Cytokine Release Syndrome clinical trials
The registry lists 163 studies for Cytokine Release Syndrome across more than 10 countries. 31 are recruiting or about to start. 38 of them are mainly about Cytokine Release Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Ain Shams University (4) · Incyte Corporation (3) · Novartis Pharmaceuticals (3) · Alexandria University (2) · University of Colorado, Denver (2) · Masonic Cancer Center, University of Minnesota (2) · 101 Therapeutics (2) · Applied Science Private University (2)
What is being tested here
Drugs under test in Cytokine Release Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tocilizumab | 2 | 1 | 9 |
| Siltuximab | 2 | 0 | 4 |
| Etoposide | 2 | 1 | 3 |
| Teclistamab | 2 | 0 | 3 |
| Talquetamab | 2 | 0 | 2 |
| Ruxolitinib | 1 | 3 | 5 |
| Dexamethasone | 1 | 0 | 2 |
| Anti-CD20 Antibody-drug Conjugate MRG001 | 1 | 0 | 1 |
| Glofitamab | 1 | 0 | 1 |
| Linvoseltamab | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · JAK inhibitors 1 open · Corticosteroids 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Real-World Use of Tarlatamab in Chinese Patients With Small-Cell Lung Cancer · Ruijin Hospital
- Dec 2026Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma · Ontario Clinical Oncology Group (OCOG)
- Dec 2026Early Detection of Complications During Immunotherapy for Haematological Malignancy · Rigshospitalet, Denmark
- Jun 2027Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy · CytoAgents, Inc.
- Aug 2027Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma · SCRI Development Innovations, LLC
- Oct 2027Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS) · Regeneron Pharmaceuticals
- Oct 2027INfections in Patients Treated With CAR-T · IRCCS Azienda Ospedaliero-Universitaria di Bologna
Who these studies take
Of the 20 Cytokine Release Syndrome studies recruiting now, 15 (75%) set no upper age limit and 2 (10%) stop at 75 or younger. 2 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (10%) | 2 (10%) |
| 18 | 19 (95%) | 19 (95%) |
| 30 | 19 (95%) | 19 (95%) |
| 40 | 19 (95%) | 19 (95%) |
| 50 | 19 (95%) | 19 (95%) |
| 65 | 19 (95%) | 19 (95%) |
| 75 | 18 (90%) | 18 (90%) |
| 85 | 18 (90%) | 18 (90%) |
Across all 163 studies, recruiting or not: 19% stop at 75 or younger and 11% at 65; 14% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cytokine Release Syndrome studies take
Of 19 phase 2 interventional studies under Cytokine Release Syndrome, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 26 mo7–36 · 19 studies | — | — |
| Interventional, no phase | 10 mo5–25 · 26 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With TebentafuspWithdrawnNov 6, 2026NCT07803562
Newly registered4
- Wearable Core Body Temperature Monitoring for Early Detection of Cytokine Release Syndrome in Outpatients Receiving CAR T-Cell TherapyNov 2, 2026NCT07911540
- CLL-1/CD70 Dual-Target CAR-T Cell Therapy for Acute Myeloid LeukemiaOct 27, 2026NCT07897136
- Real-World Use of Tarlatamab in Chinese Patients With Small-Cell Lung CancerOct 21, 2026NCT07885332
- RPM Signals in Outpatient CAR T TherapyOct 20, 2026NCT07882732
Studies
Recruiting first, then most recently updated. Showing 50 of 163. Browse all 163 → or search them.
