Impact of Boostrix™ Maternal Vaccination on Morbidity and Mortality of Pertussis Disease in Infants ≤6 Weeks of Age, in Bogota, Colombia.

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• Whooping Cough 238
• Tetanus 198
• Diphtheria 265
• Aspergillosis 201
• Aspergillosis, Allergic Bronchopulmonary 45
• Tetany 60

Keywords

• Boostrix™
• Bagota
• maternal vaccination
• Pertussis
• Mortality
• Morbidity

Study population

Groups and cohorts

• Infants Group

  * All infants ≤12 months of age in Bogota, reported with pertussis disease in the national databases of Bogota, between January 2005 and December 2014. * All infants ≤12 months of age in Bogota, deceased between January 2005 and December 2014 due to pertussis disease (primary diagnosis), based on death certificate information. * All infants ≤12 months of age in Bogota, with ALRTI, between January 2005 and December 2014. * All infants ≤12 months who have received primary pertussis vaccination in Bogota, between January 2005 and December 2014.

  Other: Pertussis maternal immunization

• Pregnant women Group

  • Pregnant women will be included in the study to assess the vaccination coverage of Boostrix from March 2013 to December 2014

  Other: Pertussis maternal immunization

Interventions

• OtherPertussis maternal immunization

  Retrospective time trend analysis before and after pertussis maternal immunization in Bogota, Colombia.

Primary outcomes

1. Occurrence of reported cases of hospitalisations and deaths due to pertussis in infants ≤6 weeks of age, in post-vaccination period compared to pre-vaccination period of Boostrix vaccination

   Time frame: During the 9-year period (January 2005- December 2014)

Secondary outcomes

1. Occurrence of reported cases of hospitalisations and deaths due to pertussis in infants 7 weeks to ≤12 months of age, in post-vaccination period compared to pre-vaccination period of Boostrix vaccination

   Time frame: During the 9-year period (January 2005- December 2014)

2. Occurrence of ALRTI in infants ≤6 weeks of age and 7 weeks to ≤12 months of age, following the introduction of pertussis maternal immunisation in Bogota, Colombia

   Time frame: During the 9-year period (January 2005- December 2014)

3. Description of the total number of doses of Boostrix administered in pregnant women, after its introduction into the UMV program in Bogota

   Time frame: During the 9-year period (January 2005- December 2014)

4. Description of the total number of doses of primary pertussis vaccine administered to infants ≤12 months of age in Bogota

   Time frame: During the 9-year period (January 2005- December 2014)

Publications

• Carrasquilla G, Porras A, Martinez S, DeAntonio R, Devadiga R, Caceres DC, Juliao P. Incidence and mortality of pertussis disease in infants <12 months of age following introduction of pertussis maternal universal mass vaccination in Bogota, Colombia. Vaccine. 2020 Oct 27;38(46):7384-7392. doi: 10.1016/j.vaccine.2020.07.046. Epub 2020 Oct 2. PubMed 33012607 ↗

Individual participant data

Plan to share: No