Esophageal Motility Disorders clinical trials
The registry lists 37 studies for Esophageal Motility Disorders across more than 10 countries. 11 are recruiting or about to start. 21 of them are mainly about Esophageal Motility Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 6 narrower conditions too, such as Gastroesophageal Reflux: 1,455 studies, 258 open.
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Who runs them
Assiut University (3) · Baylor College of Medicine (2) · Johns Hopkins University (2) · University of Massachusetts, Worcester (1) · Spital STS AG (1) · AdventHealth (1) · Nanfang Hospital, Southern Medical University (1) · The Cleveland Clinic (1)
What is being tested here
Drugs under test in Esophageal Motility Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Botulinum toxin type A | 2 | 1 | 2 |
| Prucalopride | 1 | 0 | 1 |
| Famotidine | 1 | 0 | 1 |
| Codeine | 0 | 0 | 1 |
| Azithromycin | 0 | 0 | 1 |
| Bethanechol | 0 | 0 | 1 |
| Anaprazole sodium | 0 | 0 | 1 |
| Anaprazole | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Nov 2026Dumping Syndrome and Esophageal Atresia · University Hospital, Lille
- May 2027Gastrointestinal Dysmotility on Aspiration Risk · Boston Children's Hospital
- Jul 2027Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions · Johns Hopkins University
- Jul 2027Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM) · Baylor College of Medicine
Who these studies take
Of the 8 Esophageal Motility Disorders studies recruiting now, 4 (50%) set no upper age limit and 4 (50%) stop at 75 or younger. 3 (38%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (25%) | 2 (25%) |
| 18 | 7 (88%) | 7 (88%) |
| 30 | 5 (63%) | 5 (63%) |
| 40 | 5 (63%) | 5 (63%) |
| 50 | 5 (63%) | 5 (63%) |
| 65 | 5 (63%) | 5 (63%) |
| 75 | 5 (63%) | 5 (63%) |
| 85 | 4 (50%) | 4 (50%) |
Across all 37 studies, recruiting or not: 43% stop at 75 or younger and 24% at 65; 16% take children; 0% are for women only and 0% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
- EndoFLIP-Guided Initial Management of Esophagogastric Junction Outflow ObstructionNov 10, 2026NCT07930143
Studies
Recruiting first, then most recently updated. Showing 37 of 37. search them.
- EndoFLIP-Guided Initial Management of Esophagogastric Junction Outflow ObstructionNot yet recruitingNCT07930143Not applicable1 country
- POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal AchalasiaRecruitingNCT07814027Not applicable1 country
- Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus PositionsRecruitingNCT07780981Not applicable1 country
- Gastrointestinal Dysmotility on Aspiration RiskRecruitingNCT05455359Phase 41 country
- Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)RecruitingNCT074968401 country
- High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal RefluxRecruitingNCT05132816Not applicable1 country
- Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. PyloromyotomyRecruitingNCT06721520Phase 2/31 country
- Dumping Syndrome and Esophageal AtresiaRecruitingNCT04522193Not applicable1 country
- Diagnostic Evaluation of Esophageal Motility Disorders Using the Chicago IV Protocol in EgyptNot yet recruitingNCT06878586
- Prevalence of IEM Among Upper GIT SymptomsNot yet recruitingNCT05913011
- Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After ARS in Patients With GERDRecruitingNCT053807911 country
- Monopolar and Bipolar Current RFA Knife in POEMCompletedNCT05272046Not applicable3 countries
- U-POEM vs CO2-POEMCompletedNCT06918730Not applicable1 country
- Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal ManometryCompletedNCT06329583Not applicable1 country
- Botulinum Toxin Injection in Hypercontractile EsophagusCompletedNCT01955174Phase 21 country
- Establishing a Correlation Between HRM and UGI MM StudiesTerminatedNCT063148931 country
- The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility DisordersCompletedNCT066290251 country
- A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux EsophagitisStatus unknownNCT05604261Phase 21 country
- Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University HospitalStatus unknownNCT05402462
- Esophageal Dysmotility - Prospective Study Evaluating Methods for Esophageal DilationTerminatedNCT03604523Not applicable1 country
- Pressure and Flow Study Before and After Treatments for EMD. The pFlow StudyStatus unknownNCT039040041 country
- Codeine on Pharyngeal and Esophageal MotilityCompletedNCT03784105Phase 41 country
- Correlation Between Clinical Signs and High-resolution Manometry Data in ChildrenStatus unknownNCT036624901 country
- NEQOL Survey Spanish Validation in a Hispanic Clinic Based PopulationCompletedNCT029594241 country
- Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal DisordersWithdrawnNCT02663206Not applicable1 country
- Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux DiseaseCompletedNCT03347903
- Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal AchalasiaStatus unknownNCT03012854Not applicable1 country
- Changes in Esophageal Motility and Swallowing Symptoms After Thyroid SurgeryStatus unknownNCT03100357
- The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy VolunteersCompletedNCT02736734Phase 41 country
- Effect of Azithromycin on Oesophageal HypomotilityCompletedNCT01448993Phase 21 country
- Topical Bethanechol for Improvement of Esophageal DysmotilityCompletedNCT01031043Phase 11 country
- Assessment of Esophageal Motility With Transnasal EndoscopyStatus unknownNCT016588651 country
- Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility DisordersStatus unknownNCT01524458Phase 1/21 country
- Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoringStatus unknownNCT014478231 country
- Endolumenal Partial Myotomy for Esophageal Motility DisordersStatus unknownNCT01302301Phase 21 country
- Esophageal Dysmotility and Dilatation After Laparoscopic Gastric BandingCompletedNCT01234428Not applicable1 country
- Comparison of Esophageal and Anorectal Manometry CathetersTerminatedNCT00204763Phase 41 country