Cystinuria clinical trials
The registry lists 21 studies for Cystinuria across 8 countries. 5 are recruiting or about to start. 14 of them are mainly about Cystinuria (how this is decided). Per ClinicalTrials.gov, last updated 2026-08-07.
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Who runs them
Mayo Clinic (5) · NYU Langone Health (5) · University of California, San Francisco (2) · Advicenne Pharma (2) · Devicare S.L. (1) · Revive Therapeutics, Ltd. (1) · Thomas Chi, MD (1) · Caleb Nelson (1)
What is being tested here
Drugs under test in Cystinuria studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dapagliflozin | 0 | 0 | 2 |
| Tiopronin | 0 | 0 | 2 |
| ADV7103 | 0 | 2 | 2 |
| Thioctic Acid | 0 | 0 | 1 |
| Tolvaptan | 0 | 0 | 1 |
| Bucillamine | 0 | 0 | 1 |
Who these studies take
Of the 5 Cystinuria studies recruiting now, 4 (80%) set no upper age limit and 0 (0%) stop at 75 or younger. 5 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (100%) | 5 (100%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 5 (100%) | 5 (100%) |
Across all 21 studies, recruiting or not: 14% stop at 75 or younger and 5% at 65; 48% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 21 of 21. search them.
- Prospective Research Rare Kidney Stones (ProRKS)RecruitingNCT027802974 countries
- Rare Kidney Stone Consortium BiobankRecruitingNCT020263881 country
- Rare Kidney Stone Consortium Patient RegistryRecruitingNCT005885622 countries
- Monogenic Kidney Stone - Genetic TestingRecruitingNCT033058351 country
- National Registry of Rare Kidney DiseasesRecruitingNCT060658521 country
- Lipoic Acid Supplement for Cystine StoneCompletedNCT02910531Phase 21 country
- Study Evaluating Patients With Cystinuria and Efficacy and Safety Exploratory Study in the Youngest ChildrenWithdrawnNCT04147871Phase 2/32 countries
- The Effect of Sodium-glucose Cotransporter (SGLT) 2 Inhibitors on Cystine Stone Formation: A Preliminary StudyCompletedNCT04818034Phase 21 country
- Long Term Clinical Efficacy of Sodium-glucose Cotransporter-2 (SGLT-2) Inhibitor in CystinuricsWithdrawnNCT05058859Phase 21 country
- Randall's Plaque Study: Pathogenesis and Relationship to NephrolithiasisActive, not recruitingNCT00169806Not applicable1 country
- Study Evaluating Patients With CystinuriaWithdrawnNCT04137978Phase 2/32 countries
- Registry of Thiola EC TherapyCompletedNCT050485631 country
- Health-related Quality of Life in Rare Kidney StoneCompletedNCT021243952 countries
- Effect of Urine Alkalinazation on Urinary Inflammatory Markers in Patients With CystinuriaCompletedNCT038361441 country
- Effect of Increasing Doses of Tiopronin on Cystine Capacity in Patients With CystinuriaCompletedNCT03663855Phase 21 country
- Effect of Increasing Doses of Cystine Binding Thiol Drugs on Cystine Capacity in Patients With CystinuriaCompletedNCT02125721Phase 41 country
- TCUPS- Tolvaptan Use in Cystinuria and Urolithiasis: A Pilot StudyCompletedNCT02538016Not applicable1 country
- Cystine Capacity Clinical Study (CysCap)CompletedNCT021201051 country
- This Study Evaluates the Superiority of Daily Self-pH Monitorization of Lit-control®pH Meter Compared to the Monitorization of Reactive Strips (Standard of Care).Status unknownNCT03539926Not applicable1 country
- Bucillamine Phase 2 Trial in Patients With CystinuriaStatus unknownNCT02942420Phase 21 country
- Use of an Herbal Preparation to Prevent and Dissolve Kidney StonesCompletedNCT00381849Phase 1/21 country