Liver Neoplasms clinical trials
The registry lists 1,345 studies for Liver Neoplasms across more than 10 countries. 335 are recruiting or about to start. 533 of them are mainly about Liver Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Carcinoma, Hepatocellular: 4,475 studies, 1,299 open.
ClinicalTrials.gov finds 5,490 studies for Liver Neoplasms. How that becomes 1,344 here
This page counts the studies the registry files under Liver Neoplasms, and those it files under no condition that list Liver Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 5,490Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −2,880Filed under a narrower condition, counted on its own pageCarcinoma, Hepatocellular 2,853 · Fibrolamellar hepatocellular carcinoma 4
- −37List Liver Neoplasms as a condition, but the registry did not file them under itMost often written as “Colon Cancer Liver Metastasis” (10), “Recurrent Childhood Liver Cancer” (7), and “Colorectal Cancer Liver Metastasis” (4). The registry filed them under other conditions only, most often Colorectal Neoplasms (14) and Colonic Neoplasms (9).
- −1,229Match it another way135 name it in the title, 13 in a keyword, and 1,081 by a synonym or other text the search reads.
- 1,344The count on this page52 of them list Liver Neoplasms in their own words; the registry filed them under no condition.
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Status
Who runs them
National Cancer Institute (NCI) (34) · M.D. Anderson Cancer Center (24) · Sun Yat-sen University (23) · Memorial Sloan Kettering Cancer Center (22) · National Taiwan University Hospital (16) · National Institutes of Health Clinical Center (CC) (16) · Bayer (15) · Fuda Cancer Hospital, Guangzhou (14)
What is being tested here
Drugs under test in Liver Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lenvatinib | 8 | 2 | 14 |
| Durvalumab | 5 | 3 | 13 |
| Pembrolizumab | 5 | 1 | 8 |
| Ipilimumab | 4 | 1 | 7 |
| Apatinib | 4 | 0 | 5 |
| Camrelizumab | 4 | 0 | 4 |
| Sintilimab | 3 | 0 | 4 |
| Gallium-68 | 3 | 1 | 3 |
| Bevacizumab | 2 | 2 | 26 |
| Toripalimab | 2 | 0 | 6 |
Drug classes tested here Immune checkpoint inhibitors 23 open · Tyrosine kinase inhibitors (TKIs) 13 open · Antimetabolites 3 open · Angiogenesis inhibitors 2 open · Alkylating agents 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027Regorafenib Combined With Irinotecan Drug-Eluting Beads for Colorectal Cancer Liver Metastases · Phase 3 · Sun Yat-sen University
- Aug 2027Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection · Phase 3 · Memorial Sloan Kettering Cancer Center
- Oct 2027DEBIRI Plus Chemotherapy vs. Chemotherapy Alone in Colorectal Cancer Liver Metastases · Phase 3 · Tehran University of Medical Sciences
- Nov 2026Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors · University Health Network, Toronto
- Nov 2026Dose-escalation of Regorafenib in Advanced Hepatocellular Carcinoma · Instituto do Cancer do Estado de São Paulo
- Nov 2026Optimizing Y90 Therapy for Radiation Lobectomy · Northwestern University
- Dec 2026Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract · Memorial Sloan Kettering Cancer Center
- Dec 2026Safety and Economics of Parenchymal Transection in Minimally Invasive Liver Surgery · University of Molise
- Dec 2026Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC · National Cancer Centre, Singapore
- Dec 2026The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia. · New Phase Ltd.
