Lethargy clinical trials
The registry lists 41 studies for Lethargy across more than 10 countries. 23 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-17.
Status
- Recruiting
- 19
- Completed
- 15
- Not yet recruiting
- 3
- Terminated
- 2
- Enrolling by invitation
- 1
- Active, not recruiting
- 1
Phase
- Phase 2
- 5
- Phase 1
- 5
- Phase 3
- 2
- Early Phase 1
- 1
- Phase 4
- 1
Where
- United States
- 13
- France
- 13
- Canada
- 4
- China
- 2
- Germany
- 2
- Italy
- 2
Who runs them
Medical University of South Carolina (4) · Centre Hospitalier Universitaire de Nice (4) · Institut National de la Santé Et de la Recherche Médicale, France (3) · Anhui Medical University (2) · University Hospital, Strasbourg, France (2) · Integrative Research Laboratories AB (2) · Sunnybrook Health Sciences Centre (2) · Region Skane (1)
Studies
Recruiting first, then most recently updated. Showing 41 of 41 — search for more.
- The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRDNot yet recruitingNCT06735950Not applicable
- Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and ApathyRecruitingNCT07461220Phase 1/24 countries
- Accelerated rTMS for Apathy in Parkinson's DiseaseRecruitingNCT07399496Not applicable1 country
- Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to OnsetRecruitingNCT06663891Not applicable1 country
- Multidimensional Apathy in Psychiatric Pathologies.RecruitingNCT04757220Not applicable1 country
- Study of the Effects of Atomoxetine on MotivationNot yet recruitingNCT07771595Phase 41 country
- Apathy in Parkinson Disease TMS StudyRecruitingNCT06087926Not applicable1 country
- Accelerated rTMS vs. Sham for Stroke ApathyRecruitingNCT07113067Phase 1/21 country
- In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy.RecruitingNCT03998852Phase 31 country
- SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot StudyNot yet recruitingNCT07468305Not applicable1 country
- Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)RecruitingNCT07404410Not applicable1 country
- rTMS for Apathy Clinical TrialRecruitingNCT05561205Not applicable1 country
- Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant DepressionRecruitingNCT071465031 country
- Targeting Apathy With Music in Parkinson's DiseaseRecruitingNCT05505019Not applicable1 country
- Evaluation of Three Tests to Assess Social Cognition in Huntington DiseaseRecruitingNCT072530381 country
- Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive DisordersRecruitingNCT072370091 country
- Neural Bases of MotivationRecruitingNCT07251816Not applicable1 country
- A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's DiseaseEnrolling by invitationNCT06642454Not applicable1 country
- A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older AdultsRecruitingNCT06919094Not applicable1 country
- Combined Brain Stimulation and Methylphenidate Treatment for Apathy in DementiaRecruitingNCT07279740Phase 21 country
- Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's DiseaseRecruitingNCT07118956Not applicable1 country
- Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital TherapeuticsRecruitingNCT05877885Not applicable1 country
- Does Relative Hypoglycaemia &/or Sleep Disturbance Contribute to the Lethargy Observed in Addison's DiseaseRecruitingNCT055150551 country
- Lifestyle Intervention for Improving Insulin Resistance and Concern for HealthCompletedNCT05649176Not applicable1 country
- Accelerated rTMS for Post-Stroke ApathyCompletedNCT05878457Phase 11 country
- Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.CompletedNCT02496312Not applicable1 country
- Can Subthalamic Stimulation Using Directional Electrodes Improve Postoperative Management in Parkinson's DiseaseCompletedNCT045786783 countries
- Transcranial Magnetic Stimulation for Apathy in Mild Cognitive ImpairmentCompletedNCT03590327Not applicable1 country
- Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based SystemCompletedNCT03272230Not applicable1 country
- Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and ApathyCompletedNCT05178992Phase 1/21 country
- Motivation and MethylphenidateCompletedNCT03190681Early Phase 11 country
- Assessment of Sleep Disturbance in Alzheimer DiseaseCompletedNCT00831298Not applicable1 country
- The Effects of Apathy on Different Forms of FatigueCompletedNCT04573712Not applicable1 country
- A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related ApathyTerminatedNCT04958031Phase 22 countries
- Phase I Trial Evaluating the Pharmacokinetics of Single Ascending Oral Doses of IRL757 in Healthy Elderly VolunteersCompletedNCT06699628Phase 11 country
- Effect of Istradefylline Treatment on Behavioral Measures of Apathy in Parkinson's Disease.TerminatedNCT051821511 country
- Effects of t-DCS and Cognitive Training on Apathy in Elderly With Minor Neurocognitive ImpairmentActive, not recruitingNCT05232877Not applicable1 country
- Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)CompletedNCT05478681Not applicable1 country
- Carbohydrate Rich Drink Reduces Pre-endoscopic Discomfort for Patients Going for Elective Endoscopic ProceduresCompletedNCT05342116Not applicable1 country
- RCT of Efficacy of Amoxicillin Over Ampicillin on Severe PneumoniaCompletedNCT03369093Not applicable1 country
- Lethargic Depression StudyCompletedNCT00064467Phase 31 country