A Phase 2 interventional study of Per oral endolumenal myotomy in Esophageal Motility Disorders, sponsored by The Oregon Clinic. Status unknown at 1 site in United States. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2011-02-28.
Sponsored by The Oregon Clinic · Phase 2, Interventional, and Treatment
Achalasia and esophageal spasm are primary esophageal motility disorders where the lower esophageal sphincter fails to relax in response to swallowing with no well understood underlying cause. Surgical myotomy represents an appropriate therapeutic option. The purpose of this study is to evaluate flexible endoscopic myotomy a novel therapeutic approach to overcome the need for invasive surgery.
In this study, the investigators propose the use of a recent endolumenal technique for partial myotomy in patients suffering from primary esophageal motility disorders.
Under general anesthesia patients will have upper endoscopy. Submucosal injection and mucosal incision is created for entry into the submucosal space. A submucosal tunnel is then created using a needle knife or blunt dissection as appropriate. Dissection will continue distally beyond the lower esophageal sphincter. The inner circular muscle fibers will then be divided to achieve an adequate myotomy length. The mucosal entry is then closed appropriately.
Results will be compared to historical data of conventional Heller myotomies.
43 studies on the registry are indexed under Esophageal Motility Disorders; 10 are open to participants now.
This study's planned enrollment of 20 is below the median of 28 across 24 interventional studies indexed under Esophageal Motility Disorders.
Browse Esophageal Motility Disorders studies →The Oregon Clinic is the lead sponsor of 11 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
flexible endoscopic submucosal esophageal partial myotomy
Esophageal Function Tests
upper endoscopy, barium swallow, esophageal manometry,ph Test
Time frame: 6 month
Quality of life score
quality of life questionaire
Time frame: 6 months
This study is status unknown, as verified in Nov 2010. You cannot join it, but the record below documents what was studied.
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Esophageal Motility Disorders→
The Oregon Clinic