Leg Ulcer clinical trials
The registry lists 173 studies for Leg Ulcer across more than 10 countries. 33 are recruiting or about to start. 78 of them are mainly about Leg Ulcer (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Diabetic Foot: 1,526 studies, 301 open.
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Who runs them
ConvaTec Inc. (5) · Firstkind Ltd (4) · Coloplast A/S (4) · Molnlycke Health Care AB (3) · Smith & Nephew, Inc. (3) · Fondation Hôpital Saint-Joseph (3) · Laboratoires URGO (3) · Southwest Regional Wound Care Center (3)
What is being tested here
Drugs under test in Leg Ulcer studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers · Tides Medical
- Nov 2026Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs · C5 Biomedical
- Dec 2026Vacuum Compression Therapy and Tissue Oxygenation in Chronic Leg Ulcers · BTL Industries Ltd.
- Jan 2027Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers · BioLab Holdings
- Jan 2027Borate-based Bioactive Glass Fiber Matrix (BBGFM) in the Treatment of Venus Leg Ulcers (VLU) · ETS Wound Care, LLC
- Jan 2027Dose-Response Structured Calf Muscle Pump Activation Strategies Versus Unsupervised Home Walks · MTI University
- Jan 2027Assessing Connected-Health, Pressure-Monitoring Technology for Improving Compression Therapy in Venous Leg Ulcer Treatment · Feeltect Limited
- Mar 2027Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers. · Samaritan Biologics
- Mar 2027Efficacy and Safety of Light Compression System in the Local Treatment of Mixed Leg Ulcers (PROMETHEE Clinical Investigation) · Laboratoires URGO
- Jun 2027Performance and Safety of Mepilex® Up in Leg and Foot Ulcers and Skin Tears · Molnlycke Health Care AB
Who these studies take
Of the 24 Leg Ulcer studies recruiting now, 21 (88%) set no upper age limit and 1 (4%) stop at 75 or younger. 2 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 20 (83%) | 20 (83%) |
| 30 | 23 (96%) | 23 (96%) |
| 40 | 24 (100%) | 24 (100%) |
| 50 | 24 (100%) | 24 (100%) |
| 65 | 23 (96%) | 23 (96%) |
| 75 | 23 (96%) | 23 (96%) |
| 85 | 22 (92%) | 22 (92%) |
Across all 173 studies, recruiting or not: 3% stop at 75 or younger and 2% at 65; 5% take children; 0% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leg Ulcer studies take
Of 38 interventional studies with no phase under Leg Ulcer, half reached primary completion within 25 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 25 mo11–48 · 38 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Newly registered2
- Vacuum Compression Therapy and Tissue Oxygenation in Chronic Leg UlcersOct 28, 2026NCT07901517
- Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal WoundsOct 14, 2026NCT07872930
Studies
Recruiting first, then most recently updated. Showing 50 of 173. Browse all 173 → or search them.
- Dose-Response Structured Calf Muscle Pump Activation Strategies Versus Unsupervised Home WalksRecruitingNCT07763782Not applicable1 country
- Vacuum Compression Therapy and Tissue Oxygenation in Chronic Leg UlcersRecruitingNCT07901517Not applicable1 country
- Topical Sevoflurane for Treatment of Chronic Leg UlcersRecruitingNCT05303805Phase 41 country
- Controlled Study, Performed to Evaluate the Safety and Efficacy of EscharEx and Its Placebo (Gel Vehicle) Compared to Non-surgical Standard of Care in Participants With Venous Leg Ulcers (VLU)Not yet recruitingNCT06690177Phase 22 countries
- Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal WoundsNot yet recruitingNCT07872930Phase 2
- Total Contact Soft Cast in Diabetic Foot UlcersRecruitingNCT04210089Not applicable1 country
- Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg UlcersRecruitingNCT07364630Not applicable1 country
- Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.RecruitingNCT06826339Phase 41 country
- Assessing Connected-Health, Pressure-Monitoring Technology for Improving Compression Therapy in Venous Leg Ulcer TreatmentRecruitingNCT07152717Not applicable1 country
- Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.RecruitingNCT06437028Not applicable1 country
- Performance and Safety of Mepilex® Up in Leg and Foot Ulcers and Skin TearsNot yet recruitingNCT07782008Not applicable1 country
- Borate-based Bioactive Glass Fiber Matrix (BBGFM) in the Treatment of Venus Leg Ulcers (VLU)Not yet recruitingNCT07647705Not applicable
- Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb IschemiaNot yet recruitingNCT06326203Phase 1/2
