Intestinal Failure clinical trials
The registry lists 64 studies for Intestinal Failure across more than 10 countries. 17 are recruiting or about to start. 41 of them are mainly about Intestinal Failure (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Who runs them
VectivBio AG (4) · Boston Children's Hospital (3) · Jinling Hospital, China (3) · The Hospital for Sick Children (3) · Rigshospitalet, Denmark (3) · Institute of Oncology Ljubljana (2) · Hospices Civils de Lyon (2) · University Hospital, Ghent (1)
What is being tested here
Drugs under test in Intestinal Failure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Oct 2027Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome. · Phase 3 · VectivBio AG
- Feb 2027AI-driven Total Parenteral Nutrition Platform · Takeoff41, Inc.
- Jun 2027KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure · SterileCare Inc.
- Aug 2027Effects of Whey Protein and Resistance Training on Muscle Mass in Patients With Intestinal Failure · Wang Xinying
Who these studies take
Of the 12 Intestinal Failure studies recruiting now, 5 (42%) set no upper age limit and 6 (50%) stop at 75 or younger. 7 (58%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (33%) | 4 (33%) |
| 18 | 11 (92%) | 11 (92%) |
| 30 | 8 (67%) | 8 (67%) |
| 40 | 8 (67%) | 8 (67%) |
| 50 | 8 (67%) | 8 (67%) |
| 65 | 8 (67%) | 8 (67%) |
| 75 | 6 (50%) | 6 (50%) |
| 85 | 6 (50%) | 6 (50%) |
Across all 64 studies, recruiting or not: 48% stop at 75 or younger and 41% at 65; 47% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Intestinal Failure studies take
Of 17 interventional studies with no phase under Intestinal Failure, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo12–59 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 64. Browse all 64 → or search them.
- Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBSRecruitingNCT07197944Phase 314 countries
- Spectral Lighting and MetabolismEnrolling by invitationNCT06094504Not applicable1 country
- Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral SupportRecruitingNCT06910943Phase 2/36 countries
- Effects of Whey Protein and Resistance Training on Muscle Mass in Patients With Intestinal FailureNot yet recruitingNCT07759271Not applicable
- A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel SyndromeRecruitingNCT05535361Not applicable1 country
- A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)RecruitingNCT07742735Phase 322 countries
- Resting Energy Expenditure by Gastrointestinal Functional StatusRecruitingNCT07714499Not applicable1 country
- Weaning is Winning? (WeWin Study)RecruitingNCT065257531 country
- KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal FailureRecruitingNCT05879835Not applicable1 country
- Prospective Multisite Study of Quality of Life in Pediatric Intestinal FailureRecruitingNCT046290142 countries
- The LIFT-ECHO Last Mile ProjectNot yet recruitingNCT07094308Not applicable2 countries
- Anabolic Response To Intravenous Amino Acids In Chronic Intestinal Failure PatientsRecruitingNCT07422792Not applicable1 country
- Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery PatientsNot yet recruitingNCT07422246Not applicable1 country
- AI-driven Total Parenteral Nutrition PlatformRecruitingNCT07414576Not applicable1 country
- Effect of Parenteral Support on FibroScan in Short Bowel SyndromeNot yet recruitingNCT072060041 country
- A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).RecruitingNCT05919680Phase 21 country
- Effect of Nocturnal Parenteral Nutrition on Bone Turnover and Energy MetabolismRecruitingNCT05868785Not applicable1 country
- Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN PatientsActive, not recruitingNCT04559334Not applicable1 country
- Effects of Oral Citrulline on Protein Metabolism in Patients With Intestinal Failure (Citrugrêle 2)CompletedNCT01386034Phase 31 country
- Effect of GLP-1 on Intestinal Barrier Function in SBS-IF Patients: A Preliminary Exploration.CompletedNCT07297238Not applicable1 country
- 8.4% Sodium Bicarbonate Locks in Intestinal FailureCompletedNCT05813535Phase 21 country
- Video Training Supplementation for Patients Discharged on Home Parental NutritionCompletedNCT06169774Not applicable1 country
- CGM-Assisted Management of PNCompletedNCT059021041 country
- Chyme Reinfusion for Type 2 Intestinal FailureCompletedNCT04577456Not applicable2 countries
- Optimised Osmolality in Oral Supplements Optimised Osmolality in Oral SupplementsCompletedNCT07231666Not applicable1 country
- Functional Sucrase Deficiency in Short Bowel Syndrome Patients With Intestinal FailureTerminatedNCT04604275Phase 21 country
- Effect of Parenteral Nutrition With n-3 PUFAs on Patients With Intestinal FailureCompletedNCT03869957Not applicable1 country
- Risk Factors for Catheter-Related Bloodstream Infections in Hospitalized Intestinal Failure PatientsCompletedNCT071727111 country
- Characterization of the Long-term Safety, Efficacy, and Pharmacodynamics Revestive® in the Management of Short Bowel Syndrome Pediatric PatientsCompletedNCT03562130Phase 41 country
- Effect of Vitamin D on Skeletal Muscle Function and Qol in Patients With Chronic Intestinal Failure/InsufficiencyCompletedNCT06283615Not applicable1 country
- Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.Active, not recruitingNCT05018286Phase 318 countries
- Metabolic Balance Study of Apraglutide in Patients With Short Bowel Syndrome, Intestinal Failure (SBS-IF) and Colon-in-Continuity (CIC)CompletedNCT04964986Phase 22 countries
- Intralipid Versus SMOFlipid in HPN PatientsCompletedNCT03773237Not applicable1 country
- Changing the Future of Intestinal Failure in Intestinal Chronic Inflammation (INT-FAIL)Active, not recruitingNCT06777251Not applicable1 country
- Overview of Botriomycoma in Children with a Central Line: Epidemiology, Risk Factors, TreatmentsActive, not recruitingNCT067086891 country
- Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IFCompletedNCT04627025Phase 318 countries
- Clinical Trial Comparing TaurolockTMHep100 (Taurolidine 1.35%) and 0.9% Saline As Prevention of Recurrent Catheter-related Bloodstream InfectionsCompletedNCT06660641Not applicable1 country
- Sodium Citrate 4% Locking Solution for Children Requiring Home Parenteral NutritionTerminatedNCT04756427Phase 41 country
- Level of Deprivation Assessment in a Population of Short-bowel Syndrome Patients With Intestinal FailureCompletedNCT063917621 country
- Bone Markers in Pediatric IFCompletedNCT059092281 country
- Infant & Toddler Short Gut Feeding Outcomes StudyCompletedNCT019465031 country
- S. Aureus Decolonization in HPN Patients.TerminatedNCT03173053Not applicable2 countries
- Longitudinal Evaluation of the Impact of Parenteral NutritionCompletedNCT042344901 country
- Development of a Patient Reported Outcome Measure for GastroIntestinal RecoveryStatus unknownNCT053157651 country
- Plasma Citrulline Level in Relation to Absorptive SurfaceCompletedNCT00286039Not applicable1 country
- Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective Nested Matched Pair AnalysisStatus unknownNCT047330661 country
- Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated CholestasisNo longer availableNCT021481461 country
- Perception of Needs of Patients With Chronic Intestinal Failure and Their Practitioners: a Qualitative StudyStatus unknownNCT04390633
- Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure PatientsCompletedNCT025618191 country
- Safer Parenteral Nutrition in Pediatric Short Bowel Syndrome to Decrease Liver DamageApproved for marketingNCT018618341 country