An interventional study of Intravenous Amino Acids in Chronic Intestinal Failure, Intestinal Failure and Home Parenteral Nutrition, sponsored by Institute of Oncology Ljubljana. Recruiting at 1 site in Slovenia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-20.
Sponsored by Institute of Oncology Ljubljana · Not applicable, Interventional, and Other
The purpose of this study is to gain insight into the actual protein requirements of patients with chronic intestinal failure (CIF) receiving home parenteral nutrition, which could improve clinical management of these patients. Based on collected data on protein kinetics, the study aims to further refine and personalize nutritional mixtures in patients with CIF. Additional aims include assessment of short-chain fatty acid metabolism and evaluation of gut microbiota function in patients with CIF.
This prospective cohort study evaluates anabolic response to intravenous amino acid administration and metabolic phenotype in patients with chronic intestinal failure (CIF) receiving home parenteral nutrition. The study aims to improve therapy of CIF patients by providing new insights into metabolism and anabolic response. Protein kinetics will be assessed to better define protein requirements and to support optimization and personalization of parenteral nutrition mixtures. The study will also assess short-chain fatty acid metabolism and provide insight into gut microbiota function in CIF patients.
64 studies on the registry are indexed under Intestinal Failure; 17 are open to participants now.
This study's planned enrollment of 40 is close to the median of 38 across 42 interventional studies indexed under Intestinal Failure.
Browse Intestinal Failure studies →Institute of Oncology Ljubljana is the lead sponsor of 81 studies on the registry; 26 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.
Patients with chronic intestinal failure receiving home parenteral nutrition receive intravenous amino acid administration for assessment of anabolic response and metabolic phenotype.
Drug: Intravenous Amino Acids
Intravenous amino acid administration to assess anabolic response and protein kinetics in patients with chronic intestinal failure receiving home parenteral nutrition
Whole-Body Protein Kinetics (Protein Synthesis Rate) After Intravenous Amino Acid Infusion
Protein anabolic response will be assessed by whole-body protein kinetics using a stable isotope tracer methodology during intravenous amino acid administration. The outcome will be reported as the change in whole-body protein synthesis rate (µmol/kg/h) from baseline to post-infusion.
Time frame: Baseline (prior to amino acid infusion) and immediately after amino acid infusion (within 1 day)
Plan to share: No
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Studies of the drug tested here: Amino Acids
Institute of Oncology Ljubljana