- Clinical Trial Evaluating NuShield® Plus Standard of Care (SOC) Versus Standard of Care (SOC) Alone in the Management of Non-Healing Venous Leg Ulcers (VLUs)RecruitingNCT07510412Not applicable1 country
- Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg UlcersRecruitingNCT07294521Early Phase 11 country
- Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot UlcersNot yet recruitingNCT07290673Not applicable1 country
- Modified Platform Trial Assessing Multiple Umbilical Cord-based CAMPs and SOC v SOC Alone in the Treatment of Hard-to-Heal VLUsNot yet recruitingNCT07449988Not applicable
- Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound HealingRecruitingNCT06939686Not applicable1 country
- Correlating Multispectral Near-Infrared Imaging to Standard Vascular DiagnosticsRecruitingNCT068991131 country
- Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg UlcersRecruitingNCT07089602Phase 41 country
- A Real-World Registry of Chronic Wounds and UlcersRecruitingNCT022807331 country
- Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.RecruitingNCT06810726Phase 21 country
- Efficacy and Safety of Light Compression System in the Local Treatment of Mixed Leg Ulcers (PROMETHEE Clinical Investigation)RecruitingNCT06899919Not applicable1 country
- Effectiveness of Musicotherapy in Reducing Pain Induced by Leg Ulcer CareRecruitingNCT06153589Not applicable1 country
- Additional Hyperbaric Oxygen After Lower Extremity AmputationRecruitingNCT03594344Not applicable1 country
- Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot UlcersRecruitingNCT06681428Not applicable1 country
- Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot UlcersRecruitingNCT06550596Not applicable1 country
- Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUsRecruitingNCT06560502Not applicable1 country
- Clinical Trial Evaluating an Amnion Membrane Allograft Intended for Use in the Management of Non- Healing Venous Leg Ulcers Versus Standard Of Care AloneRecruitingNCT06764953Not applicable1 country
- Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUsRecruitingNCT06674980Not applicable1 country
- Comparison of Human Allograft to Apligraf for Venous Leg UlcersEnrolling by invitationNCT020470841 country
- Geko™ KM40C Hydrogel Skin Adhesion Trial (XW-3)Not yet recruitingNCT06084546Not applicable1 country
- Oxygen Wound Therapy Feasibility StudyRecruitingNCT05422248Not applicable1 country
- Tissue Engineered Veins in Patients With Chronic Venous InsufficiencyCompletedNCT03784131Phase 11 country
- Vacuum Compression Therapy for Chronic Lower Limb UlcersCompletedNCT07737184Not applicable1 country
- Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older AdultsCompletedNCT03576989Not applicable1 country
- Haemodynamics Variations of Transcutaneous Oxygen in Patient With Areterio-venous Leg Ulcers Under Venous CompressionCompletedNCT03725111Not applicable1 country
- Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot UlcersCompletedNCT06035536Not applicable1 country
- Clinical Study Evaluating Wound Closure With Endoform™ and Symphony™CompletedNCT06035523Not applicable1 country
- Transcutaneous Application of Gaseous CO2CompletedNCT04561609Not applicable2 countries
- Retrospective, Observationnal Study to Investigate Procedural Analgesia Delivered to Patients With Lacerations, Abrasions, Burns and Leg Ulcers.CompletedNCT073508111 country
- Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers.CompletedNCT07219004Not applicable1 country
- Evaluation of the Efficacy of Multilayer Compression & UrgoStart PlusCompletedNCT060077031 country
- A RCT Evaluating Efficacy of Type-I Collagen Skin Substitute vs. Human Amnion Membrane in Treatment of Venous Leg UlcersCompletedNCT06831760Not applicable1 country
- Research of Prognostic Factors Associated With Healing of Venous Leg UlcersCompletedNCT01673412Not applicable1 country
- Topical Timolol Benefit in Venous UlcersCompletedNCT02422017Phase 21 country
- Electrostimulation System WoundEL for Leg Ulcers Healing (TerminatedNCT04980898Not applicable1 country
- Resolution of Sickle Cell Leg Ulcers With VoxelotorTerminatedNCT05561140Phase 33 countries
- Study to Evaluate the PICO 14 Negative Pressure Wound Therapy System in the Management of Acute and Chronic WoundsTerminatedNCT052346322 countries
- Effect of NIRS-assisted Assessment on Chronic Lower Extremity and Other Chronic Non-healing UlcersTerminatedNCT06702852Not applicable1 country