Neoplasms, Squamous Cell clinical trials
The registry lists 111 studies for Neoplasms, Squamous Cell across more than 10 countries. 19 are recruiting or about to start. 46 of them are mainly about Neoplasms, Squamous Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its 7 narrower conditions too, such as Squamous Cell Carcinoma of Head and Neck: 3,303 studies, 944 open.
Get an email when these change. Save the Neoplasms, Squamous Cell studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Memorial Sloan Kettering Cancer Center (5) · Merck KGaA, Darmstadt, Germany (4) · Genmab (3) · Revolution Medicines, Inc. (3) · M.D. Anderson Cancer Center (3) · Hookipa Biotech GmbH (3) · Shanghai Junshi Bioscience Co., Ltd. (2) · Sesen Bio, Inc. (2)
What is being tested here
Drugs under test in Neoplasms, Squamous Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ordastobart | 1 | 0 | 1 |
| Benmelstobart | 1 | 0 | 1 |
| Cetuximab | 0 | 0 | 5 |
| Pembrolizumab | 0 | 0 | 3 |
| Zalutumumab | 0 | 1 | 3 |
| HB-201 | 0 | 1 | 2 |
| HB-202 | 0 | 1 | 2 |
| Docetaxel | 0 | 0 | 2 |
| Oportuzumab monatox | 0 | 1 | 2 |
| Bevacizumab | 0 | 0 | 1 |
Drug classes tested here Immune checkpoint inhibitors 1 open · Tyrosine kinase inhibitors (TKIs) 4 · Antimitotic agents 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Nov 2026Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients · Jiangxi Provincial Cancer Hospital
- Dec 2026Hypofractionated Radiotherapy for HNSCC in Elderly Patients · Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Mar 2027Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC) · Falo, Louis, MD
- Jul 2027Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP) · National Cancer Institute (NCI)
- Sep 2027A Study of ZW251 in Participants With Advanced Solid Tumors · Zymeworks BC Inc.
- Sep 2027Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base · Sun Yat-sen University
Who these studies take
Of the 14 Neoplasms, Squamous Cell studies recruiting now, 10 (71%) set no upper age limit and 2 (14%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 14 (100%) | 14 (100%) |
| 30 | 14 (100%) | 14 (100%) |
| 40 | 14 (100%) | 14 (100%) |
| 50 | 14 (100%) | 14 (100%) |
| 65 | 14 (100%) | 14 (100%) |
| 75 | 13 (93%) | 13 (93%) |
| 85 | 11 (79%) | 11 (79%) |
Across all 111 studies, recruiting or not: 15% stop at 75 or younger and 1% at 65; 5% take children; 3% are for women only and 1% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 111. Browse all 111 → or search them.
- Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)RecruitingNCT04198766Phase 1/24 countries
- Tumoral Versus Luminal Microbiome in Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT07809100Not applicable1 country
- A Clinical Trial Comparing an Antibody (INCA33890) Versus Pembrolizumab for Squamous Cell Carcinoma of the Head and Neck.Not yet recruitingNCT07876414Phase 2
- Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck CancerRecruitingNCT07773987Phase 21 country
- Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)RecruitingNCT07460765Phase 11 country
- A Study of ZW251 in Participants With Advanced Solid TumorsRecruitingNCT07164313Phase 16 countries
- R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid TumorsRecruitingNCT06398418Phase 11 country
- Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck CancerRecruitingNCT06959082Phase 21 country
- Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC)RecruitingNCT05377905Phase 1/21 country
- Comparing Postoperative Adjuvant Cisplatin Concurrent Chemoradiotherapy With Adjuvant Radiotherapy Alone for Intermediate-risk Head and Neck Squamous Cell CarcinomaRecruitingNCT07125755Phase 31 country
- A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for Advanced Head and Neck CancerRecruitingNCT07457346Phase 21 country
- Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck CancerRecruitingNCT07348887Not applicable1 country
- Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell CarcinomaRecruitingNCT07337161Not applicable1 country
- Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and NeckNot yet recruitingNCT07259915Not applicable1 country
- Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull BaseNot yet recruitingNCT07145931Phase 21 country
- Towards Cure Via Only Ultra-short ICB in CSCCRecruitingNCT06823479Phase 21 country
- Hypofractionated Radiotherapy for HNSCC in Elderly PatientsEnrolling by invitationNCT06768125Not applicable1 country
- Topical Ascorbic Acid for Treatment of Squamous Cell Skin CancerRecruitingNCT05932511Early Phase 11 country
- Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma PatientsRecruitingNCT05252078Phase 21 country
- Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)Active, not recruitingNCT05797246Phase 21 country
- Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for SurgeryActive, not recruitingNCT04391049Phase 11 country
- Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaTerminatedNCT06790966Phase 31 country
- Study to Examine Lesions of the Skin Using Confocal Laser MicroscopyActive, not recruitingNCT065981371 country
- A Study of Toripalimab Injection (JS001) + Cetuximab in Treatment of Advanced Head and Neck Squamous Cell CancerCompletedNCT04856631Phase 1/21 country
- OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell CancerCompletedNCT00076310Phase 21 country
- Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid CancersActive, not recruitingNCT03935893Phase 21 country
- Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)TerminatedNCT04169074Phase 21 country
- Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or MelanomaCompletedNCT03336606Phase 11 country
- A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1SuspendedNCT04908111Phase 1/21 country
- Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell CarcinomaCompletedNCT03370276Phase 1/21 country
- Inhibition of Oral Tumorigenesis by Antitumor BCompletedNCT04278989Early Phase 11 country
- Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and NeckCompletedNCT02979977Phase 21 country
- A Window of Opportunity Study to Assess the Modulation of Biomarkers in Head and Neck Squamous Cell Cancer (HNSCC) By Preoperative Treatment With BYL719CompletedNCT03138070Not applicable1 country
- Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell CarcinomaActive, not recruitingNCT04124198Not applicable1 country
- Using MC1R Genotype to Impact Melanoma Risk BehaviorCompletedNCT03509467Not applicable2 countries
- A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other CancersCompletedNCT04180215Phase 1/23 countries
- Real-world Study of First Line Pembrolizumab- or Nivolumab-treated HPV-positive Recurrent/Metastatic Oropharyngeal Squamous Cell CarcinomaCompletedNCT067716741 country
- Toripalimab or Placebo With Paclitaxel and Cisplatin in Esophageal Squamous Cell CarcinomaCompletedNCT03829969Phase 31 country
- Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid TumorsTerminatedNCT04116320Phase 11 country
- How Consistent is the Output of DERM, When Used to Assess Images of Potentially Cancerous Skin Lesions.CompletedNCT066549991 country
- A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal CancerWithdrawnNCT06513884Phase 2/3
- Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic UncouplingCompletedNCT02083692Early Phase 11 country
- Bispecific PSMAxCD3 Antibody CC-1 in Patients With Squamous Cell Carcinoma of the LungTerminatedNCT04496674Phase 1/21 country
- Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid TumorsCompletedNCT04774952Phase 11 country
- Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different LocationsCompletedNCT04357873Phase 21 country
- Cabozantinib in Combination With Cetuximab in Patients With Recurrent or Metastatic Head and Neck Squamous Cell CancerCompletedNCT03667482Phase 11 country
- PF-06952229 Treatment in Adult Patients With Advanced Solid TumorsTerminatedNCT03685591Phase 11 country
- Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical CancerCompletedNCT02164461Phase 11 country
- Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck CancerCompletedNCT01884623Phase 31 country
- Evaluation of Full-field Coherence Tomography for ex Vivo Staging and Assessment of Superficial Esophageal Squamous Carcinoma: a Pilot StudyCompletedNCT034675291 country