Isolated Systolic Hypertension clinical trials
The registry lists 35 studies for Isolated Systolic Hypertension across more than 10 countries. 8 are recruiting or about to start. 20 of them are mainly about Isolated Systolic Hypertension (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
BackBeat Medical Inc (3) · Merck Sharp & Dohme LLC (2) · Seoul National University Hospital (2) · Novartis Pharmaceuticals (2) · Shanghai Jiao Tong University School of Medicine (1) · Weill Cornell Medical College in Qatar (1) · Mount Sinai Hospital, Canada (1) · University of Vigo (1)
What is being tested here
Drugs under test in Isolated Systolic Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amlodipine | 1 | 0 | 2 |
| Atorvastatin | 1 | 0 | 1 |
| Valsartan | 0 | 0 | 2 |
| Clonidine | 0 | 0 | 1 |
| Sacubitril valsartan | 0 | 0 | 1 |
| Sacubitril | 0 | 0 | 1 |
| Liraglutide | 0 | 0 | 1 |
| Aliskiren | 0 | 1 | 1 |
| Hydrochlorothiazide | 0 | 0 | 1 |
| Alagebrium | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure · Weill Cornell Medical College in Qatar
- Dec 2026BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT · Orchestra BioMed, Inc
- Mar 2027Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function · University of Minnesota
Who these studies take
Of the 7 Isolated Systolic Hypertension studies recruiting now, 3 (43%) set no upper age limit and 3 (43%) stop at 75 or younger. 0 (0%) take children under 18. 1 (14%) are for women only and 0 (0%) for men only; 1 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 6 (86%) | 5 (71%) |
| 30 | 6 (86%) | 5 (71%) |
| 40 | 6 (86%) | 5 (71%) |
| 50 | 5 (71%) | 5 (71%) |
| 65 | 6 (86%) | 6 (86%) |
| 75 | 4 (57%) | 4 (57%) |
| 85 | 3 (43%) | 3 (43%) |
Across all 35 studies, recruiting or not: 26% stop at 75 or younger and 11% at 65; 3% take children; 3% are for women only and 3% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 35 of 35. search them.
- Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular FunctionRecruitingNCT07109739Not applicable1 country
- Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood PressureRecruitingNCT05903950Not applicable1 country
- BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenTRecruitingNCT06059638Not applicable15 countries
- Clinical Feasibility of Cardiac Neuromodulation Therapy for Heart Failure With Preserved Ejection FractionNot yet recruitingNCT07598760Not applicable1 country
- Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early PregnancyRecruitingNCT047557641 country
- Treatment of Hypertension During SleepRecruitingNCT03457168Not applicable1 country
- Feasibility and Effectiveness of a Ring-type Blood Pressure Measurement DeviceRecruitingNCT06084065Not applicable1 country
- Blood Pressure and Lipids Reduction in High Risk Elderly Patients With Isolated Systolic HypertensionRecruitingNCT05165251Phase 41 country
- A Pilot Study to Determine the Efficacy of a Low Carbohydrate Diet in Treatment of Adolescents With Metabolic SyndromeCompletedNCT00940966Not applicable1 country
- Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-StudyCompletedNCT05086523Phase 1/23 countries
- Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)CompletedNCT04463121Not applicable1 country
- Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and MorbidityWithdrawnNCT018842981 country
- Sympathetic Regulation of Large Artery Stiffness in Humans With ISHCompletedNCT04423627Early Phase 11 country
- Olive Polyphenols in Cardiovascular PreventionCompletedNCT04874961Phase 41 country
- Isolated Systolic Hypertension in the Elderly and Very ElderlyCompletedNCT00751829Phase 31 country
- A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive PatientsTerminatedNCT04467879Not applicable1 country
- Intensive Versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older PeopleCompletedNCT01650402Not applicable1 country
- TEC4Home Stroke - Feasibility of Home Telemonitoring Technology in Managing Hypertension Among Stroke/TIA PatientsCompletedNCT037120331 country
- A Single Rising Dose Study of MK-8150 (MK-8150-001)CompletedNCT01590810Phase 1
- A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8150 (MK-8150-002)CompletedNCT01656408Phase 1
- Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial DysfunctionTerminatedNCT00802893Phase 21 country
- Systolic Hypertension in Europe Placebo-Controlled TrialTerminatedNCT02088450Phase 2
- SER100 in Isolated Systolic HypertensionCompletedNCT01987284Phase 24 countries
- An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic HypertensionCompletedNCT01281306Phase 29 countries
- Valsartan in Elderly Isolated Systolic Hypertension StudyCompletedNCT00151229Phase 41 country
- Blood Pressure Outcomes With Liraglutide TherapyCompletedNCT01755572Phase 41 country
- Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic HypertensionStatus unknownNCT02270216Not applicable1 country
- Improved Self Management in Uncontrolled Systolic HypertensionStatus unknownNCT02032719Phase 31 country
- A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the ElderlyCompletedNCT00368277Phase 31 country
- Valsartan/Amlodipine As Compared to Losartan Treatment in Stage 2 Systolic HypertensionCompletedNCT00931710Phase 41 country
- Perioperative Myocardial Ischemia in Isolated Systolic HypertensionCompletedNCT012376521 country
- STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISHCompletedNCT00277875Phase 21 country
- Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive PatientsStatus unknownNCT00533858Phase 41 country
- Sports in Hypertension of the ElderlyCompletedNCT00315224Not applicable1 country
- An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With HypertensionCompletedNCT00185068Phase 41 country