An observational study in Hemodynamic, Fluid Responsiveness and Venous Congestion, sponsored by Bicetre Hospital. Recruiting at 3 sites in 2 countries. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2025-01-13.
Sponsored by Bicetre Hospital · Observational
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes. Venous congestion, a marker of impaired fluid clearance, is increasingly recognized as a significant contributor to poor prognosis. Previous studies have demonstrated the coexistence of fluid responsiveness and venous congestion in critically ill patients. Notably, these studies were limited by the absence of fluid challenge-the gold standard for assessing fluid responsiveness-leaving the dynamic relationship between fluid responsiveness and venous congestion incompletely understood. This study aims to investigate the interplay and temporal evolution of fluid responsiveness and venous congestion following a standardized fluid challenge in critically ill patients.
98 studies on the registry are indexed under Hyperemia; 44 are open to participants now.
This study's planned enrollment of 64 is below the median of 100 across 46 observational studies indexed under Hyperemia.
Browse Hyperemia studies →Bicetre Hospital is the lead sponsor of 25 studies on the registry; 6 are open to participants now.
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Critically ill patients with evidence of inadequate tissue perfusion, who are already monitored using a pulse wave contour analysis-derived estimation of cardiac output (either calibrated or uncalibrated)，and for whom clinicians have decided to administer volume expansion through intravenous crystalloid infusion.
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Exclusion Criteria:
Patients with an aumentation of cardiac index\>= 15% after a fluid challenge
Patients without an aumentation of cardiac index\>= 15% after a fluid challenge
The difference in venous congestion (VExUS) changes between fluid responders and non-responders following a fluid challenge.
Time frame: before and after 15-minute fluid challenge.
The differential evolution of venous congestion (VExUS) changes between fluid responders and non-responders 1 hour after a fluid challenge.
Time frame: 1 hour after fluid challenge
Plan to share: Undecided
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Bicetre Hospital