Lennox Gastaut Syndrome: all 68 studies

Page 1 of 1. Open to participants first (13), then studies with results posted, then the rest; newest registration first within each.

• A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGSNot yet recruitingNCT07728097Phase 4
• Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut SyndromeNot yet recruitingNCT07568860Not applicable
• EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine TreatmentEnrolling by invitationNCT07555171
• Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGSEnrolling by invitationNCT07225231Not applicable
• A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to EpidiolexNot yet recruitingNCT06924827Phase 4
• The Children's Adaptive Deep Brain Stimulation for Epilepsy TrialRecruitingNCT06924086Not applicable
• A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)Enrolling by invitationNCT06908226Phase 3
• CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut SyndromeNot yet recruitingNCT06738732Phase 1/2
• BMB-101 in Absence Epilepsy and DEERecruitingNCT06401538Phase 2
• Intermediate-Size Expanded Access Protocol (EAP) for LP352AvailableNCT06149663
• Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and AdultsRecruitingNCT05219617Phase 3
• An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut SyndromeRecruitingNCT05066217Phase 3
• An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303AvailableNCT03778424
• A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to FenfluramineTerminatedNCT06422377Phase 3Results posted
• A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut SyndromeTerminatedNCT05163314Phase 3Results posted
• A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut SyndromeCompletedNCT04938427Phase 3Results posted
• Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled SeizuresTerminatedNCT04485104Phase 3Results posted
• A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut SyndromeCompletedNCT03936777Phase 3Results posted
• A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic EncephalopathiesCompletedNCT03650452Phase 2Results posted
• A Study of Soticlestat in Adults and Children With Rare EpilepsiesTerminatedNCT03635073Phase 2Results posted
• A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut SyndromeCompletedNCT03355209Phase 3Results posted
• Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeTerminatedNCT02834793Phase 3Results posted
• The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe EpilepsyTerminatedNCT02815540Phase 1/2Results posted
• Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot StudyCompletedNCT02731300Phase 4Results posted
• Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure DisorderCompletedNCT02318602Phase 3Results posted
• A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224690Phase 3Results posted
• An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut SyndromesCompletedNCT02224573Phase 3Results posted
• Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224560Phase 3Results posted
• Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGSTerminatedNCT01668654Phase 3Results posted
• Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic DrugsCompletedNCT01405053Phase 3Results posted
• Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut SyndromeCompletedNCT01160770Phase 3Results posted
• A Long Term Extension Study of E2080 in Lennox-Gastaut PatientsCompletedNCT01151540Phase 3Results posted
• A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)CompletedNCT01146951Phase 3Results posted
• Clobazam in Patients With Lennox-Gastaut SyndromeCompletedNCT00518713Phase 3Results posted
• A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)Active, not recruitingNCT06719141Phase 3
• Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut SyndromeActive, not recruitingNCT06464653Not applicable
• A Study on Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) in Children, Teenagers and Adults in PortugalWithdrawnNCT06395792
• A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in SpainCompletedNCT05982717
• Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic EncephalopathyCompletedNCT05626634Phase 2
• Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALYActive, not recruitingNCT05485831
• Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): PilotCompletedNCT05437393Not applicable
• Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut SyndromeCompletedNCT05374824
• Study to Investigate LP352 in Subjects With Developmental and Epileptic EncephalopathiesCompletedNCT05364021Phase 1/2
• RNS System LGS Feasibility StudyActive, not recruitingNCT05339126Phase 2
• Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral SolutionActive, not recruitingNCT05044819Phase 4
• Research on Cognitive Effect of Cannabidiol on Dravet Syndrome and Lennox-Gastaut SyndromeGastaut SyndromeStatus unknownNCT04611438Phase 3
• Bioavailability and Food Effect Study of 3 Types of CarisbamateCompletedNCT04520360Phase 1
• Investigation of Cognitive Outcomes With Cannabidiol Oral SolutionWithdrawnNCT04133480Phase 4
• Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut SyndromeCompletedNCT04062981Phase 1
• Long-term Cardiac Monitoring in EpilepsyTerminatedNCT03955432Not applicable
• Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut SyndromeCompletedNCT03731715Phase 1
• A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking CannabidiolCompletedNCT03467113Phase 1
• Turmeric as Treatment in EpilepsyWithdrawnNCT03254680Not applicable
• Cannabidiol in Children With Refractory Epileptic EncephalopathyStatus unknownNCT03024827Phase 1
• The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe EpilepsyWithdrawnNCT02910297
• Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut EpilepsyCompletedNCT02655198Phase 2
• Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut SyndromeStatus unknownNCT02632149Early Phase 1
• Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Participants With Inadequately Controlled Lennox-Gastaut SyndromeWithdrawnNCT02318537Phase 3
• An Extended Access Program (EAP) for PerampanelNo longer availableNCT02307578
• Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeCompletedNCT02175173
• European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS)CompletedNCT01991041
• Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological EffectsWithdrawnNCT01370486Phase 4
• Epilepsy Phenome/Genome ProjectCompletedNCT00552045
• A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With SeizuresCompletedNCT00297349
• A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut SyndromeCompletedNCT00236756Phase 3
• Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut SyndromeCompletedNCT00004776Phase 3
• Ketogenic Diet for Child Epilepsy and Seizure ControlCompletedNCT00004729Not applicable
• Metabolic Abnormalities in Children With EpilepsyCompletedNCT00001325

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