An observational study in Catheter-related Bloodstream Infection and Intestinal Failure, sponsored by Jinling Hospital, China. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2025-09-15.
Sponsored by Jinling Hospital, China · Observational
This retrospective cohort study aims to identify risk factors for catheter-related bloodstream infections (CRBSIs) in hospitalized patients with intestinal failure (IF), including all subtypes (Types I-III). The study included 321 patients with 9,365 catheter-days. Multivariate logistic and Cox regression analyses were used to identify independent risk factors. Stratified analyses identified subtype-specific risks, and hospital stay length and health economic outcomes were assessed. The study highlights the need for subtype-tailored prevention strategies and closer metabolic and immune monitoring in hospitalized IF patients.
64 studies on the registry are indexed under Intestinal Failure; 17 are open to participants now.
This study's enrollment of 321 is above the median of 60 across 19 observational studies indexed under Intestinal Failure.
Browse Intestinal Failure studies →Jinling Hospital, China is the lead sponsor of 131 studies on the registry; 35 are open to participants now.
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This single-center retrospective study enrolled 321 patients with intestinal failure admitted between 2021 and 2024. All included patients met the ESPEN 2023 diagnostic criteria for intestinal failure, defined as reduced intestinal function below the minimum necessary for absorption of macronutrients and/or water-electrolytes, thus requiring intravenous supplementation (IVS) to maintain health and/or growth. Patients were excluded if they met any of the following criteria: Catheter indwelling duration \<48 hours; Implanted catheter before admission; Complex components in PN difficult to quantify; Positive blood cultures with unclear CRBSI diagnosis; Alternative infection sources identified.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with intestinal failure who developed catheter-related bloodstream infection
Patients with intestinal failure who never developed catheter-related bloodstream infection
incidence rate of catheter-related bloodstream infection
frequency of catheter-related bloodstream infections occurring every 1,000 days
Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.
Proportion of patients with high calorie-to-nitrogen ratio
The proportion of patients receiving a parenteral nutrition formula with a non-protein calorie-to-nitrogen ratio (C/N ratio) equal to or greater than 100 kilocalories per gram of nitrogen (≥100 kcal/g N).
Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.
Incidence of lymphocytopenia
The proportion of patients with lymphocytopenia at baseline.
Time frame: Baseline.
Proportion of patients with high parenteral nutrition energy supply
The proportion of patients whose average proportion of daily energy from PN to measured resting energy expenditure (PN/REE) exceeds 0.6 during the catheter indwelling period.
Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.
Incidence of neutropenia
The proportion of patients with neutropenia at baseline.
Time frame: Baseline
All-cause length of hospital stay
The total duration of hospitalization, measured in days, from admission to discharge.
Time frame: At the time of hospital discharge, assessed up to 24 months.
Total hospitalization costs
The total direct medical costs (in CNY) incurred during the hospitalization.
Time frame: At the time of hospital discharge, assessed up to 24 months.
Plan to share: No
No publications or documents are linked to this record.
Ran from Jan 2025 to primary completion in Jun 2025, 5 months.
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This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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