Hypovolemia clinical trials
The registry lists 122 studies for Hypovolemia across more than 10 countries. 14 are recruiting or about to start. 70 of them are mainly about Hypovolemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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· Enrollment: 300 → 450 participants
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Who runs them
Seoul National University Hospital (6) · Oslo University Hospital (5) · University Hospital, Caen (3) · Rigshospitalet, Denmark (3) · Karolinska Institutet (3) · University Hospital, Clermont-Ferrand (3) · Ottawa Hospital Research Institute (2) · Assiut University (2)
What is being tested here
Drugs under test in Hypovolemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 10, phase 3 first
- Dec 2026Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · Odense University Hospital
- Nov 2026A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients · Pharmazz, Inc.
- Nov 2026IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients · Assiut University
- Dec 2026Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy · Northwestern University
- Jan 2027Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia · Yale University
- Jan 2027Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU · Izmir Katip Celebi University
- Jan 2027Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness · Izmir Katip Celebi University
- Mar 2027Fontan Outcomes in Oligemia vs Plethora in Univentricular CHD · Sisca Natalia Siagian
- Mar 2027Validation of a Wearable Bioimpedance Sensor for Hydration Monitoring · Mode Sensors AS
- Oct 2027Inferior Vena Cava Versus Subclavian Vein Collapsibility for Predicting Fluid Responsiveness in Trauma Hemorrhagic Shock · Assiut University
Who these studies take
Of the 9 Hypovolemia studies recruiting now, 5 (56%) set no upper age limit and 4 (44%) stop at 75 or younger. 2 (22%) take children under 18. 1 (11%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (11%) | 1 (11%) |
| 18 | 7 (78%) | 6 (67%) |
| 30 | 8 (89%) | 7 (78%) |
| 40 | 8 (89%) | 7 (78%) |
| 50 | 7 (78%) | 6 (67%) |
| 65 | 6 (67%) | 6 (67%) |
| 75 | 5 (56%) | 5 (56%) |
| 85 | 5 (56%) | 5 (56%) |
Across all 122 studies, recruiting or not: 33% stop at 75 or younger and 27% at 65; 15% take children; 2% are for women only and 2% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypovolemia studies take
Of 25 observational studies under Hypovolemia, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 12 mo8–20 · 19 studies | — | — |
| Observational | 15 mo10–30 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICUNov 4, 2026NCT07304648
- Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid ResponsivenessNov 4, 2026NCT07304661
Studies
Recruiting first, then most recently updated. Showing 50 of 122. Browse all 122 → or search them.
- Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICURecruitingNCT073046481 country
- Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid ResponsivenessRecruitingNCT073046611 country
- A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock PatientsRecruitingNCT05956418Phase 41 country
- Inferior Vena Cava Versus Subclavian Vein Collapsibility for Predicting Fluid Responsiveness in Trauma Hemorrhagic ShockNot yet recruitingNCT07817966
- Validation of a Wearable Bioimpedance Sensor for Hydration MonitoringNot yet recruitingNCT076554011 country
- Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic MyomectomyRecruitingNCT07286188Phase 41 country
- Fontan Outcomes in Oligemia vs Plethora in Univentricular CHDRecruitingNCT075352031 country
- Renal and Hepatic Abnormal Doppler Patterns in TraumaRecruitingNCT074925111 country
- Evaluate Recombinant Human Serum Albumin From Oryza Sativa In Patients With Hypoalbuminemia and/or Hypovolemia Requiring Urgent TreatmentNot yet recruitingNCT074359221 country
- Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled HypovolemiaRecruitingNCT035922901 country
- IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock PatientsNot yet recruitingNCT072067321 country
- Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)RecruitingNCT062630751 country
- Early Initiated Vasopressor Therapy in the Emergency DepartmentRecruitingNCT05931601Phase 32 countries
- Goal-Directed Fluid Therapy in Patients Undergoing Lower Limb SurgeriesNot yet recruitingNCT06133257Not applicable
- A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)CompletedNCT06072430Phase 31 country
- Effectiveness of the Pressure Recording Analytical Method in Predicting Fluid Responsiveness in Pediatric Critical Care PatientsCompletedNCT041864161 country
- Acetated Ringer´s Solution in Experimental HypovolemiaCompletedNCT05705115Phase 41 country
- Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic EchocardiographyCompletedNCT05054452Not applicable1 country
- Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General AnaesthesiaCompletedNCT02193412Not applicable1 country
- Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing PatientsCompletedNCT064809421 country
- Effects of Different Fluid Transfusion Regimens On Glycocalyx In Patients Undergoing Thoracic Surgery.CompletedNCT07192523Not applicable1 country
- Effect of Preoperative Fluid Therapy on Post-induction HypotensionCompletedNCT06231472Not applicable1 country
- A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney InjuryActive, not recruitingNCT055383511 country
- Echocardiographic Assessment of Volume Variation Secondary to Preoperative FastingCompletedNCT012583611 country
- Gelatin in ICU and SepsisTerminatedNCT02715466Phase 45 countries
- Ultrasound Guided Fluid Loading Before Spinal AnesthesiaCompletedNCT07108881Phase 41 country
- Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Mechanically Ventilated Patients Under Spontaneous ModeCompletedNCT064954891 country
- Crystalloid FLUID Choices for Resuscitation of Hospitalized PatientsCompletedNCT04512950Phase 41 country
- Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEPCompletedNCT061230391 country
- RApid Fluid Volume EXpansion in Patients in Shock After the Initial Phase of Resuscitation.TerminatedNCT02645851Not applicable1 country
- Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care UnitCompletedNCT067292681 country
- Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department PatientsTerminatedNCT037364211 country
- Interest of the Pleth Variability Index in NeurosurgeryCompletedNCT06624891Not applicable1 country
- Reliability of Internal Jugular Ultrasound : an Observational Transversal Study Conducted Using Images Registered From Patients (AIJV-I)Active, not recruitingNCT065912341 country
- Detection of Hypovolemia in the Elderly Patient Undergoing SurgeryCompletedNCT062299381 country
- Spectral Analysis of Central Venous Pressure WaveformCompletedNCT047335471 country
- Safety Study of Kedbumin 25% Versus Normal Saline in the Treatment of Post-Surgical Hypovolemia in Pediatric PatientsTerminatedNCT01531803Phase 41 country
- VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock PatientsActive, not recruitingNCT04257136Phase 21 country
- Plasma-Lyte 148® versUs Saline StudyCompletedNCT02721654Phase 42 countries
- Bedside Resources to Gauge Intravascular Volume StatusCompletedNCT03915587Not applicable1 country
- Dynamic Parameters in Evaluation of Fluid ResponsivenessCompletedNCT042838511 country
- Photoplethysmography for Diagnose Incipient HypovolemiaCompletedNCT055126111 country
- Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help?Status unknownNCT055574611 country
- Perioperative Fluid Therapy Optimization in Spinal SurgeryCompletedNCT03644654Not applicable1 country
- Analysis of Passive Leg Raise Test on Blood Pressure in Critically Ill Patients.Status unknownNCT055547831 country
- Safety and Efficacy of a 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Trauma PatientsCompletedNCT03338218Phase 47 countries
- Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic HyponatremiaCompletedNCT047449871 country
- Supplemental Oxygen in HypovolemiaCompletedNCT05150418Phase 11 country
- Methoxyflurane and Fentanyl in LBNPCompletedNCT04641949Phase 41 country
- Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia InductionCompletedNCT045738421 country