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CompletedNCT00283023Updated Oct 19, 2020

Oligodendrocyte Progenitor Cell Culture From Human Brain

A Phase 1 interventional study of Oligodendrocyte progenitor cell culture/craniotomy in Demyelinating Diseases, sponsored by Rajavithi Hospital. Completed at 1 site in Thailand. Open to participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-10-19.

Sponsored by Rajavithi Hospital · Phase 1, Interventional, and Basic science

Phase
Phase 1
Study type
Interventional
Enrollment
5
Allocation
Not applicable
Ages
20 Years to 65 Years
Sex
All
01

Study summary

Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.

Read the detailed description

Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

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Conditions studied

  • Demyelinating Diseases

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Keywords

  • All selective craniotomy
03

In context

Demyelinating Diseases

76 studies on the registry are indexed under Demyelinating Diseases; 27 are open to participants now.

This study's enrollment of 5 is below the median of 48 across 45 interventional studies indexed under Demyelinating Diseases.

Browse Demyelinating Diseases studies →

Lead sponsor

Rajavithi Hospital is the lead sponsor of 46 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Male or female 20-65 years of age
  • Informed consent
  • Has elective craniotomy surgery

Exclusion criteria

Exclusion Criteria:

  • HIV, hepatitis, and other central nervous system (CNS) infections
  • Dementia, Alzheimer disease, and neurodegenerative disease
05

Study design

Phase
Phase 1
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
5 participants (actual)

Study arms

  • Experimental
    A

    Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.

    Procedure: Oligodendrocyte progenitor cell culture/craniotomy

Interventions

  • ProcedureOligodendrocyte progenitor cell culture/craniotomy

    Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply

    Also known as: Rajavithi Oligodendrocyte progenitor cell culture protocol

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What researchers measure

Primary outcomes

  1. Number of oligodendrocyte progenitor cell differentiation

    Time frame: one month

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Study locations

1 site
  • Assistant Professor Subsai Kongsaengdao
    Bangkok, 10400, Thailand
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 19, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00283023
Lead sponsor
Rajavithi Hospital
First posted
Jan 27, 2006
Start date
Dec 2007
Primary completion
Dec 2010
Completion
Dec 2010
Last update
Oct 19, 2020

Study contacts

Subsai Kongsaengdao, M.D.
principal investigator · Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.

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