Hepatoblastoma clinical trials
The registry lists 82 studies for Hepatoblastoma across more than 10 countries. 17 are recruiting or about to start. 22 of them are mainly about Hepatoblastoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Breast cancer · Recruiting: 2 came in, 3 changed
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· Enrollment: 300 → 450 participants
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Who runs them
National Cancer Institute (NCI) (17) · Children's Oncology Group (9) · Emory University (4) · Masonic Cancer Center, University of Minnesota (3) · Memorial Sloan Kettering Cancer Center (3) · Seattle Children's Hospital (3) · Baylor College of Medicine (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2)
What is being tested here
Drugs under test in Hepatoblastoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Melphalan | 1 | 0 | 4 |
| Sodium thiosulfate | 1 | 3 | 4 |
| Cyclophosphamide | 1 | 0 | 4 |
| Fludarabine | 1 | 0 | 2 |
| Lenvatinib | 1 | 1 | 2 |
| Codrituzumab | 1 | 0 | 1 |
| Tegavivint | 1 | 0 | 1 |
| Talazoparib | 1 | 0 | 1 |
| Temozolomide | 1 | 0 | 1 |
| Vorinostat | 1 | 0 | 1 |
Drug classes tested here Alkylating agents 2 open · Tyrosine kinase inhibitors (TKIs) 1 open · Immune checkpoint inhibitors 1 open · Antimetabolites 1 open · PARP inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Paediatric Hepatic International Tumour Trial · Phase 3 · University of Birmingham
- Mar 2027Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery · Phase 3 · Children's Oncology Group
- Mar 2027A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy · Phase 3 · Shanghai Children's Medical Center
- Dec 2026Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors · Valent Technologies, LLC
- Dec 2026Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma · St. Jude Children's Research Hospital
- Dec 2026Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies · New York Medical College
- Jan 2027Reduced Intensity Haploidentical BMT for High Risk Solid Tumors · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Mar 2027B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) · St. Jude Children's Research Hospital
- Apr 2027Pucotenlimab Combined With Lenvatinib and Chemotherapy in the Treatment of Advanced, Relapsed/Refractory Hepatoblastoma in Children · Sun Yat-sen University
- Jun 2027A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment · Memorial Sloan Kettering Cancer Center
Who these studies take
Of the 16 Hepatoblastoma studies recruiting now, 2 (13%) set no upper age limit and 13 (81%) stop at 75 or younger. 15 (94%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 15 (94%) | 15 (94%) |
| 18 | 16 (100%) | 16 (100%) |
| 30 | 7 (44%) | 7 (44%) |
| 40 | 4 (25%) | 4 (25%) |
| 50 | 4 (25%) | 4 (25%) |
| 65 | 3 (19%) | 3 (19%) |
| 75 | 3 (19%) | 3 (19%) |
| 85 | 3 (19%) | 3 (19%) |
Across all 82 studies, recruiting or not: 91% stop at 75 or younger and 89% at 65; 98% take children; 0% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hepatoblastoma studies take
Of 18 phase 2 interventional studies under Hepatoblastoma, half reached primary completion within 56 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 56 mo49–85 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 82. Browse all 82 → or search them.
- A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After TreatmentRecruitingNCT04928677Phase 11 country
- Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsRecruitingNCT04851119Phase 1/21 country
- Molecular Basis of Pediatric Liver CancerRecruitingNCT039598001 country
- ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular CarcinomaRecruitingNCT04634357Phase 1/21 country
- B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)RecruitingNCT04897321Phase 11 country
- Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing SarcomaRecruitingNCT04901702Phase 1/22 countries
- A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT StrategyRecruitingNCT04478292Phase 31 country
- Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS MalignanciesRecruitingNCT04308330Phase 11 country
- Relapsed and Refractory Hepatoblastoma: A Prospective Registry and Liver Tumor Research Consortium InitiativeRecruitingNCT055566421 country
- Reduced Intensity Haploidentical BMT for High Risk Solid TumorsRecruitingNCT01804634Phase 21 country
- Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T CellsRecruitingNCT07148050Phase 11 country
- A Prospective Multicenter Clinical Study of SCCG Protocol and ctDNA 5hmc in Predicting the Chemotherapy Sensitivity and Monitoring the Recurrence and Metastasis of Hepatoblastoma in Children and AdolescentsRecruitingNCT07300449Phase 21 country
- Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T CellsRecruitingNCT06198296Phase 11 country
- Pucotenlimab Combined With Lenvatinib and Chemotherapy in the Treatment of Advanced, Relapsed/Refractory Hepatoblastoma in ChildrenRecruitingNCT07188311Not applicable1 country
- A French Multicenter Observational Retrospective Study of Rare Primary Liver CancersRecruitingNCT065416521 country
- Combined Modality Therapy in Hepatoblastoma: South Egypt Cancer Institute ExperienceRecruitingNCT025577501 country
- A Compassionate Use Program to Provide Access to Sodium ThiosulfateAvailableNCT041328821 country
- Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03213652Phase 24 countries
- Sodium Thiosulfate Otoprotection During Salvage Cisplatin TherapySuspendedNCT05756660Early Phase 11 country
- Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment TrialActive, not recruitingNCT04284774Phase 22 countries
- Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03210714Phase 22 countries
- Agnostic Therapy in Rare Solid TumorsActive, not recruitingNCT06638931Phase 21 country
- Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment TrialActive, not recruitingNCT04320888Phase 23 countries
- EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT03618381Phase 11 country
- Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03698994Phase 22 countries
- Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After SurgeryActive, not recruitingNCT03533582Phase 36 countries
- Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare TumorsActive, not recruitingNCT02867592Phase 21 country
- Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large ModelsCompletedNCT068228421 country
- Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid TumorsActive, not recruitingNCT04337177Phase 11 country
- Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Active, not recruitingNCT03155620Phase 24 countries
- Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT04195555Phase 23 countries
- Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver CancerCompletedNCT00980460Phase 36 countries
- Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03213704Phase 22 countries
- Paediatric Hepatic International Tumour TrialActive, not recruitingNCT03017326Phase 314 countries
- B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT04483778Phase 11 country
- Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)CompletedNCT03213678Phase 22 countries
- Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)CompletedNCT03213665Phase 22 countries
- Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)CompletedNCT03526250Phase 22 countries
- A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With CancerActive, not recruitingNCT06521567Phase 1/26 countries
- 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young AdultsNo longer availableNCT050643061 country
- Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)CompletedNCT03220035Phase 22 countries
- Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid TumorsCompletedNCT05302921Phase 21 country
- Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)CompletedNCT03233204Phase 22 countries
- Nab-paclitaxel in Combination with Gemcitabine for Pediatric Relapsed and Refractory Solid TumorsCompletedNCT03507491Phase 11 country
- Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver TumorsTerminatedNCT043158831 country
- Psychosocial Situation of Children With Rare Solid Abdominal Tumors and Their FamiliesCompletedNCT052451231 country
- A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard TherapyCompletedNCT02085148Phase 14 countries
- Evaluation of Lung Metastases Based on Ultrashort Echo Time MRICompletedNCT057631731 country
- Diagnostic Efficacy and Prognostic Value of 18F-FDG PET/CT (MR) in Pediatric Solid BlastomaCompletedNCT061905741 country
- Auto Transplant for High Risk or Relapsed Solid or CNS TumorsCompletedNCT01505569Not applicable1 country