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Not yet recruitingNCT07900984DUALUpdated Oct 28, 2026

A Retrospective Registry of Intelliblate DUAL Channel Microwave Ablation

An observational study in Liver Ablation, Liver Cancer and Liver Cancer (Primary and Metastatic), sponsored by Varian, a Siemens Healthineers Company. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-28.

Sponsored by Varian, a Siemens Healthineers Company (part of Siemens Healthineers) · Observational

Updated Oct 28, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
63
Ages
18 Years and older
Sex
All
01

Study summary

This study reviews past patient records from multiple hospitals to learn how safe and effective the IntelliBlate Microwave Ablation System is when used to treat liver tumors with two probes at the same time.

Read the detailed description

This study is a retrospective multi-center registry designed to evaluate the safety and performance of the Intelliblate Microwave Ablation (MWA) System with dual channel simultaneous microwave ablation of the liver.

02

Conditions studied

  • Liver Ablation
  • Liver Cancer
  • Liver Cancer (Primary and Metastatic)

Keywords

  • retrospective registry
  • liver ablation
  • intelliblate
  • dual channel microwave ablation
03

In context

Liver Neoplasms

1,345 studies on the registry are indexed under Liver Neoplasms; 335 are open to participants now.

This study's planned enrollment of 63 is below the median of 200 across 342 observational studies indexed under Liver Neoplasms.

Browse Liver Neoplasms studies →

Lead sponsor

Varian, a Siemens Healthineers Company is the lead sponsor of 29 studies on the registry; 8 are open to participants now.

Of its 8 completed or terminated interventional studies of FDA-regulated products, 4 (50%) have results posted.

First submitted after Varian became part of Siemens Healthineers.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Subjects will have undergone at least one dual channel MWA treatment in the liver using the Intellblate MWA system and have at least 30 days of follow-up for safety and 8 weeks (-4 weeks, +8 weeks) follow-up for complete ablation evaluation

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Undergone at least one MWA treatment in the liver using dual channel ablation on the Intelliblate MWA system.
  • At least 30 days of follow-up post treatment for safety and 8 weeks (-4 weeks, +8 weeks) follow-up for imaging to assess complete ablation.

Exclusion criteria

Exclusion Criteria:

  • Undergone radioembolization or other radiotherapy to the liver.
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
63 participants (estimated)
Patient registry
No

Interventions

  • DeviceIntelliblate Microwave Ablation (MWA) System

    Subjects will have undergone at least one dual channel MWA treatment in the liver using the Intellblate MWA system

06

What researchers measure

Primary outcomes

  1. 30-Day Major Complication Rate

    30-day post-treatment Major Complication Rate (Grade 3 or above) according to CTCAE criteria. This evaluates the safety of the IntelliBlate MWA System using dual-channel simultaneous microwave ablation of the liver.

    Time frame: Treatment to 30 days of follow-up

Secondary outcomes

  1. Complete Ablation Rate

    Complete Ablation Rate based on post-procedure imaging. This evaluates the performance/effectiveness of the IntelliBlate MWA System.

    Time frame: 8 weeks post-treatment, with an allowable window of -4 weeks to +8 weeks

