Histiocytoma, Malignant Fibrous clinical trials
The registry lists 91 studies for Histiocytoma, Malignant Fibrous across more than 10 countries. 15 are recruiting or about to start. 11 of them are mainly about Histiocytoma, Malignant Fibrous (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
European Organisation for Research and Treatment of Cancer - EORTC (15) · National Cancer Institute (NCI) (14) · Memorial Sloan Kettering Cancer Center (4) · M.D. Anderson Cancer Center (4) · Oslo University Hospital (2) · Brown University (2) · Eli Lilly and Company (2) · OHSU Knight Cancer Institute (2)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 2 programmes from 2 companies, 0 with this as their studies’ main aim; 0 with a live phase 3 study; 0 primary completions in the next 12 months.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
| Drug | Leading trial sponsor · US rights | Companies, last 5 years |
|---|---|---|
DoxorubicinRecent, limitedEvidence
| Hoffmann-La Roche10% of its industry studiesUS: off-patent, 14 generics marketed | 11 study |
IfosfamideRecent, limitedEvidence
| Eli Lilly and Company50% of its industry studiesUS: off-patent, 3 generics marketed | 11 study |
GemcitabineRecent, limitedEvidence
| Eli Lilly and Company30% of its industry studiesUS: off-patent, 11 generics marketed | 11 study |
1 more in limited or earlier use — sign in to see them, free.
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 2 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US rights and FDA-approved drug: from FDA’s records (Drugs@FDA via openFDA) — the holder of a marketed approval, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where FDA lists nothing: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Histiocytoma, Malignant Fibrous studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pembrolizumab | 4 | 1 | 5 |
| Doxorubicin | 1 | 5 | 11 |
| Liposomal doxorubicin | 1 | 0 | 3 |
| Cabozantinib | 1 | 0 | 2 |
| Toripalimab | 1 | 0 | 2 |
| DT-7012 | 1 | 0 | 1 |
| Peposertib | 1 | 0 | 1 |
| Lifileucel | 1 | 0 | 1 |
| Regorafenib | 1 | 0 | 1 |
| Multiple TAA-loaded Dendritic Cell Vaccine | 1 | 0 | 1 |
Drug classes tested here Immune checkpoint inhibitors 5 open · Tyrosine kinase inhibitors (TKIs) 2 open · Alkylating agents 8 · Angiogenesis inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas · Institut Bergonié
- Dec 2026Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery · National Cancer Institute (NCI)
- Jan 2027Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma · Jonsson Comprehensive Cancer Center
- Apr 2027A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg · Memorial Sloan Kettering Cancer Center
- Apr 2027LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas · M.D. Anderson Cancer Center
- May 2027Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma · National Cancer Institute (NCI)
- Oct 2027Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery · M.D. Anderson Cancer Center
Who these studies take
Of the 11 Histiocytoma, Malignant Fibrous studies recruiting now, 9 (82%) set no upper age limit and 2 (18%) stop at 75 or younger. 3 (27%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (100%) | 11 (100%) |
| 30 | 11 (100%) | 11 (100%) |
| 40 | 11 (100%) | 11 (100%) |
| 50 | 11 (100%) | 11 (100%) |
| 65 | 11 (100%) | 11 (100%) |
| 75 | 9 (82%) | 9 (82%) |
| 85 | 9 (82%) | 9 (82%) |
Across all 91 studies, recruiting or not: 14% stop at 75 or younger and 5% at 65; 36% take children; 1% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Histiocytoma, Malignant Fibrous studies take
Of 23 phase 2 interventional studies under Histiocytoma, Malignant Fibrous, half reached primary completion within 74 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 74 mo43–94 · 23 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 91. Browse all 91 → or search them.
- Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated SarcomasRecruitingNCT06422806Phase 33 countries
- Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced SarcomaRecruitingNCT05711615Phase 11 country
- A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue SarcomaRecruitingNCT07741877Phase 21 country
- Doxorubicin With or Without DT-7012 in Advanced Soft Tissue SarcomaNot yet recruitingNCT07802652Phase 21 country
- SBRT Combined With Reduced-Dose Anthracycline Chemotherapy and Toripalimab as Neoadjuvant Therapy for Localized High-Risk Undifferentiated Pleomorphic SarcomaNot yet recruitingNCT07817095Phase 21 country
- A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid TumorsRecruitingNCT06789172Phase 13 countries
- A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or LegRecruitingNCT04332874Phase 21 country
- Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone SarcomasRecruitingNCT04055220Not applicable1 country
- Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue SarcomaRecruitingNCT07169344Phase 21 country
- Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.RecruitingNCT07173972Phase 21 country
- Combination of Pembrolizumab and Cabozantinib in Patients With Advanced SarcomasRecruitingNCT05182164Phase 21 country
- MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue SarcomaRecruitingNCT06277154Phase 21 country
- Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue SarcomaNot yet recruitingNCT06526897Not applicable
- Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma PatientsRecruitingNCT05961761Phase 23 countries
- Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone SarcomasNot yet recruitingNCT05515068
- Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by SurgeryActive, not recruitingNCT02923778Phase 22 countries
- LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue SarcomasActive, not recruitingNCT03449108Phase 21 country
- Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue SarcomaActive, not recruitingNCT05836571Phase 22 countries
- Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before SurgeryActive, not recruitingNCT03307616Phase 21 country
- Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene AmplificationsTerminatedNCT05827614Phase 11 country
- Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryCompletedNCT02180867Phase 2/33 countries
- Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic SarcomaTerminatedNCT04123535Not applicable1 country
- Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue SarcomaActive, not recruitingNCT04420975Phase 11 country
- Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma PatientsCompletedNCT04008238Not applicable1 country
- CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With SarcomaCompletedNCT03425279Phase 1/23 countries
- A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue SarcomasCompletedNCT03899805Phase 21 country
- Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic SarcomasCompletedNCT04242238Phase 11 country
- A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue SarcomaCompletedNCT02451943Phase 325 countries
- Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma SubtypesCompletedNCT02815995Phase 21 country
- Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer StudyTerminatedNCT05017103Phase 21 country
- Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone SarcomasCompletedNCT03277924Phase 1/23 countries
- Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue SarcomaWithdrawnNCT06370871Phase 3
- A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3)CompletedNCT03752398Phase 11 country
- ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or MyxofibrosarcomaActive, not recruitingNCT04480502Phase 22 countries
- Itacitinib in Treating Patients With Refractory Metastatic/Advanced SarcomasTerminatedNCT03670069Phase 11 country
- Vaccine Therapy in Treating Patients With Metastatic CancerCompletedNCT00020267Phase 11 country
- Liposomal Doxorubicin in Treating Children With Refractory Solid TumorsCompletedNCT00019630Phase 11 country
- Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue SarcomaCompletedNCT02584309Phase 21 country
- Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by SurgeryCompletedNCT02500797Phase 21 country
- Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by SurgeryCompletedNCT03009201Phase 11 country
- A Study of Bevacizumab in Combination With Chemotherapy for Treatment of OsteosarcomaCompletedNCT00667342Phase 21 country
- Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue SarcomaCompletedNCT00053794Phase 21 country
- Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal SarcomaCompletedNCT01344018Not applicable13 countries
- PET CT as Predictor of Response in Preoperative Chemotherapy for Soft Tissue SarcomaCompletedNCT00346125Not applicable1 country
- Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic SarcomaTerminatedNCT02601209Phase 1/21 country
- Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue SarcomaCompletedNCT00346164Phase 35 countries
- Phase 2 Study of 9-ING-41 With Chemotherapy in SarcomaWithdrawnNCT05116800Phase 21 country
- Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue SarcomaCompletedNCT01532687Phase 21 country
- A Study of LY3435151 in Participants With Solid TumorsTerminatedNCT04099277Phase 12 countries
- A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced SarcomasWithdrawnNCT04906876Phase 21 country