Hypercholesterolemia: all 1,267 studies

Page 2 of 13. Open to participants first (105), then studies with results posted, then the rest; newest registration first within each.

• PET Imaging of Inflammation and Lipid Lowering StudyRecruitingNCT04073797Not applicable
• Russian Familial Hypercholesterolemia RegistryRecruitingNCT02208869
• Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale CanadaRecruitingNCT02009345
• Study of Awareness and Detection of Familial HypercholesterolemiaRecruitingNCT01960244
• Causes and Natural History of DyslipidemiasRecruitingNCT00353782
• Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 AgonistsCompletedNCT06640972Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of Enlicitide (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018/CORALreef AddOn)CompletedNCT06450366Phase 3Results posted
• Examination of the Effects of Chromium Levels on Glucose Metabolism, Lipid Metabolism, Morbidity and Mortality Rates in Patients Followed in Intensive Care UnitCompletedNCT06334042Results posted
• Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying TherapiesCompletedNCT06005597Phase 3Results posted
• A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH)CompletedNCT05952869Phase 3Results posted
• A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef LipidsCompletedNCT05952856Phase 3Results posted
• Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Renal Impairment Study (MK-0616-020)CompletedNCT05934292Phase 1Results posted
• Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.CompletedNCT05888103Phase 3Results posted
• Efficacy and Safety of Inclisiran as Monotherapy in Patients With Primary Hypercholesterolemia Not Receiving Lipid-lowering Therapy.CompletedNCT05763875Phase 3Results posted
• A Clinical Study in Children With Heterozygous Familial Hypercholesterolemia (HeFH) Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing (CLEAR Path 1)CompletedNCT05694260Phase 2Results posted
• Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.CompletedNCT05425745Phase 3Results posted
• A Dose-Finding Study in Japanese Patients to Evaluate the Effect of Obicetrapib as an Adjunct to Stable Statin Therapy.CompletedNCT05421078Phase 2Results posted
• Study to Evaluate the Effect of Obicetrapib in Combination With Ezetimibe as an Adjunct to HIS TherapyCompletedNCT05266586Phase 2Results posted
• A Study of the Efficacy and Safety of Enclitide Chloride (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008)CompletedNCT05261126Phase 2Results posted
• Study of Efficacy, Safety, Tolerability and Quality of Life of Inclisiran (KJX839) vs Placebo, on Top of Ongoing Individually Optimized Lipid-lowering Therapy, in Participants With HypercholesterolemiaCompletedNCT05192941Phase 4Results posted
• Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying TherapiesCompletedNCT05142722Phase 3Results posted
• Technology-Assisted Cholesterol Trial in Consumers (TACTiC)CompletedNCT04964544Phase 3Results posted
• Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary SyndromeCompletedNCT04873934Phase 3Results posted
• Supplements, Placebo, or Rosuvastatin StudyCompletedNCT04846231Phase 2Results posted
• A Dose-finding Trial of ETC-1002(Bempedoic Acid) in Patients With HypercholesterolemiaCompletedNCT04784442Phase 2Results posted
• Randomized Study of Obicetrapib in Combination With EzetimibeCompletedNCT04770389Phase 2Results posted
• Randomized Study of Obicetrapib as an Adjunct to Statin TherapyCompletedNCT04753606Phase 2Results posted
• Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-CCompletedNCT04666298Phase 2Results posted
• Anti-inflammatory Effects of SimvastatinTerminatedNCT04638400Phase 4Results posted
• Lipid Management in Renal Transplant Recipients Using Evolocumab.CompletedNCT04608474Phase 4Results posted
• Online Trial Examining Validity and Reliability of the Shared Decision Making Process SurveyCompletedNCT04317690Results posted
• Online Trial Examining Validity of the Shared Decision Making Process Survey With Video VignettesCompletedNCT04317274Not applicableResults posted
• Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR EventsCompletedNCT04271280Results posted
• Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial HypercholesterolemiaCompletedNCT04233918Phase 3Results posted
• Phase 2a Study to Assess CIVI 007 in Patients on a Background of Statin TherapyCompletedNCT04164888Phase 2Results posted
• Evaluating the Efficacy of Pediatric Lipid Screening AlertsCompletedNCT04118348Not applicableResults posted
• A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03851705Phase 3Results posted
• Open-Label Extension to Evaluate the Longer Term Efficacy and Safety of LIB003CompletedNCT03847974Phase 2Results posted
• Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-CCompletedNCT03814187Phase 3Results posted
• Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)CompletedNCT03768427Phase 3Results posted
• Effect of a Treatment With a Nutraceutical Combination on Sub-optimal LDL Cholesterol LevelsCompletedNCT03739242Not applicableResults posted
• Long Term Safety Study of PRALUENTTerminatedNCT03694197Phase 4Results posted
• Dose-ranging Efficacy and Pharmacokinetics Study of Intravenous Atorvastatin in Hypercholesterolemic PatientsCompletedNCT03611010Phase 2Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT03510884Phase 3Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT03510715Phase 3Results posted
• Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Participants With Primary Hypercholesterolemia and Mixed DyslipidemiaTerminatedNCT03433755Phase 3Results posted
• Usability Study of the Commercial Auto-injector Device and the New Auto-injector Device (SYDNEY) in Patients With High or Very High CV Risk With Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying TherapyCompletedNCT03415178Phase 3Results posted
• Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03409744Phase 3Results posted
• Safety and Tolerability of Repatha® (Evolocumab) in Indian Participants With Homozygous Familial HypercholesterolemiaCompletedNCT03403374Phase 4Results posted
• Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein CholesterolCompletedNCT03400800Phase 3Results posted
• Efficacy and Safety of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03399786Phase 3Results posted
• Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein CholesterolCompletedNCT03399370Phase 3Results posted
• Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH)CompletedNCT03397121Phase 3Results posted
• A Multiple Ascending Dose Study of HTD1801 in Adults With HypercholesterolemiaCompletedNCT03381287Phase 1/2Results posted
• Impact of LDL-cholesterol Lowering on Platelet ActivationTerminatedNCT03331666Phase 4Results posted
• HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental DisabilitiesCompletedNCT03206164Not applicableResults posted
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor TherapyCompletedNCT03193047Phase 2Results posted
• Study of Evinacumab (REGN1500) in Participants With Persistent HypercholesterolemiaCompletedNCT03175367Phase 2Results posted
• Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial DiseaseCompletedNCT03161327Not applicableResults posted
• Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03156621Phase 3Results posted
• Dapagliflozin and Cholesterol Metabolism in Type 2 Diabetes (DM2)CompletedNCT03074630Phase 4Results posted
• Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)CompletedNCT03067441Phase 3Results posted
• An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High CholesterolCompletedNCT03060577Phase 2Results posted
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-CCompletedNCT03051100Phase 2Results posted
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)CompletedNCT03001076Phase 3Results posted
• Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular RiskCompletedNCT02991118Phase 3Results posted
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin IntolerantCompletedNCT02988115Phase 3Results posted
• Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With HypercholesterolemiaCompletedNCT02984982Phase 4Results posted
• A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT02963311Phase 2Results posted
• Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to PlaceboCompletedNCT02957682Phase 4Results posted
• Alirocumab in Patients With Acute Myocardial InfarctionCompletedNCT02938949Phase 4Results posted
• Feasibility and Acceptability of a Beverage Intervention for Hispanic AdultsCompletedNCT02911753Not applicableResults posted
• An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT02890992Phase 2Results posted
• A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)CompletedNCT02748057Phase 3Results posted
• A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)CompletedNCT02741245Phase 3Results posted
• Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed DyslipidemiaCompletedNCT02739984Phase 3Results posted
• Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)CompletedNCT02722408Phase 2Results posted
• Trial of Antroquinonol in Patients With Hypercholesterolemia and HyperlipidemiaCompletedNCT02719028Phase 2Results posted
• Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With HypercholesterolemiaCompletedNCT02715726Phase 3Results posted
• Open-Label Study To Evaluate MN-001 on HDL & Triglyceride in NASH & NAFLD SubjectsCompletedNCT02681055Phase 2Results posted
• Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)CompletedNCT02666664Phase 3Results posted
• A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)TerminatedNCT02651675Phase 1/2Results posted
• Effect On Serum Cholesterol Of Dairy Products With Addition Of Esterified PhytosterolsCompletedNCT02644109Phase 4Results posted
• Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the BloodTerminatedNCT02634606Phase 3Results posted
• Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4CompletedNCT02634580Phase 3Results posted
• A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity StatinsCompletedNCT02634151Phase 2Results posted
• Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)CompletedNCT02624869Phase 3Results posted
• Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)CompletedNCT02597127Phase 2Results posted
• Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study EnrollmentCompletedNCT02585895Phase 3Results posted
• Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)CompletedNCT02585778Phase 3Results posted
• Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of StatinCompletedNCT02584504Phase 3Results posted
• Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World SettingCompletedNCT02565615Results posted
• A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383)CompletedNCT02550288Phase 3Results posted
• Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)CompletedNCT02476006Phase 3Results posted
• A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384)CompletedNCT02460159Phase 3Results posted
• A Study to Evaluate the Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT02434497Phase 3Results posted
• Trial Assessing Efficacy, Safety and Tolerability of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition in Paediatric Subjects With Genetic Low-Density Lipoprotein (LDL) DisordersCompletedNCT02392559Phase 3Results posted
• Effect of an Atlantic Diet on Anthropometric Indices and Serum Lipid ProfileCompletedNCT02391701Not applicableResults posted
• Effect of Atorvastatin on Bone-vascular AxisCompletedNCT02342015Phase 4Results posted
• Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis TherapyCompletedNCT02326220Phase 3Results posted

← Hypercholesterolemia overview