AstraZeneca: Hypercholesterolemia trials

The registry lists 60 Hypercholesterolemia studies with AstraZeneca as lead sponsor. 3 are open to participants now and 7 have results posted.

Phase 1 5Phase 3 25Phase 4 5No phase 25(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin, and Placebo on LDL-C in LLT-naïve PatientsNot yet recruitingNCT07930507Phase 3
• A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.RecruitingNCT07619131Phase 3
• A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Rosuvastatin on LDL-C in Patients With HypercholesterolaemiaRecruitingNCT07619118Phase 3
• Technology-Assisted Cholesterol Trial in Consumers (TACTiC)CompletedNCT04964544Phase 3Results posted
• Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and TriglyceridesCompletedNCT00812955Phase 3Results posted
• Compare the Efficacy of Rosuvastatin to Atorvastatin in High Risk Patients With HypercholesterolemiaCompletedNCT00683618Phase 3Results posted
• 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With EzetimibeCompletedNCT00525824Phase 3Results posted
• A Multicenter Study Comparing the Safety and Efficacy of ABT-335 and Rosuvastatin Calcium Combination Therapy to Monotherapy in Subjects With DyslipidemiaCompletedNCT00463606Phase 3Results posted
• Study of Asian Patients With Hypercholesterolaemia in the UK - Rosuvastatin 5mg Versus Atorvastatin 10mgTerminatedNCT00427960Phase 4Results posted
• Rosuvastatin in the Long-term Treatment of Hypercholesterolaemic Subjects With Coronary Heart DiseaseCompletedNCT00329160Phase 4Results posted
• A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy AdultsCompletedNCT07513571Phase 1
• A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.CompletedNCT06742853Phase 1
• A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.CompletedNCT05787002Phase 1
• A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 in Healthy SubjectsCompletedNCT05384262Phase 1
• A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.CompletedNCT03593785Phase 1
• Centralised Pan-Algerian Survey on the Undertreatment of HypercholesterolemiaCompletedNCT01768403
• Observational Study to Understand Patients' and Physicians' Attitudes to Statins in TurkeYCompletedNCT01625884
• An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and LebanonCompletedNCT01614561
• Centralized Pan-Middle East Survey on the Undertreatment of HypercholesterolemiaCompletedNCT01604733
• Evaluation of Patients Treated With HMG-CoA Reductase Inhibitors to Reach Cholesterol Target ValuesCompletedNCT01483950
• Pattern of Statins Use in CataloniaCompletedNCT01477944
• Registry On Efficacy and Safety Of Rosuvastatin, and Atorvastatin and Simvastatin In HypercholesterolaemiaCompletedNCT01352897
• Non-interventional Study (NIS) to Assess Reaching of Cholesterol Target Values in Patients Treated With HMG-CoA Reductase InhibitorsCompletedNCT01257971
• Polish Survey on the Efficacy of the Hypercholesterolemia TreatmentCompletedNCT01243255
• An Epidemiological Study Aimed to Record Standard Daily Practice in Managing Patients With HypercholesterolemiaCompletedNCT01206231
• Efficiency of Rosuvastatin Versus the Fixed Combination of Ezetimibe/Simvastatin in OutpatientsCompletedNCT01164397
• Centralized Pan-Middle East Survey on the Under-treatment of Hypercholesterolemia, Sub-study for the Gulf StatesCompletedNCT01031277
• Centralized Pan-Middle East Survey on the Undertreatment of HypercholesterolemiaCompletedNCT01025388
• Evaluation of Crestor® (Rosuvastatin) in Daily PracticeCompletedNCT00837083
• Rosuvastatin Efficacy and Safety Evaluation in Hypercholesterolaemic PatientsCompletedNCT00695539
• C-Control: Efficacy and Safety of Therapy With Rosuvastatin in Statin-Naive and in Statin-Switched PatientsCompletedNCT00688454
• Centralized Pan-Asian Survey on the Under Treatment of HypercholesterolemiaCompletedNCT00687492
• Assessment of the Efficacy of Rosuvastatin in Patient Groups With a Dissimilar Risk Profile in an Observational Study (HEROS)CompletedNCT00660764
• STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose RangesCompletedNCT00654537Phase 3
• COMETS - Compare the Efficacy of Rosuvastatin With Atorvastatin and Placebo in the Treatment of Non-Diabetic, Non-Atheroscleric, Metabolic Syndrome SubjectsCompletedNCT00654485Phase 3
• Mercury II - Compare the Efficacy and Safety of Lipid Lowering Agents Atorvastatin and Simvastatin With Rosuvastatin in High Risk Subjects With Type IIa and IIb HypercholesterolemiaCompletedNCT00654407Phase 3
• Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic SubjectsCompletedNCT00654394Phase 3
• OLE Study to Evaluate Safety / Efficacy of ZD4522CompletedNCT00654303Phase 3
• Treatment of Hypercholesterolaemia in South Asian Subjects (IRIS)CompletedNCT00654225Phase 3
• Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)CompletedNCT00654173Phase 3
• Treatment of Hypercholesterolaemia in Hispanic Subjects (STARSHIP)CompletedNCT00653965Phase 3
• Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)CompletedNCT00653744Phase 3
• Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 WeeksCompletedNCT00653588Phase 3
• Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mgCompletedNCT00653445Phase 3
• Evaluation of the Efficacy of Rosuvastatin in Daily Practice in Untreated High Risk Patients (CHALLENGE)CompletedNCT00574782
• Pan-European Survey on the Under Treatment of HypercholesterolemiaCompletedNCT00542867
• Real-life EValuation Of High Dose RosUvastatin in High Risk Patients After TitraTIONCompletedNCT00526721
• InPractice Survey on the Treatment of HypercholesterolemiaCompletedNCT00523796
• ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL GoalsWithdrawnNCT00396240Phase 4
• Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET)CompletedNCT00396110
• Rosuvastatin ORBITAL GermanyCompletedNCT00379249Phase 3
• Observational to Investigate the Efficacy of CRESTOR 5mg in Reaching LDL-C Target Goals in Patients Who Are at High Risk for a Cardiovascular EventCompletedNCT00347217
• Korean Rosuvastatin Effectiveness Study in Nondiabetic Metabolic SyndromeCompletedNCT00335699Phase 4
• PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.CompletedNCT00329173Phase 3
• DISCOVERY Asia - Crestor in Type IIa and IIb HypercholesteremiaCompletedNCT00241488Phase 3
• Effect of an Internet Based Compliance Enhancement Tool in Subjects With HypercholesterolemiaWithdrawnNCT00240357Phase 4
• Study in High Risk Patients Switched From Higher Doses of Other Statins to Crestor on the Percentage of Patients Reaching the New LDL-C Target GoalCompletedNCT00240344
• The Effect of Rosuvastatin on Aortic Stiffness in Hemodialysis Patients in the AURORA StudyCompletedNCT00240279Phase 3
• Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin TherapyCompletedNCT00239330Phase 3
• A Study Measuring Effects on Intima Media Thickness: An Evaluation of Rosuvastatin 40 mg (METEOR)CompletedNCT00225589Phase 3