An Early Phase 1 interventional study of Ritalin (methylphenidate)10Mg Tablet and Placebo Oral Tablet in Motivation, Apathy and Impulsive Behavior, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Completed at 1 site in France. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-24.
Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Early Phase 1, Interventional, and Basic science
The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.
Exclusion Criteria:
Drug: Ritalin (methylphenidate)10Mg Tablet · Drug: Placebo Oral Tablet
Drug: Ritalin (methylphenidate)10Mg Tablet · Drug: Placebo Oral Tablet
oral ingestion of 3 tablets in a single-dose
oral ingestion of 3 tablets in a single-dose
coefficient of sensitivity to reward
Parameter characterizing the influence of reward expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).
Time frame: two hours after administration
coefficient of sensitivity to effort
Parameter characterizing the influence of effort expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).
Time frame: two hours after administration
coefficient of sensitivity to punishment
Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).
Time frame: two hours after administration
coefficient of sensitivity to delay
Parameter characterizing the influence of delay expectation onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).
Time frame: two hours after administration
Plan to share: No
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This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Institut National de la Santé Et de la Recherche Médicale, France