Who these studies take
Of the 244 Liver Neoplasms studies recruiting now, 138 (57%) set no upper age limit and 69 (28%) stop at 75 or younger. 14 (6%) take children under 18. 1 (<1%) are for women only and 0 (0%) for men only; 34 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (5%) | 11 (5%) |
| 18 | 224 (92%) | 223 (91%) |
| 30 | 237 (97%) | 236 (97%) |
| 40 | 238 (98%) | 237 (97%) |
| 50 | 239 (98%) | 238 (98%) |
| 65 | 238 (98%) | 237 (97%) |
| 75 | 220 (90%) | 219 (90%) |
| 85 | 155 (64%) | 155 (64%) |
Across all 1,345 studies, recruiting or not: 20% stop at 75 or younger and 4% at 65; 8% take children; <1% are for women only and <1% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Liver Neoplasms studies take
Of 99 phase 1 interventional studies under Liver Neoplasms, half reached primary completion within 49 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 49 mo32–65 · 99 studies | 49 mo28–66 · 51 studies | 51 mo33–63 · 48 studies |
| Phase 1/2 | 59 mo44–72 · 33 studies | — | — |
| Phase 2 | 57 mo37–100 · 86 studies | — | 65 mo37–103 · 72 studies |
| Phase 3 | 57 mo38–97 · 30 studies | — | — |
| Interventional, no phase | 39 mo18–73 · 168 studies | — | 44 mo18–82 · 149 studies |
| Observational | 59 mo34–172 · 160 studies | — | 114 mo34–172 · 132 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Study Comparing BGB-B2033 With Sorafenib or Lenvatinib in Advanced Hepatocellular CarcinomaNov 10, 2026NCT07836530
- Theranostic Approach by Early Multigene Sequencing in Advanced Poor Prognosis CancersOct 22, 2026NCT06958224
Results posted3
- Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular CarcinomaOct 28, 2026NCT04658147
- Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular CancerOct 21, 2026NCT03037437
- A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver CancerOct 14, 2026NCT05337137
Newly registered7
- INPACT: Implementation of Nutritional Support and Physical Activity During Cancer TreatmentNov 10, 2026NCT07929597
- NIVO+IPI Neoadjuvant Therapy for Recurrent Resectable HCCNov 5, 2026NCT07919717
- Characterizing Tumor Hypoxia With BOLD-MRI to Predict Y-90 Treatment ResponseNov 4, 2026NCT07916376
- Study Evaluating the Efficacy and Safety of BGB-B2033 in Participants With Advanced Hepatocellular CarcinomaNov 3, 2026NCT07911683
- Development and Utilization of an Integrated Clinical Genomic DatabaseNov 2, 2026NCT07911267
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Studies
Recruiting first, then most recently updated. Showing 50 of 1,345. Browse all 1,345 → or search them.
- Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract CancerNot yet recruitingNCT07793253Phase 21 country
- Study Comparing BGB-B2033 With Sorafenib or Lenvatinib in Advanced Hepatocellular CarcinomaRecruitingNCT07836530Phase 32 countries
- INPACT: Implementation of Nutritional Support and Physical Activity During Cancer TreatmentNot yet recruitingNCT07929597Not applicable1 country
- Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer StudiesRecruitingNCT004510221 country
- Collection of Blood From Patients With CancerRecruitingNCT000342161 country
- Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)RecruitingNCT064864541 country
- CREO - Microwave Ablation Feasibility StudyRecruitingNCT07817147Not applicable1 country
- NIVO+IPI Neoadjuvant Therapy for Recurrent Resectable HCCNot yet recruitingNCT07919717Phase 21 country
- A Phase II Study of Single Tremelimumab With Regular Interval Durvalumab Plus Gemcitabine and Cisplatin in Locally Advanced Unresectable/Metastatic Combined Hepatocellular-cholangiocarcinomaNot yet recruitingNCT06855225Phase 21 country
- Circulating Tumor DNA Methylation-Guided Adjuvant Therapy Decision-Making in Patients With Resectable Colorectal Cancer Liver Metastases After ResectionRecruitingNCT07917104Phase 21 country
- Characterizing Tumor Hypoxia With BOLD-MRI to Predict Y-90 Treatment ResponseNot yet recruitingNCT07916376Not applicable1 country
- Distance-Based Exercise to Preserve Function and Prevent DisabilityRecruitingNCT07059884Not applicable1 country
