompletedNCT05589935Not applicable1 country
- Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection PainCompletedNCT05049577Not applicable1 country
- "MecPain", a New Questionnaire to Assess Chronic Pain Mechanisms.Status unknownNCT057136041 country
- Cervical Neuromodulation and Nociceptive ProcessingCompletedNCT05127200Not applicable1 country
- Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor SurgeryActive, not recruitingNCT05732896Not applicable1 country
- Use of PET/MR Imaging in Chronic PainCompletedNCT03195270Phase 11 country
- Opioid-free Anesthesia in ThyroidectomiesStatus unknownNCT05243940Not applicable1 country
- Association Between Types of Pain and Motor Activities Physical ActivityCompletedNCT052369331 country
- Nociception and BIS Level Monitoring in COVID-19 Patients in the Intensive Care UnitCompletedNCT055791061 country