- Evaluate Optimization of CRS Profile for Glofit Monotherapy and Glofit+GemOx in R/R Aggressive B-NHLRecruitingNCT06806033Phase 27 countries
- Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE StudyRecruitingNCT063391771 country
- Wearable Core Body Temperature Monitoring for Early Detection of Cytokine Release Syndrome in Outpatients Receiving CAR T-Cell TherapyNot yet recruitingNCT07911540Not applicable1 country
- CLL-1/CD70 Dual-Target CAR-T Cell Therapy for Acute Myeloid LeukemiaNot yet recruitingNCT07897136Phase 11 country
- Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)RecruitingNCT07609940Phase 41 country
- RPM Signals in Outpatient CAR T TherapyNot yet recruitingNCT07882732
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Infliximab for Cytokine Release Syndrome Prophylaxis During Teclistamab or Talquetamab Therapy in Patients With Relapsed or Refractory MyelomaRecruitingNCT07657312Phase 21 country
- CLL-1-Targeted In Vivo CAR-T Cell Immunotherapy for Relapsed/Refractory Acute Myeloid LeukemiaNot yet recruitingNCT07841002Phase 11 country
- Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple MyelomaRecruitingNCT06421675Phase 21 country
- Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell TherapyRecruitingNCT05905328Phase 1/21 country
- INfections in Patients Treated With CAR-TNot yet recruitingNCT077135111 country
- Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse EventEnrolling by invitationNCT07499128Not applicable1 country
- Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to EpcoritamabRecruitingNCT06447376Phase 11 country
- Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)RecruitingNCT06684379Phase 1/21 country
- Early Detection of Complications During Immunotherapy for Haematological MalignancyRecruitingNCT06377059Not applicable1 country
- Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic LymphohistiocytosisNot yet recruitingNCT07497438Phase 31 country
- Outpatient Administration of Teclistamab or Talquetamab for Multiple MyelomaRecruitingNCT05972135Phase 21 country
- NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19)RecruitingNCT07502118Phase 2/31 country
- Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like SyndromeRecruitingNCT05306080Early Phase 11 country
- Jafron Cytokine Adsorber During Pediatric Open-Heart SurgeriesNot yet recruitingNCT07393087Not applicable1 country
- Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell ImmunotherapyRecruitingNCT07390071Not applicable1 country
- Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial)Not yet recruitingNCT07166549Phase 11 country
- Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I StudyRecruitingNCT07169487Phase 11 country
- A Phase II Study of Siltuximab for CRS/ICANs After CAR-T in Multiple MyelomaRecruitingNCT07106671Phase 21 country
- MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS PatientsNot yet recruitingNCT06308926Phase 2
- Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial SepsisRecruitingNCT064919661 country
- Immune Modulation by Exosomes in COVID-19RecruitingNCT051913811 country
- EFFECTS OF EXTRACORPOREAL CYTOKINE ELIMINATION ON HEMODYNAMIA AND MORTALITY IN CRITICAL PATIENTSEnrolling by invitationNCT059844071 country
- Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic LymphohistiocytosisRecruitingNCT05491304Phase 41 country
- Multiparametric Cardiac MRI in Patients Under CAR T-cell TherapyRecruitingNCT054141621 country
- Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With TebentafuspWithdrawnNCT07803562Phase 21 country
- Real-World Use of Tarlatamab in Chinese Patients With Small-Cell Lung CancerActive, not recruitingNCT078853321 country
- Pre-emptive Anakinra for Cytokine Event ReductionWithdrawnNCT06703216Phase 1/21 country
- Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell LymphomaActive, not recruitingNCT03696784Phase 11 country
- Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell TherapyCompletedNCT04975555Phase 21 country
- Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALLActive, not recruitingNCT03016377Phase 11 country
- INB03 for the Treatment of Pulmonary Complications From COVID-19TerminatedNCT04370236Phase 2/31 country
- Anakinra in Dengue With Hyperinflammation ( AnaDen )Active, not recruitingNCT05611710Phase 21 country
- A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated NeurotoxicityCompletedNCT04150913Phase 21 country
- Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 InfectionsCompletedNCT04751643Not applicable1 country
- Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).CompletedNCT062799101 country
- Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University HospitalCompletedNCT04979884Phase 31 country
- Siltuximab for Cytokine Release Syndrome Prophylaxis Prior to tx w/ Teclistamab in RRMMWithdrawnNCT06352866Phase 21 country
- CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19WithdrawnNCT04378244Phase 1/2
- Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)CompletedNCT04466098Phase 21 country
- Expanded Access for Use of bmMSC-Derived Extracellular Vesicles in Patients With COVID-19 Associated ARDSNo longer availableNCT04657458
- Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19CompletedNCT06676709Phase 1/21 country
- Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity SyndromeCompletedNCT05510596Not applicable1 country
- Fluoxetine to Reduce Intubation and Death After COVID19 InfectionCompletedNCT04377308Phase 41 country