An interventional study of Neuromuscular Electrical Stimulation (NMES) and High Protein Supplementation in Subarachnoid Hemorrhage, Muscle Atrophy and Inflammation, sponsored by University of Maryland, Baltimore. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by University of Maryland, Baltimore · Not applicable, Interventional, and Treatment
The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls receiving standard of care interventions for nutrition and mobilization. The investigators will accomplish this by studying the effects of a high protein (HPRO) nutritional treatment as well as NMES intervention have upon muscle wasting and motor strength acutely after SAH. This will be addressed in a prospective trial of SAH patients receiving HRPO with NMES as compared to age and severity-matched SAH patients undergoing standard of care interventions for nutrition and mobilization. Additionally, the study will investigate the impact HPRO and NMES interventions have upon inflammatory cytokines and markers of energy balance. Results of this study will establish evidence for precision nutrition plus early exercise to mitigate the catabolic and inflammatory state produced by SAH to improve muscle, metabolic, and health recovery outcomes.
Exclusion criteria:
Patients will receive standard of care mobilization and nutritional supplementation throughout the study period.
Patients will receive high protein supplementation(HPRO) administered within 30 minutes after each NMES session and additionally once at approximately 10 PM.
Device: Neuromuscular Electrical Stimulation (NMES) · Dietary Supplement: High Protein Supplementation
Patients will undergo two 30 minute NMES sessions per day during study period.
Device: Neuromuscular Electrical Stimulation (NMES)
Patients will receive HPRO three times daily during study period
Dietary Supplement: High Protein Supplementation
Neuromuscular electrical stimulation twice daily during study period.
High protein supplementation with whey protein shakes taken three times a day during study period.
Change in muscle layer thickness of the quadriceps muscle as measured by muscle ultrasound scan at the end of study period.
Change in the muscle layer thickness of the quadriceps muscle as measured by ultrasound.
Time frame: 14 days
Plan to share: No
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University of Maryland, Baltimore