Lennox Gastaut Syndrome clinical trials
The registry lists 68 studies for Lennox Gastaut Syndrome across more than 10 countries. 13 are recruiting or about to start. 39 of them are mainly about Lennox Gastaut Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Takeda (7) · Jazz Pharmaceuticals (7) · Longboard Pharmaceuticals (5) · Eisai Inc. (4) · SK Life Science, Inc. (4) · Eisai Co., Ltd. (2) · Eisai Limited (2) · INSYS Therapeutics Inc (2)
What is being tested here
Drugs under test in Lennox Gastaut Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Nov 2026An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome · Phase 3 · Epygenix
- Feb 2027Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults · Phase 3 · SK Life Science, Inc.
- Nov 2027A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE) · Phase 3 · Longboard Pharmaceuticals
- Nov 2026RNS System LGS Feasibility Study · NeuroPace
- Dec 2026Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut Syndrome · Liankun_Ren
- Jan 2027CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut Syndrome · Alexander Rotenberg
- Feb 2027Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY · Jazz Pharmaceuticals
- Aug 2027Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution · Jazz Pharmaceuticals
Who these studies take
Of the 4 Lennox Gastaut Syndrome studies recruiting now, 0 (0%) set no upper age limit and 4 (100%) stop at 75 or younger. 3 (75%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (75%) | 3 (75%) |
| 18 | 3 (75%) | 3 (75%) |
| 30 | 3 (75%) | 3 (75%) |
| 40 | 3 (75%) | 3 (75%) |
| 50 | 3 (75%) | 3 (75%) |
| 65 | 1 (25%) | 1 (25%) |
| 75 | 0 (0%) | 0 (0%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 68 studies, recruiting or not: 72% stop at 75 or younger and 69% at 65; 91% take children; 0% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 68. Browse all 68 → or search them.
- Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and AdultsRecruitingNCT05219617Phase 316 countries
- A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGSNot yet recruitingNCT07728097Phase 41 country
- A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)Enrolling by invitationNCT06908226Phase 317 countries
- An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut SyndromeRecruitingNCT05066217Phase 310 countries
- Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGSEnrolling by invitationNCT07225231Not applicable1 country
- Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut SyndromeNot yet recruitingNCT07568860Not applicable
- A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to EpidiolexNot yet recruitingNCT06924827Phase 41 country
- EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine TreatmentEnrolling by invitationNCT075551711 country
- An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303AvailableNCT037784241 country
- The Children's Adaptive Deep Brain Stimulation for Epilepsy TrialRecruitingNCT06924086Not applicable1 country
- BMB-101 in Absence Epilepsy and DEERecruitingNCT06401538Phase 21 country
- Intermediate-Size Expanded Access Protocol (EAP) for LP352AvailableNCT061496632 countries
- CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut SyndromeNot yet recruitingNCT06738732Phase 1/21 country
- Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut SyndromeCompletedNCT053748241 country
- Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut EpilepsyCompletedNCT02655198Phase 21 country
- RNS System LGS Feasibility StudyActive, not recruitingNCT05339126Phase 21 country
- A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)Active, not recruitingNCT06719141Phase 317 countries
- A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic EncephalopathiesCompletedNCT03650452Phase 28 countries
- A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut SyndromeCompletedNCT04938427Phase 318 countries
- A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut SyndromeTerminatedNCT05163314Phase 320 countries
- A Study of Soticlestat in Adults and Children With Rare EpilepsiesTerminatedNCT03635073Phase 28 countries
- A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to FenfluramineTerminatedNCT06422377Phase 31 country
- Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral SolutionActive, not recruitingNCT05044819Phase 41 country
- A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in SpainCompletedNCT059827171 country
- A Study on Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) in Children, Teenagers and Adults in PortugalWithdrawnNCT06395792
- Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALYActive, not recruitingNCT054858311 country
- Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut SyndromeActive, not recruitingNCT06464653Not applicable1 country
- Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic EncephalopathyCompletedNCT05626634Phase 22 countries
- A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut SyndromeCompletedNCT03936777Phase 314 countries
- Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled SeizuresTerminatedNCT04485104Phase 33 countries
- An Extended Access Program (EAP) for PerampanelNo longer availableNCT0230757810 countries
- Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): PilotCompletedNCT05437393Not applicable1 country
- A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut SyndromeCompletedNCT03355209Phase 314 countries
- Study to Investigate LP352 in Subjects With Developmental and Epileptic EncephalopathiesCompletedNCT05364021Phase 1/22 countries
- Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut SyndromeCompletedNCT04062981Phase 11 country
- A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking CannabidiolCompletedNCT03467113Phase 11 country
- Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut SyndromeCompletedNCT03731715Phase 11 country
- Cannabidiol in Children With Refractory Epileptic EncephalopathyStatus unknownNCT03024827Phase 11 country
- Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeCompletedNCT021751731 country
- Long-term Cardiac Monitoring in EpilepsyTerminatedNCT03955432Not applicable1 country
- A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224690Phase 33 countries
- Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and AdultsCompletedNCT02224560Phase 34 countries
- Investigation of Cognitive Outcomes With Cannabidiol Oral SolutionWithdrawnNCT04133480Phase 4
- The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe EpilepsyTerminatedNCT02815540Phase 1/21 country
- Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological EffectsWithdrawnNCT01370486Phase 41 country
- Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeTerminatedNCT02834793Phase 37 countries
- An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut SyndromesCompletedNCT02224573Phase 3
- The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe EpilepsyWithdrawnNCT02910297
- Bioavailability and Food Effect Study of 3 Types of CarisbamateCompletedNCT04520360Phase 11 country
- Research on Cognitive Effect of Cannabidiol on Dravet Syndrome and Lennox-Gastaut SyndromeGastaut SyndromeStatus unknownNCT04611438Phase 31 country