Diphtheria clinical trials
The registry lists 267 studies for Diphtheria across more than 10 countries. 17 are recruiting or about to start. 142 of them are mainly about Diphtheria (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-26.
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· Enrollment: 300 → 450 participants
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Who runs them
GlaxoSmithKline (101) · Sanofi Pasteur, a Sanofi Company (62) · Sanofi (18) · Merck Sharp & Dohme LLC (7) · CanSino Biologics Inc. (7) · LG Chem (7) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Crucell Holland BV (3)
What is being tested here
Drugs under test in Diphtheria studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Nov 2026A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant Women · Phase 3 · GlaxoSmithKline
- Jan 2027Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy · Canadian Immunization Research Network
- May 2027Prospective Biological Study to Evaluate the Persistence of COVID-19 Vaccine and Other Vaccines'-Induced Immune Responses in Follicular Lymphoma Patients Undergoing Frontline Induction Immuno-chemotherapy and Anti-CD20 Maintenance · Fondazione Italiana Linfomi - ETS
- Aug 2027A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed · Institute of Medical Biology, Chinese Academy of Medical Sciences
Who these studies take
Of the 10 Diphtheria studies recruiting now, 2 (20%) set no upper age limit and 8 (80%) stop at 75 or younger. 6 (60%) take children under 18. 2 (20%) are for women only and 0 (0%) for men only; 9 (90%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (10%) | 1 (10%) |
| 18 | 3 (30%) | 1 (10%) |
| 30 | 5 (50%) | 3 (30%) |
| 40 | 5 (50%) | 3 (30%) |
| 50 | 4 (40%) | 3 (30%) |
| 65 | 2 (20%) | 1 (10%) |
| 75 | 2 (20%) | 1 (10%) |
| 85 | 2 (20%) | 1 (10%) |
Across all 267 studies, recruiting or not: 86% stop at 75 or younger and 85% at 65; 83% take children; 5% are for women only and <1% for men only; 96% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Diphtheria studies take
Of 46 phase 3 interventional studies under Diphtheria, half reached primary completion within 13 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 13 mo7–21 · 46 studies | 13 mo7–21 · 46 studies | — |
| Phase 4 | 22 mo8–30 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered2
- A Phase II Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents)Oct 26, 2026NCT07894055
- A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine AdsorbedOct 23, 2026NCT07891104
Studies
Recruiting first, then most recently updated. Showing 50 of 267. Browse all 267 → or search them.
- A Phase II Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents)RecruitingNCT07894055Phase 21 country
- A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine AdsorbedRecruitingNCT07891104Phase 1/21 country
- Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in PregnancyRecruitingNCT07097012Phase 41 country
- Study of BK1803 in Healthy InfantsNot yet recruitingNCT07793513Phase 31 country
- A Clinical Study on Immunogenicity Persistence of Adsorbed 5-component Acellular Pertussis, Diphtheria and Tetanus Combined VaccineNot yet recruitingNCT07744347
- Maternal Immunization With Tetanus Toxoid, Reduced Diphtheria Toxoid, Reduced-dose (2 µg) Recombinant Pertussis Vaccine (TdaP2gen) and Its Effect on the Immune Response in Thai Infants up to 15-18 Months OldNot yet recruitingNCT07621341Phase 41 country
- Enhancing Maternal Vaccine Knowledge and Uptake: The InTroDuce-Programme TrialRecruitingNCT06815250Not applicable1 country
- A Phase I Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents)Not yet recruitingNCT07492303Phase 1
- Phase I/II Clinical Trial of Diphtheria-Tetanus-Pertussis (Reduced Dose) VaccineNot yet recruitingNCT07418372Phase 1/21 country
- Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined VaccineRecruitingNCT07203755Phase 11 country
- Adsorption of Cell-free Diphtheria and Tetanus (Three-component) Combined With Vaccine Phase III Clinical TrialRecruitingNCT07112144Phase 31 country
- A Phase I/II Study to Evaluate the Safety and Immunogenicity of GC3111B in Healthy AdultsRecruitingNCT06997627Phase 1/21 country
- Study to Evaluate the Immunogenicity of LR20062 Compared to Control When Administered Intramuscularly in Healthy Infants At 2, 4, 6 Months of AgeNot yet recruitingNCT06618196Phase 2
- Assessing Interventions to Increase Tdap Acceptance for Non-birthing Partners in PregnancyRecruitingNCT06135636Phase 41 country
- Safety and Immunogenicity of DTaP-IPV/Hib Pentavalent Vaccine in Chinese 2-month-old InfantsRecruitingNCT06605755Not applicable1 country