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Laeseke P, Ng C, Ferko N, Naghi A, Wright GWJ, Zhang Y, Laidlaw A, Kalsekar I, Laxmanan B, Ghosh SK, Zhou M, Szapary P, Pritchett M. Stereotactic body radiation therapy and thermal ablation for treatment of NSCLC: A systematic literature review and meta-analysis. Lung Cancer. 2023 Aug;182:107259. doi: 10.1016/j.lungcan.2023.107259. Epub 2023 Jun 2. PubMed 37321074 ↗
  • McClure T, Lansing A, Ferko N, Wright G, Ghosh SK, Raza S, Kalsekar I, Clarke K, Talenfeld A. A Comparison of Microwave Ablation and Cryoablation for the Treatment of Renal Cell Carcinoma: A Systematic Literature Review and Meta-analysis. Urology. 2023 Oct;180:1-8. doi: 10.1016/j.urology.2023.06.001. Epub 2023 Jun 17. PubMed 37331485 ↗
  • Cheng PL, Wu PH, Kao WY, Lai YT, Hsu JC, Chiou JF, Wu MH, Lee HL. Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis. Exp Hematol Oncol. 2023 Apr 12;12(1):37. doi: 10.1186/s40164-023-00400-7. PubMed 37046292 ↗
  • Zhang L, Du F, Zhang Y, Yangdan C, Wang H, Ren L. Microwave ablation is superior to radiofrequency ablation in the treatment of hepatocellular carcinoma below 5 cm - A systematic review and meta-analysis. J Minim Access Surg. 2023 Oct-Dec;19(4):453-458. doi: 10.4103/jmas.jmas_344_22. PubMed 37706417 ↗
  • Dou Z, Lu F, Ren L, Song X, Li B, Li X. Efficacy and safety of microwave ablation and radiofrequency ablation in the treatment of hepatocellular carcinoma: A systematic review and meta-analysis. Medicine (Baltimore). 2022 Jul 29;101(30):e29321. doi: 10.1097/MD.0000000000029321. PubMed 35905207 ↗
  • Pfannenstiel A, Iannuccilli J, Cornelis FH, Dupuy DE, Beard WL, Prakash P. Shaping the future of microwave tumor ablation: a new direction in precision and control of device performance. Int J Hyperthermia. 2022;39(1):664-674. doi: 10.1080/02656736.2021.1991012. PubMed 35465811 ↗
  • Hinshaw JL, Lubner MG, Ziemlewicz TJ, Lee FT Jr, Brace CL. Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation--what should you use and why? Radiographics. 2014 Sep-Oct;34(5):1344-62. doi: 10.1148/rg.345140054. PubMed 25208284 ↗
  • Granata V, Grassi R, Fusco R, Setola SV, Palaia R, Belli A, Miele V, Brunese L, Grassi R, Petrillo A, Izzo F. Assessment of Ablation Therapy in Pancreatic Cancer: The Radiologist's Challenge. Front Oncol. 2020 Nov 27;10:560952. doi: 10.3389/fonc.2020.560952. eCollection 2020. PubMed 33330028 ↗
  • Glassberg MB, Ghosh S, Clymer JW, Qadeer RA, Ferko NC, Sadeghirad B, Wright GW, Amaral JF. Microwave ablation compared with radiofrequency ablation for treatment of hepatocellular carcinoma and liver metastases: a systematic review and meta-analysis. Onco Targets Ther. 2019 Aug 13;12:6407-6438. doi: 10.2147/OTT.S204340. eCollection 2019. PubMed 31496742 ↗
  • Simon CJ, Dupuy DE, Mayo-Smith WW. Microwave ablation: principles and applications. Radiographics. 2005 Oct;25 Suppl 1:S69-83. doi: 10.1148/rg.25si055501. PubMed 16227498 ↗
  • Ahmed M, Brace CL, Lee FT Jr, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011 Feb;258(2):351-69. doi: 10.1148/radiol.10081634. PubMed 21273519 ↗
  • Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF, Goldberg SN. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology. 2003 Feb;226(2):441-51. doi: 10.1148/radiol.2262012198. PubMed 12563138 ↗
  • Dupuy DE, DiPetrillo T, Gandhi S, Ready N, Ng T, Donat W, Mayo-Smith WW. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage I non-small cell lung cancer. Chest. 2006 Mar;129(3):738-45. doi: 10.1378/chest.129.3.738. PubMed 16537876 ↗

Individual participant data

Plan to share: Undecided — Individual participant data could be shared with each site for their own patients upon request.

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Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 28, 2026
Show all 1 update
  1. Oct 28, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07900984
Responsible party
Sponsor
First posted
Oct 28, 2026
Start date
Oct 2026 (estimated)
Primary completion
Feb 2027 (estimated)
Completion
Mar 2027 (estimated)
Last update
Oct 28, 2026

Study contacts

Clinical Trial Manager
Contact
febasusan.sam@siemens-healthineers.com
5102799833
Clinical Trial Manager
Contact
Ashley.Keefe@siemens-healthineers.com
+46 761471751
Ashley Keefe
study director · Varian, a Siemens Healthineers Company

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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