An observational study in Mortality and Muscle Loss, sponsored by Brno University Hospital. Not yet recruiting at 1 site in Czechia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-12.
Sponsored by Brno University Hospital · Observational
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasoud for measurement the rectus femoris cross sectional area.
All patients will be admitted to participating ICU centers from December 2025 to December 2026 will be screened and enrolled based on the inclusion and exclusion criteria. Informed consent will be requested. Ultrasound measurements will be performed by the same investigator within the first 24h after ICU admssion and again on day 7 of the patient´s ICU stay. All patient data will be entered into case report form by a study physician. In the follow-up will be determined 28 mortality.
Critically ill adult patients will be admitted to intensive care unit with suspect length of artificial ventilation more than 48 hours.
Exclusion Criteria:
Inability to perform ultrasound examination on day 7
9. Inability to perform ultrasound examination on day 7
Relationship between muscle loss and 28 day mortality
Critically ill patients with a ≥10% decrease in rectus femoris cross-sectional area have increased 28 day mortality.
Time frame: 28 days after enrollment
Incidence of a significant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of 10% or more measured by ultrasound.
Time frame: first 7 days of ICU stay
Incidence of an insignificant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of less than 10% measured by ultrasound.
Time frame: first 7 days ICU stay
Plan to share: No
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This study is not yet recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Brno University Hospital