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Diffuse Intrinsic Pontine Glioma clinical trials

The registry lists 119 studies for Diffuse Intrinsic Pontine Glioma across more than 10 countries. 39 are recruiting or about to start. 83 of them are mainly about Diffuse Intrinsic Pontine Glioma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed
41
Recruiting
29
Terminated
15
Active, not recruiting
12
Not yet recruiting
10
Status unknown
4

Phase

Phase 1
72
Phase 2
45
Early Phase 1
7
Phase 3
4

Where

United States
88
Canada
15
Australia
12
Germany
10
China
9
New Zealand
7

Who runs them

Nationwide Children's Hospital (10) · National Cancer Institute (NCI) (8) · St. Jude Children's Research Hospital (4) · Sabine Mueller, MD, PhD (4) · Children's Hospital Medical Center, Cincinnati (4) · University of Florida (3) · M.D. Anderson Cancer Center (3) · Children's Oncology Group (3)

What is being tested here

Drugs under test in Diffuse Intrinsic Pontine Glioma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Temozolomide217
Dordaviprone213
Nivolumab202
Everolimus105
Ribociclib104
Cetuximab102
C-X-C Chemokine Receptor Type 2101
Tovorafenib101
Gallium maltolate101
Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells101

Drug classes tested here Tyrosine kinase inhibitors (TKIs) 2 open · Alkylating agents 2 open · Immune checkpoint inhibitors 2 open · mTOR inhibitors 1 open · HDAC inhibitors 7

Coming up

2phase 3 studies under way
11studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 29 Diffuse Intrinsic Pontine Glioma studies recruiting now, 3 (10%) set no upper age limit and 26 (90%) stop at 75 or younger. 28 (97%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (7%) take healthy volunteers.

Recruiting studies that take each age, of 29
AgeWomenMen
1027 (93%)27 (93%)
1829 (100%)29 (100%)
3013 (45%)13 (45%)
404 (14%)4 (14%)
504 (14%)4 (14%)
654 (14%)4 (14%)
754 (14%)4 (14%)
853 (10%)3 (10%)

Across all 119 studies, recruiting or not: 90% stop at 75 or younger and 87% at 65; 99% take children; 0% are for women only and 0% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Diffuse Intrinsic Pontine Glioma studies take

Of 37 phase 1 interventional studies under Diffuse Intrinsic Pontine Glioma, half reached primary completion within 67 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 167 mo40–100 · 37 studies—67 mo40–92 · 35 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting1

Stopped1

Studies

Recruiting first, then most recently updated. Showing 50 of 119. Browse all 119 → or search them.