- Phase I Clinical Trial of Diphtheria-Tetanus-acellular Pertussis Component Combined VaccineRecruitingNCT06184542Phase 11 country
- A Study to Evaluate Safety and Immunogenicity of APV006 in Healthy AdultsNot yet recruitingNCT05952596Phase 1
- A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Healthy Japanese Adolescents Aged 11 Years to <13 YearsCompletedNCT07596173Phase 31 country
- A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant WomenActive, not recruitingNCT07596199Phase 31 country
- Study to Evaluate the Immunogenicity and Safety of LBVD(Hexavalent Vaccine), Given to Healthy Infants at Primary SeriesCompletedNCT05457946Phase 2/31 country
- A Phase II/III Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, in Healthy Infants as Primary SeriesActive, not recruitingNCT06947499Phase 2/31 country
- A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component)CompletedNCT06708286Phase 2/31 country
- A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)CompletedNCT06056050Phase 11 country
- Safety and Immunogenicity Study of Tdap Vaccinations for Plasma DonorsCompletedNCT05662852Phase 21 country
- Prospective Biological Study to Evaluate the Persistence of COVID-19 Vaccine and Other Vaccines'-Induced Immune Responses in Follicular Lymphoma Patients Undergoing Frontline Induction Immuno-chemotherapy and Anti-CD20 MaintenanceActive, not recruitingNCT060709611 country
- Safety Monitoring of Boostagen® Vaccine in ThailandCompletedNCT074445021 country
- Confirmatory Study of BK1310 in Healthy InfantsCompletedNCT03891758Phase 31 country
- Study of BK1301 (DTaP Vaccine) as a Booster in AdolescentsCompletedNCT02118961Phase 31 country
- PFAS Exposure and Immune Response to Vaccination in AdultsCompletedNCT06588530Phase 41 country
- Study of DTwP-HepB-Hib-IPV (SHAN6™) Vaccine Administered Concomitantly With Routine Pediatric Vaccines to Healthy Infants and Toddlers in ThailandCompletedNCT04429295Phase 31 country
- A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, AdsorbedActive, not recruitingNCT05091619Phase 31 country
- Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South AfricaCompletedNCT04300192Phase 41 country
- Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and InfantsCompletedNCT04398706Phase 24 countries
- Inter-lot Consistency Clinical Trial of Adsorbed Cell-free DTP (Three-component) Combined VaccineActive, not recruitingNCT06857370Phase 31 country
- Cutaneous Diphtheria in France : Observational, Retrospective Study of Patient CharacteristicsCompletedNCT057982471 country
- Study on the Safety and Immunogenicity of Boostrix Vaccine in Pregnant Malian Women and Their InfantsCompletedNCT03589768Phase 22 countries
- Immune Response followingTdap Vaccine in PregnancyCompletedNCT040822991 country
- Sero-epidemiological Survey of England in 2019/2020 - COVID-19CompletedNCT040613821 country
- A Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed(DTcP)Active, not recruitingNCT05951725Phase 31 country
- Clinical Study on the Combined Administration of 15-Valent Pneumococcal Conjugate Vaccine and Diphtheria, Tetanus, Pertussis VaccineCompletedNCT06817187Phase 31 country
- A Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK)'s Infanrix Hexa Vaccine (DTPa-HBV-IPV/Hib) Versus MCM Vaccine BV's Vaxelis Vaccine (DTaP5-HBV-IPV-Hib) in Healthy Infants and ToddlersCompletedNCT04535037Phase 43 countries
- Impact of Boostrix™ Maternal Vaccination on Morbidity and Mortality of Pertussis Disease in Infants ≤6 Weeks of Age, in Bogota, Colombia.CompletedNCT025698791 country
- Immunogenicity and Safety of Vaccine Against Tetanus and Diphtheria.Active, not recruitingNCT05480462Phase 31 country
- Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruSCompletedNCT02458183Phase 32 countries
- Adapting Motivational Interviewing for Maternal Immunizations (MI4MI)CompletedNCT04302675Not applicable1 country
- Post-marketing Surveillance to Assess the Safety of Infanrix-IPV Vaccine Among Infants and Children in KoreaCompletedNCT015680601 country
- Phase I Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed .CompletedNCT04099303Phase 11 country
- Randomized Controlled Trial of the Impact of Mobile Phone Delivered Reminders and Travel Subsidies to Improve Childhood Immunization Coverage Rates and Timeliness in Western KenyaCompletedNCT01878435Not applicable1 country
- Post Marketing Surveillance for ADACEL™ in South KoreaCompletedNCT01137435Phase 41 country
- Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous DoseCompletedNCT01439165Phase 42 countries