- Study Evaluating the Efficacy and Safety of BGB-B2033 in Participants With Advanced Hepatocellular CarcinomaNot yet recruitingNCT07911683Phase 2
- Development and Utilization of an Integrated Clinical Genomic DatabaseRecruitingNCT079112671 country
- A DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Glutamine Antagonist DRP-104, Nivolumab, and Ipilimumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)RecruitingNCT07430202Phase 11 country
- Cancer Experience Registry (CER) for Cancer Patients and CaregiversRecruitingNCT023336041 country
- Immune-Related Adverse Events and Clinical Outcomes of First-Line Immunotherapy in Egyptian Patients With Unresectable Hepatocellular CarcinomaNot yet recruitingNCT079044941 country
- A Retrospective Registry of Intelliblate DUAL Channel Microwave AblationNot yet recruitingNCT07900984
- REGULUS: MRI-guided Adaptive SABR for Liver CancersRecruitingNCT07223307Phase 21 country
- A Study to Evaluate ALN-BCAT in Patients With Hepatocellular CarcinomaRecruitingNCT06600321Phase 13 countries
- Breath Research Narrow Validation for Gastrointestinal Cancer DetectionRecruitingNCT077145381 country
- Theranostic Approach by Early Multigene Sequencing in Advanced Poor Prognosis CancersRecruitingNCT06958224Not applicable1 country
- "Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".RecruitingNCT046909721 country
- Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma PatientsRecruitingNCT04933435Not applicable1 country
- Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue FactorsRecruitingNCT074136401 country
- TheraSphere Japan Pre-Market StudyRecruitingNCT07377487Not applicable1 country
- GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor MalignanciesRecruitingNCT05003895Phase 11 country
- Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor MicroenvironmentEnrolling by invitationNCT056009331 country
- Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid TumorsRecruitingNCT06239194Phase 1/21 country
- PD-1 mRNA LNP Vaccine for Advanced Primary Hepatocellular Carcinoma.RecruitingNCT07053072Phase 11 country
- Tumor Cell and DNA Detection in the Blood, Urine, and Bone MarrowRecruitingNCT035519511 country
- Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan CriteriaEnrolling by invitationNCT05185505Phase 42 countries
- Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for ActionRecruitingNCT066002951 country
- Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.RecruitingNCT07227012Phase 1/25 countries
- Yttrium-90 Radiation Segmentectomy for Hepatocellular CarcinomaNot yet recruitingNCT07110233Not applicable1 country
- Non-Contrast Versus Contrast-Enhanced MRI in Colorectal Liver MetastasesNot yet recruitingNCT07857317
- PULSAR Combined With PD-1 Ab and Chemotherapy Plus Bev. for CRLMRecruitingNCT06788171Phase 21 country
- InstaSure™ Non-Invasive Finger-Press Test for Hepatocellular CarcinomaRecruitingNCT078487501 country
- National Liver Cancer Screening TrialRecruitingNCT06084234Phase 41 country
- DESTINY-PANTUMOUR04RecruitingNCT071240001 country
- FMT+ QL1706+Bevacizumab+ XELOX as First-line Treatment for Advanced MSS-type Colorectal Cancer With Liver MetastasisRecruitingNCT06801665Phase 21 country
- Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver NeoplasmsRecruitingNCT039814971 country
- A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)RecruitingNCT06858813Phase 17 countries
- Patients With Cryptogenic HypertransaminasemiaNot yet recruitingNCT078341251 country
- Protoacoustic Imaging For 3D MappingRecruitingNCT078326171 country
- Multimodal Survival Prediction Model for Colorectal Liver Metastases Post-OperationRecruitingNCT078305761 country
- Precision Navigation to Improve Community Cancer Screening ParticipationRecruitingNCT07676383Not applicable1 country
- A Study Evaluating a New Radiation Treatment Workflow (NGDS)RecruitingNCT07824583Not applicable1 country
- Viscoelasticity Imaging to Assess Liver CancerRecruitingNCT044093401 country
- SL-28 for Advanced Solid TumoursRecruitingNCT07341737Phase 1/21 country