Cryptococcosis clinical trials
The registry lists 40 studies for Cryptococcosis across more than 10 countries. 4 are recruiting or about to start. 7 of them are mainly about Cryptococcosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Meningitis, Cryptococcal too: 73 studies, 9 open.
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Who runs them
Pfizer (12) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · University of Minnesota (3) · Merck Sharp & Dohme LLC (3) · Asahi Kasei Pharma Corporation (1) · National Cancer Institute (NCI) (1) · Oxford University Clinical Research Unit, Vietnam (1) · Singh, Ranjan Kumar, M.D. (1)
What is being tested here
Drugs under test in Cryptococcosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fluconazole | 0 | 1 | 14 |
| Amphotericin B | 0 | 1 | 8 |
| Posaconazole | 0 | 2 | 3 |
| Flucytosine | 0 | 0 | 2 |
| Itraconazole | 0 | 0 | 1 |
| Dexamethasone | 0 | 0 | 1 |
| Isavuconazole | 0 | 1 | 1 |
| Efavirenz | 0 | 0 | 1 |
| Nucleosides | 0 | 0 | 1 |
| Tamoxifen | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Jun 2027Cryptococcosis Associated With Bruton Tyrosine Kinase Inhibitors · Assistance Publique - Hôpitaux de Paris
Who these studies take
Of the 2 Cryptococcosis studies recruiting now, 1 (50%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (50%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (50%) | 1 (50%) |
| 18 | 2 (100%) | 2 (100%) |
| 30 | 2 (100%) | 2 (100%) |
| 40 | 2 (100%) | 2 (100%) |
| 50 | 2 (100%) | 2 (100%) |
| 65 | 2 (100%) | 2 (100%) |
| 75 | 2 (100%) | 2 (100%) |
| 85 | 2 (100%) | 2 (100%) |
Across all 40 studies, recruiting or not: 13% stop at 75 or younger and 8% at 65; 50% take children; 0% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Cryptococcosis Associated With Bruton Tyrosine Kinase InhibitorsOct 19, 2026NCT07881055
Studies
Recruiting first, then most recently updated. Showing 40 of 40. search them.
- Fungal Infection SusceptibilityRecruitingNCT000013521 country
- Cryptococcosis Associated With Bruton Tyrosine Kinase InhibitorsNot yet recruitingNCT078810551 country
- Digital Rewards and Retention in a M-health AppNot yet recruitingNCT06883773Not applicable1 country
- Vicente Ferrer HIV Cohort StudyRecruitingNCT024545691 country
- Prospective Observational Study on the Incidence of Opportunistic Fungal InfectionsCompletedNCT057071561 country
- Inpatient Package to Reduce HIV and AIDS-related Death in ZambiaCompletedNCT04033718Not applicable1 country
- Comprehensive Diagnosis and Treatment Strategy for Opportunistic Fungal Infections in AIDS PatientsStatus unknownNCT051530051 country
- A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal MeningitisCompletedNCT00000639Not applicable1 country
- Dexamethasone in Cryptococcal MeningitisCompletedNCT00000776Phase 22 countries
- Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep MycosisCompletedNCT03471988Phase 31 country
- Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid ComplexWithdrawnNCT01656382Phase 41 country
- Derivation and Validation of a Scoring System to Distinguish Cryptococcosis and Adenocarcinoma in Pulmonary NodulesStatus unknownNCT045548751 country
- Cryptococcal Antigen Screening Plus SertralineTerminatedNCT03002012Phase 31 country
- Cryptococcal Optimal ART Timing TrialCompletedNCT01075152Phase 42 countries
- Operational Research for Cryptococcal Antigen ScreeningCompletedNCT01535469Phase 41 country
- Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART CentreCompletedNCT039930931 country
- Treatment With Tamoxifen in Cryptococcal MeningitisCompletedNCT03112031Phase 21 country
- Vietnam Cryptococcal Retention in Care Study - Version 2.1Status unknownNCT032674071 country
- Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans InfectionCompletedNCT000017011 country
- Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)CompletedNCT00034658Phase 3
- Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)CompletedNCT00034632Phase 3
- PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)CompletedNCT00034671Phase 2
- Clinical Trial of Pulmonary Cryptococcosis in ChinaStatus unknownNCT02503449
- A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal InfectionCompletedNCT00784368Phase 31 country
- Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary MycosisStatus unknownNCT01125644Phase 31 country
- A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal InfectionsCompletedNCT00647907Phase 41 country
- Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDSCompletedNCT00001017Phase 31 country
- Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitisCompletedNCT00000708Not applicable1 country
- Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisCompletedNCT00002040Not applicable1 country
- Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitisCompletedNCT00002075Not applicable1 country
- SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance TherapyCompletedNCT00000677Phase 11 country
- An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisCompletedNCT00002077Not applicable1 country
- A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal MeningitisCompletedNCT00002305Not applicable2 countries
- A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin BCompletedNCT00002306Not applicable1 country
- A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.CompletedNCT00002113Not applicable1 country
- Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency SyndromeCompletedNCT00002019Not applicable1 country
- A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal MeningitisCompletedNCT00002068Not applicable2 countries
- A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDSCompletedNCT00002294Not applicable1 country
- Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency SyndromeCompletedNCT00002074Not applicable2 countries
- Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal MeningitisCompletedNCT00002076Not applicable1 country