An observational study in Mortality and Muscle Loss, sponsored by Brno University Hospital. Recruiting at 1 site in Czechia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Brno University Hospital · Observational
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasound for measurement the rectus femoris cross sectional area.
All patients will be admitted to participating ICU centers from December 2025 to December 2026 will be screened and enrolled based on the inclusion and exclusion criteria. Informed consent will be requested. Ultrasound measurements will be performed by the same investigator within the first 24h after ICU admission and again on day 7 of the patient´s ICU stay. All patient data will be entered into case report form by a study physician. In the follow-up will be determined 28 mortality.
412 studies on the registry are indexed under Muscular Atrophy; 77 are open to participants now.
This study's planned enrollment of 386 is above the median of 61 across 73 observational studies indexed under Muscular Atrophy.
Browse Muscular Atrophy studies →Brno University Hospital is the lead sponsor of 91 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Critically ill adult patients will be admitted to intensive care unit with suspect length of artificial ventilation more than 48 hours.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Inability to perform ultrasound examination on day 7
9. Inability to perform ultrasound examination on day 7
Relationship between muscle loss and 28 day mortality
Critically ill patients with a ≥10% decrease in rectus femoris cross-sectional area have increased 28 day mortality.
Time frame: 28 days after enrollment
Incidence of a significant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of 10% or more measured by ultrasound.
Time frame: first 7 days of ICU stay
Incidence of an insignificant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of less than 10% measured by ultrasound.
Time frame: first 7 days ICU stay
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Brno University Hospital